Zhuoru Wu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Zhuoru Wu has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
Abhijit Bugde
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publicationBray Denard
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publicationDavid L. Garbers
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publicationGürol M. Süel
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publicationKatherine Luby-Phelps
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publicationLaura A. Molyneux
Cecil H. and Ida Green Center for Reproductive Biology Sciences, 2Department of Pharmacology, 3Live Cell Imaging Core Facility, 4Department of Cell Biology, 5Green Center Division for Systems Biology, and 6Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390
1 shared publication
Latest Publications
- Open Access
- 9 November 2009
- Published by Rockefeller University Press in Journal of Cell Biology
- Vol. 187 (4) , 513-524
Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells
Mammalian spermatogenesis is initiated and sustained by spermatogonial stem cells (SSCs) through self-renewal and differentiation. The basic question of whether SSCs have the potential to specify self-renewal and differentiation in a cell-autonomous manner has yet to be addressed. Here, we show that rat SSCs in ex vivo culture conditions consistently give rise to two distinct types of progeny: new SSCs and differentiating germ cells, even when they have been exposed to virtually identical microenvironments. Quantitative experimental measurements and mathematical modeling indicates that fate decision is stochastic, with constant probability. These results reveal an unexpected ability in a mammalian SSC to specify both self-renewal and differentiation through a self-directed mechanism, and further suggest that this mechanism operates according to stochastic principles. These findings provide an experimental basis for autonomous and stochastic fate choice as an alternative strategy for SSC fate bifurcation, which may also be relevant to other stem cell types.
- 9 November 2009
- Published by Rockefeller University Press in Journal of Cell Biology
- Vol. 187 (4) , 513-524
Open AccessCapacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells
Mammalian spermatogenesis is initiated and sustained by spermatogonial stem cells (SSCs) through self-renewal and differentiation. The basic question of whether SSCs have the potential to specify self-renewal and differentiation in a cell-autonomous manner has yet to be addressed. Here, we show that rat SSCs in ex vivo culture conditions consistently give rise to two distinct types of progeny: new SSCs and differentiating germ cells, even when they have been exposed to virtually identical microenvironments. Quantitative experimental measurements and mathematical modeling indicates that fate decision is stochastic, with constant probability. These results reveal an unexpected ability in a mammalian SSC to specify both self-renewal and differentiation through a self-directed mechanism, and further suggest that this mechanism operates according to stochastic principles. These findings provide an experimental basis for autonomous and stochastic fate choice as an alternative strategy for SSC fate bifurcation, which may also be relevant to other stem cell types.