Sabri Colak

The aim of this study was to investigate the relationship between tear function changes and meibomian gland dysfunction in various phenotypes of polycystic ovary syndrome (PCOS). In this prospective case–control study, 4 separate case groups were formed for 4 different phenotypes of PCOS, which are variants of clinical presentation. A total of 160 women were included in the study, 32 women for each group and 32 healthy women as control group. Ocular surface disease index (OSDI), Oxford score for corneal and conjunctival involvement, Schirmer 1 and 2 tests, noninvasive tear breakup time (NIBUT), lower lid meibomian drop-out grades by non-contact meibography, and meibomian gland disease (MGD) distortion and shortening scores were compared between all groups. When the PCOS group was compared with the control group, phenotype A showed the most significant differences in NIBUT (p = 0.003), MGD (p = 0.002) and OSDI (p = 0.004). Although the mean Schirmer 1 and Schirmer 2 tests value were lower in the PCOS group compared to the control group, no significant difference was detected in any phenotype (p = 0.911, p = 0.117). A statistically significant weak negative correlation was observed between NIBUT and OSDI values (r = − 0.206, p = 0.027). There was a statistically significant positive and very weak correlation between OSDI and BMI (r = 0.079, p = 0.041). Tear film instability attributed to MGD was found to be significantly different in all PCOS patients compared to healthy subjects regardless of phenotype, and this difference was statistically higher in phenotype A.

The objective of this study was to evaluate anterior segment parameters across various phenotypes of polycystic ovary syndrome (PCOS), considering body mass index (BMI), serum estradiol and testosterone levels. This prospective study included 116 women with PCOS, with each of the four distinct phenotype comprising 29 women. Additionally, 29 healthy women were included in the control group. All participants underwent comprehensive ophthalmologic examinations, including intraocular pressure (IOP) measurements. Anterior segment parameters, such as central corneal thickness (CCT), axial length (AL), aqueous depth (AD), anterior chamber depth (ACD), and lens thickness (LT) were measured using optic biometry. Endothelial cell density (ECD) was assessed using non-contact specular microscopy. The BMI was calculated, and serum levels of estradiol and testosterone were noted. IOP was found to be significantly higher (p = 0.003) and CCT was significantly thicker (p = 0.004) in all phenotypes of PCOS compared to the control group. BMI, serum estradiol and free testosterone were found to correlate with both IOP and CCT. AL, AD, ACD and LT values showed no significant differences compared to the control group. Although ECD tend to be higher in the PCOS phenotypes, this difference was not statistically significant (p > 0.05). Given our findings that CCT and IOP are significantly elevated in PCOS phenotypes. PCOS should be considered as an important factor when evaluating female patients for anterior segment diseases and glaucoma.

Menstrual psychosis (MP) is a condition that is associated with the menstrual cycle and can cause significant mental changes. Information about diagnosis and treatment approaches is limited. MP, which is generally reported to occur in young women around the age of 16, typically has an acute onset consistent with the premenstrual cycle, with short-term psychotic symptoms, and a clinical appearance that ends within a few days of discontinuation of menstruation bleeding. In addition to psychotic symptoms, patients may have significant mood symptoms. In this study, a 42-year-old female patient presented to the psychiatry outpatient clinic with complaints of suspicion of people, thinking that she would see them evil, inability to focus, attention, lack of willingness and insomnia. The patient reported that each of these symptoms occurred during her premenstrual period. Unlike other studies, our case is of adult age. We believe that our study will contribute to the current literature.

The aim of this study was to evaluate the resistin concentrations in saliva; which is a noninvasive and stress-free diagnostic sample, and to investigate the significance of salivary resistin conce...

Objective: Aims of the study is to specify the significance of thiol/disulfide homeostasis in the aspect of gestational diabetes mellitus (GDM) and GDM-related complications. Material and Methods: This study is a prospective review of the data of 61 healthy and non-pregnant women, 58 healthy pregnant women, and 62 pregnant women with GDM. Results: The patients with gestational diabetes mellitus had significantly higher disulfide/native thiol and disulfide/total thiol concentrations than non-pregnant patients (p<0.001 for both) and healthy pregnant patients (p: 0.015 and p: 0.018, respectively). Besides, in GDM group had significantly lower native thiol/total thiol concentrations than non-pregnant patients and healthy pregnant patients (p<0.001 and p: 0.016, respectively). There were positive and significant correlations between disulfide levels and HbA1c concentrations (r=0.26, p: 0.042), and between disulfide and oral glucose tolerance test first hour concentrations (r=0.26, p: 0.039). The receiver operating characteristic curve analyses for native thiol, total thiol, and disulfide were unable to predict adverse perinatal outcomes in this cohort. Conclusion: The significantly higher concentrations of disulfide/native thiol and disulfide/total thiol in women with GDM could be considered as the presence of increased oxidative stress. However, these markers failed to predict adverse perinatal outcomes. Keywords: gestational diabetes mellitus; oxidative stress; perinatal outcome; pregnancy; thiol/disulfide homeostasis

Objective: The present study was designed to determine the seroprevalance of Toxoplasma gondii, Rubella, and cytomegalovirus, to investigate the frequency of low and high avidity results among pregnant women and to contribute to the data of our country with the results obtained.Study Design: In the present study, the hospital records of the women who applied to the antenatal outpatient of the Rize Recep Tayyip Erdoğan University Medical Faculty during the first trimester between January 2016 and October 2018 were retrospectively reviewed. Toxoplasma gondii, RRubella and cytomegalovirus IgM, IgG and IgG avidity results were evaluated.Result: IgM positivity was found to be 0.83% (29/3490) for Toxoplasma gondii, 0.92% (32/3459) for Rubella and 1.90% (65/3404) for cytomegalovirus; IgG positivity was found to be 33.64% (1174/3490) for Toxoplasma gondii, 90.70% for Rubella (3140/3459), and 99.17% (3376/3404) for cytomegalovirus. Avidity of Toxoplasma gondii was found to be low (3.70%) in 1 patient, borderline (11.11%) in 3 patients, and high avidity in 23 patients (85.18%). Avidity of cytomegalovirus was found to be low (1.75%) in 1 patient, borderline (3.50%) in 2 patients and high avidity (94.73%) in 54 patients. Avidity of Rubella was found to be low (4%) in 1 patient, and high avidity (96%) was found in 24 patients.Conclusions: In our study, although the prevalence of acute infection with Rubella, cytomegalovirus and Toxoplasma gondii was shown to be low in pregnancy in Rize province, serological screening tests for monitoring and informing high-risk groups that are particularly seronegative appear to be important.