Ofir Atrakchi
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Ofir Atrakchi has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
Joachim Smollich
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
1 shared publication- Ronen Alon
Department of Immunology and Regenerative Biology, Weizmann Institute of Science
1 shared publication - Sara W. Feigelson
Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
1 shared publication - Shiri Karagach
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
1 shared publication - Stav Kozlovski
Department of Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel
1 shared publication - Tamar Geiger
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
1 shared publication
Latest Publications
- Open Access
- 20 June 2025
- Published by Elsevier in Molecular & Cellular Proteomics
- Vol. 24 (7) , 101018
High-Throughput Single-Cell Proteomics of In Vivo Cells
- 20 June 2025
- Published by Elsevier in Molecular & Cellular Proteomics
- Vol. 24 (7) , 101018
Open AccessHigh-Throughput Single-Cell Proteomics of In Vivo Cells
- Open Access
- 1 January 2019
- Published by Taylor & Francis in Cell Adhesion & Migration
- Vol. 13 (1) , 314-320
Stable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo
It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturating levels of an OT-II transgene-specific ovalbumin-derived peptide were co-transferred into skin-draining lymph nodes. Intravital imaging of OT-II lymphocytes entering these lymph nodes revealed that ICAM-1 and −2 deficient migratory DCs formed fewer stable conjugates with OT-II lymphocytes but promoted normal T cell proliferation. DC ICAMs were also not required for unstable TCR-dependent lymphocyte arrests on antigen presenting migratory DCs. Thus, rare antigen-stimulated ICAM-stabilized T-DC conjugates are dispensable for CD4 lymphocyte proliferation inside lymph nodes.
- 1 January 2019
- Published by Taylor & Francis in Cell Adhesion & Migration
- Vol. 13 (1) , 314-320
Open AccessStable contacts of naïve CD4 T cells with migratory dendritic cells are ICAM-1-dependent but dispensable for proliferation in vivo
It is unclear if naïve T cells require dendritic cell ICAMs to proliferate inside lymph nodes. To check if and when CD4 lymphocytes use ICAMs on migratory DCs, wild-type and ICAM-1 and 2 double knock out bone marrow-derived DCs pulsed with saturating levels of an OT-II transgene-specific ovalbumin-derived peptide were co-transferred into skin-draining lymph nodes. Intravital imaging of OT-II lymphocytes entering these lymph nodes revealed that ICAM-1 and −2 deficient migratory DCs formed fewer stable conjugates with OT-II lymphocytes but promoted normal T cell proliferation. DC ICAMs were also not required for unstable TCR-dependent lymphocyte arrests on antigen presenting migratory DCs. Thus, rare antigen-stimulated ICAM-stabilized T-DC conjugates are dispensable for CD4 lymphocyte proliferation inside lymph nodes.