Darya Radziuk

Представлен метод электромагнитной активизации молекул салициловой кислоты per se (СК) посредством ультразвукового (20 кГц) комплексообразования с оксидированной цинк-графеновой структурой. Результатом разработки явились сформированные наночастицы «ZnO – частично восстановленный кислородсодержащий графен (кГ) – СК» со средним размером (5,53 ± 0,11) нм и гексагональной сингонией типа вюрцита оксида цинка с комплексами молекул салициловой кислоты. Комплексообразование салициловой кислоты с матрицей «ZnO – кГ» приводит к усилению электромагнитного поля салициловой кислоты в 10² раза с локальным увеличением при контакте с ZnO в 10³ раза и, как следствие, к избирательной электромагнитной активизации молекул лекарственного вещества. Разработанный метод формирования наночастиц с составом «ZnO – кГ – СК» можно применить ко многим другим лекарственным соединениям и устройствам на их основе, что представляет большой интерес для медицинской электроники и наномедицины.

An ultrasonic method (20 kHz) is introduced to activate pristine ibuprofen organic molecular crystals via complexation with silver in nitrogen-doped oxidized graphene nanoplatforms (similar to 50 nm). Ultra-sonic complexation occurs in a single-step procedure through the binding of the carboxylic groups with Ag and H-bond formation, involving noncovalent pi C=C -> pi C=C* transitions in the altered phenyl ring and pi PY -> pi CO* in ibuprofen occurring between the phenyl ring and C-O bonds as a result of interaction with hydroxyl radicals. The ibuprofen-silver complex in << NrGO >> exhibits a similar to 42 times higher acceleration rate than free ibuprofen of the charge transfer between hexacyanoferrate and thiosulfate ions. The increased acceleration rate can be caused by electron injection/ejection at the interface of the << Ag-NrGO >> nanoplatform and formation of intermediate species (Fe(CN)5(CNSO3)x- with x = 4 or 5 and AgHS2O3) at the excess of produced H+ ions. Important for microwave chemotherapy, ibuprofen-silver complexes in the << NrGO >> nanoplatform can produce H+ ions at similar to 12.5 times higher rate at the applied voltage range from 0.53 to 0.60 V. << Ibu-Ag-NrGO >> NPs develop similar to 105 order higher changes of the electric field strength intensity than free ibuprofen in the microwave absorption range of 100-1000 MHz as revealed from the theoretical modeling of a cervix tumor tissue.

We demonstrate a single-step ultrasonic in situ complexation of salicylic acid during the growth of Fe₃O₄-reduced graphene oxide nanoparticles (∼10 nm) to improve the antioxidant and antiproliferative effects of pristine drug molecules. These nanoparticles have a precisely defined electronic molecular structure with salicylic acid ligands specifically complexed to Fe(III)/Fe(II) sites, four orders of magnitude larger electric surface potential, and enzymatic activity modulated by ascorbic acid molecules. The diminishing efficiency of hydroxyl radicals by Fe₃O₄-rGO-SA nanoparticles is tenfold higher than that by pristine salicylic acid in the electro-Fenton process. The H⁺ production of these nanoparticles can be switched by the interaction with ascorbic acid ligands and cause the redox deactivation of iron or enhanced antioxidation, where rGO plays an important role in enhanced charge transfer catalysis. Fe₃O₄-rGO-SA nanoparticles are nontoxic to erythrocytes, i.e., human peripheral blood mononuclear cells, but surpassingly inhibit the growth of three cancer cell lines, HeLa, HepG2, and HT29, with respect to pristine salicylic acid molecules.

A feasible sonochemical method is developed for the complexation of nonsteroidal anti-inflammatory drug ketorolac with the Fe ₃ O ₄ –graphene oxide nanocomposite.

A feasible sonochemical approach is described for the preparation of copper/iron‐modified graphene oxide nanocomposites through ultrasonication (20 kHz, 18 W cm⁻²) of an aqueous solution containing copper and iron ion precursors. Unique copper‐, copper/iron‐ and iron‐modified graphene oxide nanocomposites have a submicron size that is smaller than that of pristine GO and a higher surface area enriched with Cu₂O, CuO, and Fe₂O₃ of multiform phases (α‐, β‐, ϵ‐, or γ), FeO(OH), and sulfur‐ or carbon‐containing compounds. These nanocomposites are sonochemically intercalated with the nonsteroidal anti‐inflammatory drug ketorolac, which results in the formation of nanoscale carriers. Ketorolac monotonically disintegrates from these nanoscale carriers in aqueous solution upon adjustment of the pH from 1 to 8. The disintegration of ketorolac proceeds at a slower rate from the copper/iron‐modified graphene oxide at increased pH, but at a faster rate from the iron‐modified graphene oxide under acidic conditions.