John Paul V. Anders

Bilateral (BL) and unilateral (UL) muscle actions are commonly incorporated in training programs to achieve distinct goals, however, the mechanisms driving modality-specific training adaptations remain unclear. This study examined peak force, electromyographic (EMG) amplitude (AMP), and mean power frequency (MPF) of the non-dominant leg during isokinetic leg extensions performed as either a BL or BLUL combined modality. Twelve recreationally trained men (Mean ± SD; age = 20.8 ± 1.7 years; weight = 83.1 ± 15.7 kg; height = 178.2 ± 7.8 cm) attended 2 test visits that included BL and UL maximal isokinetic leg extensions at 180°·s⁻¹ followed by a fatiguing task of either 50 BL or 25 BL followed immediately by 25 UL (BLUL) maximal, isokinetic leg extensions at 180°·s⁻¹, in random order on separate days. The results demonstrated a 33.3% decline in peak force with a concomitant increase in EMG AMP across the fatiguing task, but there were no significant differences between conditions. For EMG MPF, the BLUL condition exhibited a 19.39% decline versus a 10.97% decline in the BL condition. Overall, the present study suggested there were no significant differences in neuromuscular activation strategies between the tested modalities. However, our findings indicated that incorporating UL muscle actions after a BL task may induce a greater degree of peripheral fatigue compared to sustained BL muscle actions. Practitioners might consider implementing UL exercises at the end of a training bout to induce greater metabolic stress.

Anders, JPV, Neltner, TJ, Smith, RW, Arnett, JE, Housh, TJ, Schmidt, RJ, and Johnson, GO. Unilateral and bilateral isokinetic leg extensions exhibit no differences in neuromuscular activation under maximal and fatiguing conditions. J Strength Cond Res 38(3): 474–480, 2024—The bilateral deficit is a phenomenon where force production during a bilateral (BL) muscle action is less than the sum of force produced when the muscle action is performed unilaterally (UL) with both limbs. The purpose of this study was to compare peak force, electromyographic (EMG) amplitude (AMP), and mean power frequency (MPF) of the nondominant leg between UL and BL isokinetic leg extensions. Eleven recreationally trained men (mean ± SD; age = 20.8 ± 1.7 years; body mass = 84.0 ± 16.2 kg; height = 179.3 ± 7.2 cm) volunteered to participate in this study. The 2 test visits included UL and BL maximal isokinetic leg extensions at 180°·second⁻¹ followed by a fatiguing task of either 50 UL or 25 UL followed immediately by 25 BL (ULBL) maximal, isokinetic leg extensions at 180°·second⁻¹, in random order on separate days. The results demonstrated a significant (p = 0.015, = 0.460) bilateral deficit in force (UL = 56.29 ± 11.20 kg; BL = 50.32 ± 7.35 kg; d = 0.63; 95% CI [1.42, 10.52]) but no significant bilateral deficit in EMG AMP (p = 0.892, = 0.002). The peak force during the fatiguing task demonstrated a significant main effect for repetition (p < 0.001, = 0.943) characterized by a reduced peak force from repetitions 20–50. Similarly, EMG MPF demonstrated a significant main effect for repetition (p < 0.001, = 0.702) characterized by a reduced EMG MPF from repetitions 35–50. There were no significant effects (p = 0.102–0.387, = 0.096–0.203) for EMG AMP. These findings suggested that the bilateral deficit was not associated with a neuromuscular deficit and UL muscle actions may be used to potentiate force production of subsequent BL muscle actions.

This study examined the effects of joint angle (JA) on maximal voluntary isometric contraction (MVIC) and neuromuscular responses following fatiguing tasks anchored to RPE. Nine men (mean ± SD: age = 20.7 ± 1.2 yrs) performed forearm flexion MVICs at elbow JAs of 75° and 125° before and after sustained, isometric forearm flexion tasks to failure at fatiguing joint angles (FJA) of 75° and 125° anchored to RPE = 8. The amplitude and frequency of the electromyographic and mechanomyographic signals were recorded. Neuromuscular efficiency was calculated by dividing normalized torque by normalized electromyographic amplitude. A dependent t-test was used to assess the mean difference for time to task failure (TTF) between FJA. Repeated measure ANOVAs were used to assess mean differences for pre-test to post-test MVIC and neuromuscular responses. There was no significant difference between FJA for TTF (p = 0.223). The MVIC (collapsed across FJA and MVIC JA) decreased from pre-test to post-test (51.1 ± 5.0 vs. 45.3 ± 5.6 Nm, p < 0.001). Normalized neuromuscular parameters remained unchanged (p > 0.05). The FJA resulted in similar torque and neuromuscular responses, and the decreases in MVIC were not tracked by changes in the neuromuscular parameters. Thus, the neuromuscular parameters were not sensitive to fatigue, and pre-test to post-test measures may be compared between different FJA.

The present study examined the effect of anchor schemes on the time to task failure (TTF), performance fatigability, neuromuscular responses, and the perceived sensations that contributed to task termination following the sustained, isometric forearm flexion tasks. Eight women completed sustained, isometric forearm flexion tasks anchored to RPE = 8 (RPEFT) and the torque (TRQFT) that corresponded to RPE = 8. The subjects performed pre-test and post-test maximal isometric contractions to quantify performance fatigability and changes in electromyographic amplitude (EMG AMP) and neuromuscular efficiency (NME). In addition, the subjects completed a post-test questionnaire (PTQ) to quantify the contributions of perceived sensations to task termination. Repeated measure ANOVAs were used to assess the mean differences for TTF, performance fatigability, and neuromuscular responses. Wilcoxon Signed Rank Tests were used to assess the differences between anchor schemes for the average values from the PTQ item scores. For TTF, the RPEFT was longer than the TRQFT (174.9 ± 85.6 vs. 65.6 ± 68.0 s; p = 0.006). Collapsed across the anchor scheme, there were decreases in torque (23.7 ± 5.5 Nm vs. 19.6 ± 4.9 Nm; p < 0.001) and NME (1.00 ± 0.00 vs. 0.76 ± 0.15; p = 0.003). There were no significant (p > 0.577) changes for EMG AMP. For the PTQ, there were no differences (p > 0.05) between anchor schemes. There were, however, inter-individual differences in the response scores. The current findings indicated that performance fatigability was likely due to peripheral fatigue (based on NME), not central fatigue (based on EMG AMP). Furthermore, the use of a PTQ may serve as a simple tool to assess the contributions of perceived sensations to task termination.

Numerous studies have demonstrated the efficacy of creatine supplementation for improvements in exercise performance. Few studies, however, have examined the effects of phosphocreatine supplementation on exercise performance. Furthermore, while polyphenols have antioxidant and anti-inflammatory properties, little is known regarding the influence of polyphenol supplementation on muscular strength, power, and endurance. Thus, the purpose of the present study was to compare the effects of 28 days of supplementation with phosphocreatine disodium salts plus blueberry extract (PCDSB), creatine monohydrate (CM), and placebo on measures of muscular strength, power, and endurance. Thirty-three men were randomly assigned to consume either PCDSB, CM, or placebo for 28 days. Peak torque (PT), average power (AP), and percent decline for peak torque (PT%) and average power (AP%) were assessed from a fatigue test consisting of 50 maximal, unilateral, isokinetic leg extensions at 180°·s− 1 before and after the 28 days of supplementation. Individual responses were assessed to examine the proportion of subjects that exceeded a minimal important difference (MID). The results demonstrated significant (p < 0.05) improvements in PT for the PCDSB and CM groups from pre- (99.90 ± 22.47 N·m and 99.95 ± 22.50 N·m, respectively) to post-supplementation (119.22 ± 29.87 N·m and 111.97 ± 24.50 N·m, respectively), but no significant (p = 0.112) change for the placebo group. The PCDSB and CM groups also exhibited significant improvements in AP from pre- (140.18 ± 32.08 W and 143.42 ± 33.84 W, respectively) to post-supplementation (170.12 ± 42.68 W and 159.78 ± 31.20 W, respectively), but no significant (p = 0.279) change for the placebo group. A significantly (p < 0.05) greater proportion of subjects in the PCDSB group exceeded the MID for PT compared to the placebo group, but there were no significant (p > 0.05) differences in the proportion of subjects exceeding the MID between the CM and placebo groups or between the CM and PCDSB groups. These findings indicated that for the group mean responses, 28 days of supplementation with both PCDSB and CM resulted in increases in PT and AP. The PCDSB, however, may have an advantage over CM when compared to the placebo group for the proportion of individuals that respond favorably to supplementation with meaningful increases in muscular strength.

Purpose Literature is conflicted on whether electromechanical delay durations decrease following resistance training programs. Therefore, the aim of this study is to examine the contributions and durations of the electrochemical (EMD_E-M) and mechanical (EMD_M-F) components to the overall electromechanical delay (EMD_E-F) during step isometric muscle actions following 4-weeks of structured, multi-joint, lower-body variable resistance training (VRT) program. Methods Twelve men performed 4-weeks of VRT leg press training utilizing combination of steel plates (80% total load) and elastic bands (20% total load). Training consisted of 3 sets of 10 repetitions at a 10 repetition maximum load, 3 day week⁻¹ for 4-weeks. EMD_E-M, EMD_M-F, and EMD_E-F was measured at Baseline, Week-2, and Week-4 during voluntary step isometric muscle actions (20, 40, 60, 80, and 100% of maximal voluntary isometric contraction) from the vastus lateralis using electromyographic, mechanomyographic, and force signals. Results The EMD_E-M, EMD_M-F, and EMD_E-F exhibited decreases in duration following 4-weeks of VRT. In addition, EMD_E-M contributed significantly less (42–47%) than EMD_M-F (53–58%) to the total duration of EMD_E-F across the 4-weeks of VRT. Conclusions These findings indicated that a structured, VRT program utilizing multi-joint exercise was sufficient to induce decreases in the electrochemical and mechanical processes associated with step isometric muscle contractions. In addition, the utilization of the electromyographic, mechanomyographic, and force signals were capable of quantifying electrochemical and mechanical component changes associated with voluntary muscle contraction. Thus, EMD_E-M, EMD_M-F, and EMD_E-F can be useful in quantifying physiological changes in athletic, clinical, and applied research interventions.

The purpose of the current study was to determine if, and to what extent, sex differences in performance fatigability after a sustained, bilateral leg extension, anchored to a moderate rating of perceived exertion (RPE), could be attributed to muscle size, muscular strength, or pain pressure threshold (PPT) in young, healthy adults. Thirty adults (men: n = 15, women: n = 15) volunteered to complete a sustained leg extension task anchored to RPE = 5 (10-point OMNI scale) as well as pretest and posttest maximal voluntary isometric contraction (MVIC) trials. The fatigue-induced decline in MVIC force was defined as performance fatigability. We used muscle cross-sectional area (mCSA) to quantify muscle size and a dolorimeter to assess PPT. The sustained task induced fatigue such that both men and women exhibited significant (p < 0.05) decreases in MVIC force from pretest to posttest (M = 113.3, SD =24.2 kg vs. M = 98.3, SD = 23.1 kg and M = 73.1, SD =14.5 kg vs. M = 64.1, SD = 16.2 kg, respectively), with no significant sex differences in performance fatigability (grand M = 12.6, SD =10.6%). Men, however, exhibited significantly (p < 0.05) longer time to task failure (TTF) than women (M = 166.1, SD =83.0 seconds vs. M = 94.6, SD =41.7) as well as greater PPT (M = 5.9, SD = 2.2 kg vs. M = 3.4, SD =1.1 kg). The only significant predictor of performance fatigability was PPT. In conclusion, differences in PPT, at least in part, mediate variations in TTF during self-paced exercise anchored to a specific RPE and resulting in performance fatigability.

The purpose of the present study was to examine the influence of an acute bout of high-intensity resistance exercise on measures of cognitive function. Ten men (Mean ± SD: age = 24.4 ± 3.2 yrs; body mass = 85.7 ± 11.8 kg; height = 1.78 ± 0.08 m; 1 repetition maximum (1RM) = 139.0 ± 24.1 kg) gave informed consent and performed a high-intensity 6 sets of 10 repetitions of barbell back squat exercise at 80% 1RM with 2 minutes rest between sets. The Automated Neuropsychological Assessment Metrics (ANAM) was completed to assess various cognitive domains during the familiarization period, immediately before, and immediately after the high-intensity resistance exercise bout. The repeated measures ANOVAs for throughput scores (r·m-1) demonstrated significant mean differences for the Mathematical Processing task (MTH; p < 0.001, η2p = 0.625) where post hoc pairwise comparisons demonstrated that the post-fatigue throughput (32.0 ± 8.8 r·m-1) was significantly greater than the pre-fatigue (23.8 ± 7.4 r·m-1, p = 0.003, d = 1.01) and the familiarization throughput (26.4 ± 5.3 r·m-1, p = 0.024, d = 0.77). The Coded Substitution-Delay task also demonstrated significant mean differences (CDD; p = 0.027, η2p = 0.394) with post hoc pairwise comparisons demonstrating that the post-fatigue throughput (49.3 ± 14.4 r·m-1) was significantly less than the pre-fatigue throughput (63.2 ± 9.6 r·m-1, p = 0.011, d = 1.14). The repeated measures ANOVAs for reaction time (ms) demonstrated significant mean differences for MTH (p < 0.001, η2p = 0.624) where post hoc pairwise comparisons demonstrated that the post-fatigue reaction time (1885.2 ± 582.8 ms) was significantly less than the pre-fatigue (2518.2 ± 884.8 ms, p = 0.005, d = 0.85) and familiarization (2253.7 ± 567.6 ms, p = 0.009, d = 0.64) reaction times. The Go/No-Go task demonstrated significant mean differences (GNG; p = 0.031, η2p = 0.320) with post hoc pairwise comparisons demonstrating that the post-fatigue (285.9 ± 16.3 ms) was significantly less than the pre-fatigue (298.5 ± 12.1 ms, p = 0.006, d = 0.88) reaction times. High-intensity resistance exercise may elicit domain-specific influences on cognitive function, characterized by the facilitation of simple cognitive tasks and impairments of complex cognitive tasks.