Raymond B Penn
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Raymond B Penn has a total of 1 co-authors. Here are the top co-authors by number of shared publications:
- Charlotte K Billington
Department of Medicine, Division of Critical Care, Pulmonary, Allergic & Immunologic Diseases, Kimmel Cancer Center, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA
1 shared publication
Latest Publications
- Open Access
- 14 March 2003
- Published by Springer Nature in Respiratory Research
- Vol. 4 (1) , 1-23
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.
- 14 March 2003
- Published by Springer Nature in Respiratory Research
- Vol. 4 (1) , 1-23
Open AccessSignaling and regulation of G protein-coupled receptors in airway smooth muscle
Signaling through G protein-coupled receptors (GPCRs) mediates numerous airway smooth muscle (ASM) functions including contraction, growth, and "synthetic" functions that orchestrate airway inflammation and promote remodeling of airway architecture. In this review we provide a comprehensive overview of the GPCRs that have been identified in ASM cells, and discuss the extent to which signaling via these GPCRs has been characterized and linked to distinct ASM functions. In addition, we examine the role of GPCR signaling and its regulation in asthma and asthma treatment, and suggest an integrative model whereby an imbalance of GPCR-derived signals in ASM cells contributes to the asthmatic state.