Lufei Xiao

A novel compound, obtained by one‐step condensation of salicylaldehyde and hydrazine hydrate, has been synthesized, and characterized by various spectroscopic techniques. The crystal structure and photophysical properties of the compound have been analyzed in detail. The compound exhibits distinct aggregation‐induced emission in acetonitrile‐water, and high selectivity towards Cu ²⁺ ions, fast response time, and low detection limit (5.7×10 ⁻⁷ mol/L). In this sense, the compound can be applied as a potential probe for detecting copper (II) ions.

C₁₇H₁₇N₃O₂, monoclinic, P2₁/c (no. 14), a = 10.655(5) Å, b = 5.056(5) Å, c = 28.712 Å, β = 99.034(1)°, V = 1527.6(17) ų, Z = 4, R _gt (F) = 0.0520, wR _ref(F ²) = 0.1611, T = 298(2) K.

A novel compound has been synthesised and characterised by various spectroscopic techniques. Analysing the crystal structures of the compound shows that multiple molecular interactions exist. The compound exhibits distinct aggregation-induced emission activity in EtOH/H2O accompanying a 2-fold enhancement of fluorescence intensity at ~609 nm. In addition, the cytotoxicity assay and confocal microscopy imaging show that the compound is hypotoxic and can be used as a fluorescent labelling dye in the near-infrared region to track mitochondria in living cells.

Detailed information can be gathered using images acquired from multi-scale imaging at the molecular and macroscopic levels. However, the technical difficulties in combining separate functional units and the impermeability to biological barriers remain two of the biggest challenges in the development of such imaging systems. Herein, we report two manganese(II) compounds (MnFM1 and MnFM2) which showed enhanced stable fluorescence including a two-photon signal and magnetic contrast. These metal complexes were rationally constructed using terpyridine-based ligands and manganese(II) ions with small molecular weights. In particular, MnFM1 demonstrated multi-modal imaging effectiveness based on a d⁵ electron configuration: the compound displayed not only good penetration into thick tissue with an enhanced magnetic signal but also the capability of two-photon imaging and stimulated emission depletion (STED) super-resolution imaging. Compared to nano-based cross-platform systems, this candidate might open up the possibility of a revolutionised multi-modal imaging technique using metallic probes.