Kouacou V. Konan
Research Subjects
Kouacou V. Konan has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Eric J. Yager
Trudeau Institute , Saranac Lake, NY 12983
3 shared publications - Jennifer B. Cerone
Division of Neonatology, Department of Pediatrics, Albany Medical College, Albany, NY 12208, USA
1 shared publication - Kentaro Hanada
Center for Quality Management Systems, National Institute of Infectious Diseases
1 shared publication - Margarida Barroso
Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA
1 shared publication - Meredith Monaco-Brown
Department of Pediatrics, Bernard and Millie Duker Children’s Hospital at Albany Medical Center, Albany, NY, United States
1 shared publication - Simon Alem Ogbamikael
Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, 12208-3479, USA
1 shared publication
Latest Publications
- 10 May 2025
- Published by Springer Nature
- p. 1-18
Coronaviruses and Flaviviruses: Replication and Impact on the Innate Immune Response
- 10 May 2025
- Published by Springer Nature
- p. 1-18
Coronaviruses and Flaviviruses: Replication and Impact on the Innate Immune Response
- Open Access
Sphingolipids as Potential Therapeutic Targets against Enveloped Human RNA Viruses
Several notable human diseases are caused by enveloped RNA viruses: Influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain–Barré Syndrome. Being enveloped, the life cycle of this group of viruses is critically dependent on host lipid biosynthesis. Viral binding and entry involve interactions between viral envelope glycoproteins and cellular receptors localized to lipid-rich regions of the plasma membrane. Subsequent infection by these viruses leads to reorganization of cellular membranes and lipid metabolism to support the production of new viral particles. Recent work has focused on defining the involvement of specific lipid classes in the entry, genome replication assembly, and viral particle formation of these viruses in hopes of identifying potential therapeutic targets for the treatment or prevention of disease. In this review, we will highlight the role of host sphingolipids in the lifecycle of several medically important enveloped RNA viruses.
Open AccessSphingolipids as Potential Therapeutic Targets against Enveloped Human RNA Viruses
Several notable human diseases are caused by enveloped RNA viruses: Influenza, AIDS, hepatitis C, dengue hemorrhagic fever, microcephaly, and Guillain–Barré Syndrome. Being enveloped, the life cycle of this group of viruses is critically dependent on host lipid biosynthesis. Viral binding and entry involve interactions between viral envelope glycoproteins and cellular receptors localized to lipid-rich regions of the plasma membrane. Subsequent infection by these viruses leads to reorganization of cellular membranes and lipid metabolism to support the production of new viral particles. Recent work has focused on defining the involvement of specific lipid classes in the entry, genome replication assembly, and viral particle formation of these viruses in hopes of identifying potential therapeutic targets for the treatment or prevention of disease. In this review, we will highlight the role of host sphingolipids in the lifecycle of several medically important enveloped RNA viruses.