Edson Mongo

Patients with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), often present with severe leucocytosis and thrombocytopenia, which may lead to symptoms that require prompt diagnosis and treatment. Immunophenotyping combined with cytomorphology is a valuable tool for identifying APL patients. We describe the case of a 9-year-old male patient who was diagnosed with APL in July 2022 using immunophenotyping combined with cytomorphology. The patient was treated with chemotherapy and is now in full remission in the maintenance phase. This case demonstrated the importance of timely differential diagnosis using the correct tools, allowing inclusion in the appropriate treatment protocol.

Aflatoxins gained increased recognition in Mozambique due to their negative impact on health, food security, and trade. Most contamination occurs in peanuts, maize, and their products. Nevertheless, there is little awareness, probably because the press and mass media do not disseminate enough information. This study analyzed the quantity and quality of information on aflatoxins in Mozambique’s leading online newspapers between 2009 and 2018. After analyzing articles using Atlas.ti, the information was synthesized and compared to scholarly sources. Mozambique requires more press and media coverage of aflatoxin research and development activities. Awareness campaigns should be reinforced, distribute information to multiple organizations, and use multiple means, including online mainstream press, spreading information to reach a broad range of people, given the diversity of cultures and villages’ remoteness. Organizations providing information, including universities, need to translate the highly technical information published in scientific journals to help reporters understand the research’s implications. Furthermore, there is a need to identify groups that do not receive messages from current campaigns and appropriate methods for reaching those populations.

Introduction: Rotavirus A (RVA) is a leading cause of acute infant gastroenteritis in Mozambique, responsible for approximately 13,000 annual infant deaths in peri-urban and other areas. Aim: the present review aimed summarize the most relevant and recent literature regarding RVA infection in Mozambique. Methods: the documents were obtained from electronic databases such as PubMed, Google Scholar, Scinapse, Scilit, and Microsoft Academic to find the leading scientific publications related to Mozambique's RVA.Findings: The search allowed us to find 20 peer-reviewed journal articles, three official reports, eight abstracts from national conferences, one thesis, and other documents to supplement the information. Rotavirus frequency ranged between 24 to 42.4%, 34.8% attributable to Mozambique. Most data are hospital-based from Maputo, Sofala, Zambézia, and Nampula provinces. Nampula province shows the highest number of cases. Thus, there might be some bias on the geographical distribution of the virus. The prevalence is high in children less than one year. Regarding the control, the Expanded Program on Immunization (EPI) introduced a monovalent vaccine in September 2015 (Rotarix), which positively impacted the reduction of RVA cases. After vaccine introduction, a high diversity of RVA genotypes was observed, with the predominance of G1P[8] and the emergence of G9P[4], G9P[6], G3P[4]. However, only the whole genome sequence can confirm if it is due to the natural genotypes fluctuation. RVA infection was detected in swine, and a recent analysis reported an RVA strain from children clustered with different animal strains.Conclusion: The scarce yet highly reliable research resources allowed scientists to detect RVA G1P[8] and other genotypes, potential animal reservoirs, and to find that RVA is more prevalent during the transition dry-rainy season, and the virus becomes more frequent when children approach the 11th month, to then decline as they age. It is essential to develop studies providing a broad view of RVA reservoirs as part of the strategy to control its dissemination.Keywords: Rotavirus infections; Children; Diarrhea; Mozambique

Idai was a strong tropical cyclone in Central Mozambique, causing over 1000 deaths, destroying schools, hospitals, roads, and more than 239,731 houses, displacing thousands of people to 136 accommodation sites, and leaving people in need for assistance. The resulting precarious hygienic conditions caused outbreaks of diseases such as malaria and cholera. This communication summarizes the onset of cholera outbreak in Sofala province and its response. It was declared on 27 March, and the number of cases raised up to 6766 and 8 confirmed deaths, with the highest incidence in the city of Beira. The government and partners made integrated efforts to control the disease, establishing treatment centers and units and improving sanitation and hygiene and surveillance. Furthermore, 800,000 people were immunized, and the results seemed satisfactory considering the response. Although cyclones are rare, Mozambique has a very limited capacity to handle their impact, and this urges the country to keep a contingency fund for future disasters.

Cyclone Kenneth was the strongest in the recorded history of the African continent. It landed in the Cabo Delgado province in northern Mozambique on 25 April 2019, causing 45 deaths, destroying approximately 40,000 houses, and leaving 374,000 people in need for assistance, most at risk of acquiring waterborne diseases such as cholera. This short article aims to explain how the resulting cholera outbreak occurred and the response by the government and partner organizations. The outbreak was declared on 2 May 2019, after 14 cases were recorded in Pemba city (11 cases) and the Mecúfi district (3 cases). The disease spread to Metuge, and by the 12th of May 2019, there were 149 cases. Aware of the risk of an outbreak of cholera, the government and partners took immediate action as the cyclone ended, adapting the Cholera Response Plan for Beira, revised after the experience with cyclone Idai (4–21 March 2019). The response relevant to cholera epidemics consisted of social mobilization campaigns for prevention, establishment of treatment centers and units, coordination to improve of water, sanitation and hygiene, and surveillance. By 26 May 2019, 252,448 people were immunized in the area affected by cyclone Kenneth. The recovery process is ongoing but the number of new cases has been reducing, seemingly due to an efficient response, support of several organizations and collaboration of the civil society. Future interventions shall follow the same model of response but the government of Mozambique shall keep a contingency fund to manage disasters such as cyclone Idai and Kenneth. The unlikeliness of two cyclones (Idai and Kenneth) within two months after decades without such kind of phenomena points towards the problem of climate change, and Mozambique needs to prepare effective, proven response plans to combat outbreaks of waterborne diseases due to cyclones.