Nermin Karaosmanoglu

Amaç: Bu çalışmada gebe kadınların kozmetik/kozmesötik ürün kullanım alışkanlıklarının, ürün içeriklerine ilişkin farkındalıklarının ve kozmetik/kozmesötik okuryazarlık düzeylerinin belirlenmesi amaçlandı.Gereç ve Yöntemler: Prospektif, tanımlayıcı ve kesitsel olarak yürütülen bu tek merkezli çalışmaya, dermatoloji polikliniğine başvuran ve gebeliği klinik olarak doğrulanmış 50 gönüllü kadın dahil edildi. Veriler, araştırmacılar tarafından geliştirilen yapılandırılmış anketle yüz yüze toplandı. Kozmetik/kozmesötik okuryazarlık, 10 maddeden oluşan Kozmetik/Kozmesötik Okuryazarlık Puanlama Sistemi (KOPS; 0–10 puan) ile değerlendirildi. İstatistiksel analizlerde Mann-Whitney U, Kruskal-Wallis ve Spearman korelasyon testleri kullanıldı; p

Objective: Pruritus is a common and challenging complaint for both patients and clinicians. The main aim was to compare short-term clinical outcomes of acupuncture and phototherapy in patients with chronic generalized pruritus in a real-world setting. Methods: The study included a total of 90 patients, 50 of whom were treated with acupuncture and 40 with phototherapy. Forty patients in the phototherapy group underwent narrowband UVB therapy for 1 month, and 50 patients in the acupuncture group received treatment for 1 month. The severity of pruritus was evaluated with the Investigator's Global Assessment (IGA) and Visual Analog Scale (VAS) at the beginning and first month. Results: The acupuncture group included 50 patients, 39 (78%) females and 11 (22%) males, with a mean age of 56.64 ± 14.83 years. The phototherapy group included 40 patients, 25 (62.5%) females and 15 (37.5%) males, with a mean age of 54.93 ± 14.90 years. At baseline, there was no statistically significant difference in VAS scores of pruritus between the phototherapy and acupuncture groups ( p = 0.353); however, at the end of the first month of treatment, the VAS scores were significantly lower in the acupuncture group compared to those in the phototherapy group ( p = 0.008). According to the IGA, the phototherapy group had higher scores than those in the acupuncture group both at baseline and at the end of the first month of treatment ( p = 0.002 and p < 0.001, respectively). Conclusions: Our study demonstrated that acupuncture may represent a potential alternative option in selected patients, particularly when phototherapy is not feasible or tolerated. Registration number: “NCT07451353” on 4 March 2026

AIMThis study aimed to retrospectively compare systemic inflammatory indices and hematologic parameters in patients with severe acne vulgaris (AV) and healthy individuals.MATERIAL AND METHODA total of 790 participants were included, consisting of 395 patients with severe AV and 395 healthy controls. Medical records were analyzed retrospectively. Inflammatory markers such as neutrophil, lymphocyte, monocyte, platelet counts, mean platelet volume (MPV), ferritin, mean corpuscular volume (MCV), red cell distribution width (RDW), Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), Aggregate Index of Systemic Inflammation (AISI) and MCV/RDW ratio were recorded and analyzed.RESULTSThe mean age of the AV group was significantly lower, and the proportion of females was lower compared to the control group (p

Background/Aim: Dermatological consultations from paediatric emergency departments are common but often underreported. Understanding the profile and outcomes of these consultations is crucial for improving diagnostic accuracy and patient management. The aim was to retrospectively analyse paediatric patients referred from the paediatric emergency department to the dermatology clinic in a tertiary care hospital over a 5‐year period, focusing on demographic characteristics, preliminary and final diagnoses, diagnostic concordance and treatment modalities. Methods: This retrospective observational study included paediatric patients (aged 0–18 years) consulted at the dermatology clinic from the paediatric emergency department of a tertiary care centre. Data collected included demographics, triage codes, consultation response times, diagnoses, examination findings and treatments. Results: A total of 486 patients were included, with a mean age of 95.3 ± 66.6 months. The gender distribution was 48.1% ( n = 234) female and 51.9% ( n = 252) male. The most frequent final diagnoses were scabies 14% ( n = 68), insect bites 7.8% ( n = 38) and urticaria–angioedema 7% ( n = 34). Diagnostic concordance between paediatricians and dermatologists was 64.23% ( n = 88 of 137 with preliminary diagnoses). Topical antibiotics 40.3% ( n = 196), systemic antihistamines 27.2% ( n = 132) and topical steroids 24.7% ( n = 120) were the most commonly prescribed treatments. Hospitalisation was required for 1.9% ( n = 9) of patients, and 4.3% ( n = 21) underwent biopsy. Conclusion: The majority of dermatology consultations from the paediatric emergency department were for non‐emergent conditions. Strengthening dermatology education in paediatric training programmes and establishing specialised paediatric dermatology outpatient clinics may improve diagnostic accuracy and patient care.

Aim: The aim of this study is to analyze the clinical and demographic characteristics, histopathological findings, and treatment responses of patients with pityriasis lichenoides. Additionally, the study aims to investigate the differences between pediatric and adult patients. Material and Method: The data of 47 patients with pityriasis lichenoides, followed up at the Dermatology Clinic of Ankara Training and Research Hospital between 01.08.2004 and 01.08.2024, were retrospectively analysed. The patients were classified as pityriasis lichenoides chronica and pityriasis lichenoides et varioliformis acuta. Clinical, demographic, and histopathological characteristics, as well as treatment responses, were evaluated. The patients were divided into pediatric (18 years) groups for comparison. In statistical analyses, a p-value of

Background: Pityriasis rubra pilaris (PRP) is a rare papulosquamous disease with a characteristic clinical appearance, including follicular salmon-coloured papules, which can sometimes progress into erythroderma. Both clinical and histopathological findings are important in diagnosing the disease and should be evaluated together. Objectives: There are no guidelines for diagnosis and treatment of the disease. The aim of the present study was to contribute to the clinical diagnosis and treatment approach of this rare disease, which could serve as a clinical guide for dermatologists. Methods: A total of 70 patients diagnosed with PRP in the last 20 years were included in this retrospective study. Clinical, demographic, and histopathologic profiles; and treatment strategies were analysed. Patients were divided into two groups with ‘definite’ or ‘probable’ diagnoses; those diagnosed to have PRP based on both clinical and histopathological findings were classified as having a ‘definite’ diagnosis; and those with histopathologically non-specific features but clinical findings compatible with PRP were classified as having a ‘probable’ diagnosis. Results: Forty (57.1%) patients were females and 30 (42.9%) were males. Their age ranged from 8 to 79 years (mean age 39.57±18.80 years). The median duration of the disease (before patients received the diagnosis) was 7 months (IQR=24). According to biopsy reports, the most common epidermal changes were hyperkeratosis (78.6%) and focal parakeratosis (75.7%), while the ‘checkerboard pattern,’ which is considered specific for the disease, was detected in only 16 (22.9%) cases. Only 8 biopsy samples (11.4%) had an eosinophilic infiltrate. While 47 (67.1%) patients were classified under ‘definite diagnosis and 23 (32.9%) were classified under ‘probable diagnosis.’ The disease duration was longer in patients with definite diagnosis than in patients with probable diagnosis (p=0.045). A total of 33 (47.14%) patients needed systemic therapy in addition to topical treatment. While 4 of these 33 patients were classified as Type 3, the remaining patients were classified as Type 1, classical adult type. Only three Type 1 (classical adult PRP) patients had erythroderma. Oral retinoids, especially acitretin, were the most preferred and effective treatment. Five patients showed improvement with methotrexate and two needed biological agents. Limitation: The present study is retrospective and includes a relatively limited number of patients. Conclusion: PRP is still a rare, difficult-to-manage disease. More studies are required to standardise and improve the diagnosis and treatment approaches for the disease.

Background: Isotretinoin is frequently used for treating severe, treatment-resistant, and scarring acne. A wide range of musculoskeletal side effects are reported due to isotretinoin, and one of them is enthesopathy. Objectives: In this study, we used ultrasound to evaluate tendon thickness and the presence of enthesophytes, erosions, calcifications, and bursitis. Overall, the main objective was to determine the effects of isotretinoin on enthesopathy. Methods: The study included 30 patients diagnosed with acne vulgaris (AV) and on isotretinoin treatment for ≥3 months. Thirty patients with AV without treatment or on topical treatments were included as the control group. In both groups, 5 areas in the lower limb were examined bilaterally for tendon thickness, erosion, calcifications, enthesophytes, and bursitis and compared among themselves. Moreover, the Glasgow Ultrasonographic Enthesitis Scoring System (GUESS) scores were also calculated and compared between the 2 groups. Results: The quadriceps tendon, distal patellar ligament, and right Achilles tendon thicknesses were statistically higher in the isotretinoin group than in the control group ( P = .02, P = .03, P = .04). The GUESS score was also statistically higher in the isotretinoin group ( P = .02). Conclusion: This study showed that isotretinoin has certain effects on tendon thickness. Clinicians should be alert that patients under isotretinoin treatment may develop enthesopathy even with no clinical signs.

Aim: The loss of smell is a common disease and can affect a patient’s quality of life. Olfactory disturbance leads to problems such as safety and eating. Acne vulgaris is a prevalent disease in the daily clinical practice of a dermatologist. Doxycycline and isotretinoin are the most preferred systemic drugs for severe acne. This study aimed to investigate the possible effects on olfactory function in patients with acne vulgaris receiving isotretinoin and doxycycline therapy by using the Brief Smell Identification Test. Material and Method: A total of 60 patients with acne vulgaris were included in the study. The patients were divided into two groups, each consisting of 30 patients. One group received oral doxycycline, while the other received oral isotretinoin. The olfactory function of each patient in both groups was assessed at the beginning and third month of treatment by using the Brief Smell Identification Test. Results: There was no statistically significant difference between the total scores of the Brief Smell Identification Test at 0. and 3. months in both the isotretinoin group and the doxycycline group. Conclusion: The results of the present study showed that both drugs are safe and have no undesirable effect on olfactory function. However, the certain effects of both drugs on olfactory functions still remain unknown. New studies are needed to shed light on this issue.

ÖZET Amaç: Bu çalışmanın amacı, erken evre Mikozis fungoides (MF) nedeniyle darband ultraviyole B (dbUVB) fototerapisi alan hastaların demografik özellikleri, hastalık yaygınlıkları, histopatolojik bulguları, fototerapi tedavi verileri ve yanıtlarının incelenmesidir. Gereç ve yöntem: Bu çalışmaya Şubat 2020 ile Şubat 2024 yılları arasında üçüncü basamak bir sağlık kuruluşunun fototerapi ünitesinde, klinik ve histopatolojik olarak MF tanısı doğrulanmış ve en az 12 hafta dbUVB monoterapisi alan hastalar kabul edildi. Çalışma için değerlendirme değişkenleri; yaş, cinsiyet, kaşıntı varlığı, daha önceki tedaviler, tanı alma süresi, vücut tutulum alanları, histopatolojik bulgular, fototerapi toplam dozu, fototerapi seans sayısı, fototerapi yanıtı, fototerapi yan etkileri olarak seçilmiştir. Değişkenler istatistiksel olarak analiz edilmişti. Bulgular: Çalışmaya 50 hastanın verileri dahil edildi. Hastaların yaş ortalaması 50,1±17,8’di Hastaların %50’si (n=25) erkekti, %50’si (n=25) kadındı. Hastaların ortalama tanı alma süreleri 75,37±9,05 aydı. Kaşıntı semptomu hastaların %30’unda (n=15) bildirilmişti. Hastaların %58’i (n=29) tedaviden tam yanıt aldı. Hastaların ortalama tedavi süreleri 14,2±7,2 aydı. Hastalar median 121 (36-324) seans dbUVB tedavisi almıştı. Evre 1A olan hastaların %65,6’sı (n=21), Evre 1B olan hastaların %44,4’ü (n=8) tedaviden fayda görmüştü. Hastaların %42’sinde (n=21) hafif eritem ve pruritus yan etkisi görülmüştü. Sonuç: DbUVB fototerapisi erken evre MF için efektif ve yan etki profili güvenilir bir tedavi yöntemidir. Anahtar kelimeler: kutanöz, lenfoma, tedavi

In this study, it was aimed to describe isotretinoin-induced nail changes and increase patients’ treatment compliance. A total of 200 patients diagnosed with acne vulgaris were included in the study. 100 of the patients were started systemic isotretinoin treatment and 100 control patients were receiving topical acne treatment. Age and gender of all of the participants, duration of treatment, total doses per month, and type of nail changes were recorded. Patients with persistent nail changes were followed at the 3rd and 6th months after treatment. A total of 34 patients had nail changes in the isotretinoin group. These changes included onychoschizia (55.9%), leukonychia (11.8%), onychorexis (8.8%), median nail dystrophy (5.9%), pyogenic granulomas (5.9%), chronic paronychia and granulation tissue (5.9%), onycholysis (2.9%) and Beau’s line (2.9%). The rate of nail changes in the isotretinoin group was significantly higher than in the topical treatment group (34% vs. 11%, p:0.001). Isotretinoin increases the risk of nail changes, primarily onychoschizia. The risk of developing nail changes is not associated with treatment duration but is associated with the total cumulative dose. Nail findings induced by isotretinoin are completely reversible.