Nicole C. Woitowich

The National Institutes of Health (NIH) Sex as a Biological Variable (SABV) policy aims to improve the rigor and reproducibility of biomedical research by encouraging sex-inclusive study designs and sex-based analyses. To evaluate policy implementation, we examine 574 funded publications (2017-2024) linked to grants from 21 NIH Institutes and Centers. We assess sex inclusion and sex-based reporting and analyses, while examining associations with author gender. Sixty-one percent of studies include both sexes, with human-subject research more likely to do so than non-human studies (p = 1.31×10^-23). Of the single-sex studies, 34% focus on sex-specific topics. Among studies to include both sexes, 83% report sample sizes by sex, yet only 44% conduct sex-based analyses. Sex-based analyses are more common in human-subject studies (p = 0.00002) and in articles with women first authors (50% vs. 39%, p = 0.036). Articles with women as first and last author dyads are significantly more likely to analyze data by sex (OR = 2.24, 95% CI: 1.33-3.79). These findings suggest that while the SABV policy has encouraged sex inclusion, gaps remain in sex-based analyses. Author gender may influence these research practices, underscoring the need for continued efforts to fully integrate SABV into NIH-funded research studies.

Background: Sex and gender are key variables which inform human health and disease. It remained unclear how sex and gender were considered, evaluated, reported, or analyzed within Covid-19 research. This article evaluates the proportion of Covid-19-related articles which highlighted sex- or gender-specific health content and examines associations with author gender. Materials and methods: Article records for 134,008 publications indexed in the LitCovid database were extracted on June 1^st, 2021. Metadata such as publication year, author names, and country of institutional affiliation were obtained from Elsevier’s SCOPUS database by matching PubMed Identifiers (PMIDs). Only articles with matching SCOPUS records were included in the study, resulting in a final sample of 94,488 articles. First and last author gender was assigned to a subset of 71,597 articles. Article title, abstracts, and keywords were screened for sex or gender-specific health content using a text-based search strategy. Descriptive statistics and regression analyses were used to study associations between author gender and the presence or absence of sex or gender-related health content. Results: Only 4% of Covid-19-related articles highlighted sex or gender-related health content. Papers with women first authors were more likely to highlight sex or gender-related health content compared to papers with men as first authors (4.15% n = 1,339 vs 3.68%, n = 1,997) [X² (1, n = 86,468) = 12,01, p = 0.0005]. Papers with women first and last authors had an increased probability of addressing sex or gender-related health with an odds ratio of 1.16 (95% CI 1.04 – 1.29). While there was no association between author gender and journal impact, articles which highlighted sex or gender-related health content were published in journals with higher CiteScores [Mdn = 5.0, Q1-Q3 (3.5–8.2) vs. Mdn = 4.7, Q1-Q3 (2.8–8.0)]. Conclusions: The paucity of publications to highlight sex or gender in the context of the Covid-19 pandemic is alarming. Research that focuses on the influence of sex and or gender is essential for advancing the scientific understanding of disease processes.

Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to 5 years. Using NIH data for the period 2006–2022, we report that ~230 K99 awards were made every year, representing up to ~$250 million annual investment. About 40% of K99 awardees were women and ~89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the United States.

Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to five years. Using NIH data for the period 2006-2022, we report that ∼230 K99 awards were made every year, representing up to ∼$250 million annual investment. About 40% of K99 awardees were women and ∼89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the US.

The impacts of science are felt across all socio-ecological levels, ranging from the individual to societal. In order to adapt or respond to scientific discoveries, novel technologies, or biomedical or environmental challenges, a fundamental understanding of science is necessary.

Biomedical scientists faced unprecedented challenges during the COVID-19 pandemic, analogous in many ways to their clinician colleagues.¹ Nevertheless, insufficient attention has been paid to adverse psychological consequences of the pandemic for scientists. We investigated whether resilience was associated with scientists’ professional and career setbacks during the pandemic.

Many postdoctoral fellows and scholars who hope to secure tenure-track faculty positions in the United States apply to the National Institutes of Health (NIH) for a Pathway to Independence Award. This award has two phases (K99 and R00) and provides funding for up to five years. Using NIH data for the period 2006-2022, we report that ∼230 K99 awards were made every year, representing up to ∼$250 million annual investment. About 40% of K99 awardees were women and ∼89% of K99 awardees went on to receive an R00 award annually. Institutions with the most NIH funding produced the most recipients of K99 awards and recruited the most recipients of R00 awards. The time between a researcher starting an R00 award and receiving a major NIH award (such as an R01) ranged between 4.6 and 7.4 years, and was significantly longer for women, for those who remained at their home institution, and for those hired by an institution that was not one of the 25 institutions with the most NIH funding. Shockingly, there has yet to be a K99 awardee at a historically Black college or university. We go on to show how K99 awardees flow to faculty positions, and to identify various factors that influence the future success of individual researchers and, therefore, also influence the composition of biomedical faculty at universities in the US.

Regardless of which career path a scientist decides to take, they must be able to communicate effectively with broad audiences. As such, science communication training has become an essential component of STEM professional development. While multiple national scientific societies have articulated the need to address these skills as in fundamental training, few undergraduate scientific training programs have formally addressed this in their degree programs. Here we present an innovative approach to teach this skill set by blending an online science communication course with existing curricula in the biomedical sciences. Online content from the American Society for Biochemistry and Molecular Biology (ASBMB) Art of Science Communication (ASC) course was integrated into an undergraduate setting. This new iteration utilized components from the successful online course format blended with an institutional course to foster science communication skills. We provide key insights into blended-course development and its impact on learners’ professional development and science communication skills. We contextualize our approach with what others have learned from blended courses and online professional development opportunities for STEM students.