Priyanka Parmar
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Priyanka Parmar has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Alina Rodriguez
MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
1 shared publication - Caroline L. Relton
London School of Hygiene & Tropical Medicine, London, UK
1 shared publication - Faisal Ibne Rezwan
Department of Computer Science, Aberystwyth University, Aberystwyth, UK
1 shared publication - John W. Holloway
Human Development and Health, University of Southampton, Southampton, UK
1 shared publication - Juha Veijola
Research Unit of Clinical Medicine, Psychiatry, University of Oulu, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland; Department of Psychiatry, Oulu University Hospital, Oulu, Finland
1 shared publication - Karl-Heinz Herzig
Research Unit of Biomedicine and Internal Medicine Faculty of Medicine University of Oulu Oulu Finland
1 shared publication
Latest Publications
- Open Access
- 1 July 2019
- Published by Springer Nature in Clinical Epigenetics
- Vol. 11 (1) , 1-16
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring. We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes. DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.
- 1 July 2019
- Published by Springer Nature in Clinical Epigenetics
- Vol. 11 (1) , 1-16
Open AccessDNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring. We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes. DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.