Martin Shahid
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Martin Shahid has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Snejina Vassileva
Department of Dermatology and Venereology, Medical University - Sofia, Sofia, Bulgaria
2 shared publications - Ekaterina Ivanova-Todorova
Laboratory of Clinical Immunology, University Hospital “St. Ivan Rilski”, Department of Clinical Immunology, Medical University of Sofia, 1431 Sofia, Bulgaria
1 shared publication - Iskra Altankova
Medical Faculty, Sofia University “St. Kliment Ohridski”, 1407 Sofia, Bulgaria
1 shared publication - Kalina Tumangelova-Yuzeir
Laboratory of Clinical Immunology “St Ivan Rilski” University Hospital Sofia Bulgaria
1 shared publication Kossara Drenovska
1 shared publication- Kossara Drenovska
Department of Dermatology and Venereology, Medical University, Sofia, Bulgaria
1 shared publication
Latest Publications
- 8 May 2023
- Published by Morressier GmbH
ISID0171 - Paraneoplastic pemphigus: Clinical, pathologic, and immunopathologic features in a series of twelve Bulgarian patients.
Paraneoplastic pemphigus (PNP) also called Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS), is a rare but severe clinical variant of pemphig | POSTER
- 8 May 2023
- Published by Morressier GmbH
ISID0171 - Paraneoplastic pemphigus: Clinical, pathologic, and immunopathologic features in a series of twelve Bulgarian patients.
Paraneoplastic pemphigus (PNP) also called Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS), is a rare but severe clinical variant of pemphig | POSTER
- Open Access
- 17 September 2021
- Published by Morressier GmbH
ESDR184 - HLA-DQB1 associations among Bulgarian patients with dermatitis herpetiformis
Dermatitis herpetiformis (DH) is a rare autoimmune bullous dermatosis. There are only few HLA studies among DH patients and data among the Bulgarian population are scarce. Research in the field has indicated DH association with HLA DQ2 (DQA1*05:01 & DQB1*02) and DQ8 (DQA1*03:01 & DQB1*03:02) in Caucasians. The aim of our study was to evaluate the HLA-DQB1 typing among Bulgarian DH
- 17 September 2021
- Published by Morressier GmbH
Open AccessESDR184 - HLA-DQB1 associations among Bulgarian patients with dermatitis herpetiformis
Dermatitis herpetiformis (DH) is a rare autoimmune bullous dermatosis. There are only few HLA studies among DH patients and data among the Bulgarian population are scarce. Research in the field has indicated DH association with HLA DQ2 (DQA1*05:01 & DQB1*02) and DQ8 (DQA1*03:01 & DQB1*03:02) in Caucasians. The aim of our study was to evaluate the HLA-DQB1 typing among Bulgarian DH
- Open Access
Celiac-Related Autoantibodies and IL-17A in Bulgarian Patients with Dermatitis Herpetiformis: A Cross-Sectional Study
Background and objectives: Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD). The aim of the present study was to explore the performance of a panel of CD-related antibodies and IL-17A in Bulgarian patients with DH. Materials and Methods: Serum samples from 26 DH patients at mean age 53 ± 15 years and 20 healthy controls were assessed for anti-tissue transglutaminase (anti-tTG), anti-deamidated gliadin peptides (anti-DGP), anti-actin antibodies (AAA), and IL-17A by enzyme linked immuno-sorbent assay (ELISA), as well as anti-tTG, anti-gliadin (AGA), and anti-Saccharomyces cerevisiae antibodies (ASCA) using immunoblot. Results: The average serum levels of anti-tTG, anti-DGP, AGA, AAA, and the cytokine IL-17A were at significantly higher levels in patients with DH compared to the average levels in healthy persons which stayed below the cut-off value (p < 0.05). Anti-DGP and anti-tTG antibodies showed the highest diagnostic sensitivity and specificity, as well as acceptable positive and negative predictive value. None of the healthy individuals was found positive for the tested antibodies, as well as for ASCA within the DH group. All tests showed good to excellent correlations (r = 0.5 ÷ 0.9, p < 0.01). Conclusions: Although the diagnosis of DH relies on skin biopsy for histology and DIF, serologic testing of a panel of celiac-related antibodies could be employed with advantages in the diagnosing process of DH patients. Furthermore, DH patients who are positive for the investigated serologic parameters could have routine monitoring for gastrointestinal complications typical for the gluten-sensitive enteropathy.
Open AccessCeliac-Related Autoantibodies and IL-17A in Bulgarian Patients with Dermatitis Herpetiformis: A Cross-Sectional Study
Background and objectives: Dermatitis herpetiformis (DH) is a blistering dermatosis, which shares common immunologic features with celiac disease (CD). The aim of the present study was to explore the performance of a panel of CD-related antibodies and IL-17A in Bulgarian patients with DH. Materials and Methods: Serum samples from 26 DH patients at mean age 53 ± 15 years and 20 healthy controls were assessed for anti-tissue transglutaminase (anti-tTG), anti-deamidated gliadin peptides (anti-DGP), anti-actin antibodies (AAA), and IL-17A by enzyme linked immuno-sorbent assay (ELISA), as well as anti-tTG, anti-gliadin (AGA), and anti-Saccharomyces cerevisiae antibodies (ASCA) using immunoblot. Results: The average serum levels of anti-tTG, anti-DGP, AGA, AAA, and the cytokine IL-17A were at significantly higher levels in patients with DH compared to the average levels in healthy persons which stayed below the cut-off value (p < 0.05). Anti-DGP and anti-tTG antibodies showed the highest diagnostic sensitivity and specificity, as well as acceptable positive and negative predictive value. None of the healthy individuals was found positive for the tested antibodies, as well as for ASCA within the DH group. All tests showed good to excellent correlations (r = 0.5 ÷ 0.9, p < 0.01). Conclusions: Although the diagnosis of DH relies on skin biopsy for histology and DIF, serologic testing of a panel of celiac-related antibodies could be employed with advantages in the diagnosing process of DH patients. Furthermore, DH patients who are positive for the investigated serologic parameters could have routine monitoring for gastrointestinal complications typical for the gluten-sensitive enteropathy.