Muhammad Akhtar Tarar

Colorectal cancer is challenging to treat because many anticancer drugs do not achieve optimal therapeutic effects. Moreover, these drugs can cause systemic side effects, and patients often respond differently to treatment. This study provides a computational framework that merges quantitative structure property relationship analysis with a computational methodology combining structural descriptors and ranking analysis to systematically analyze and rank 10 United States Food and Drug Administration approved medicines for colorectal cancer. A suite of degree-based and neighborhood degree-based topological indices were generated and examined for their association with essential physicochemical properties, specially molecular weight and molecular complexity. Correlation research revealed that specific degree-based indices, and neighborhood degree-based indices, exhibited strong predictive power for these properties. By employing ratio weighting alongside with the VIekriterijumsko Kompromisno Rangiranje and Technique for Order Preference by Similarity to Ideal Solution decision techniques, the medicines were ranked based on their predicted physicochemical performance. The results from both decision methods consistently showed fluorouracil as the highest ranked therapeutic agent, followed by tipiracil hydrochloride and bevacizumab, underlining their favorable structural and pharmacological properties. This comprehensive modelling technique provides a consistent and systematic strategy to aid in early-phase drug screening and inform decision-making in colorectal cancer therapy.

The Biswas–Mollivic equation is a special type of nonlinear Schrödinger equation, which explains the spatio-temporal behaviour of excitable media. In this paper, we investigate the optical soliton solutions of the Biswas–Mollivic equation with cubic–quintic–septic–nonic nonlinearities using the generalized Riccati equation mapping method. This method is efficient and provides new perspectives. It also provides novel insights into the dynamics of excitable media. Our findings add to a better understanding of the complex spatio-temporal patterns that develop in excitable media and have potential applications in the design of new technologies for controlling and manipulating pattern formation. To depict optical soliton solutions graphically, we use the MATLAB software.

Journal provides a multidisciplinary forum for scientists, researchers and engineers involved in research and design of nonlinear processes and phenomena, including the nonlinear modelling of phenomena of the nature.