Shouchao Wei
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Shouchao Wei has a total of 14 co-authors. Here are the top co-authors by number of shared publications:
- Bin Zhao
Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, 57 South Renmin Road, Zhanjiang, 524001, China.
1 shared publication Chenyao Kang
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
1 shared publicationHaihong Zhou
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
1 shared publicationKanglan Li
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
1 shared publicationLi Hu
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
1 shared publicationRuikai Li
Department of Neurology, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Institute of Neurology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China
1 shared publication
Latest Publications
- 29 October 2019
- Published by Wiley in Journal of Cellular Physiology
- Vol. 235 (5) , 4843-4855
Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well‐known to be involved in the pathological process of Alzheimer's disease (AD). However, the mechanism of OMVs is not clear. In the present study, we demonstrated the involvement of OMVs in the development of cognitive (learning and memory) dysfunction induced by blood–brain barrier (BBB) disruption. More important, further study showed that OMVs induced tau phosphorylation by activating glycogen synthase kinase 3β (GSK‐3β) in the hippocampus. OMVs activated astrocytes and microglia, increased secretion of inflammatory cytokines (nuclear factor κB, interleukin‐1β, and tumour necrosis factor‐α) in the hippocampus. Therefore, OMVs increase the permeability of the BBB and promote the activation of astrocytes and microglia, inducing an inflammatory response and tau hyperphosphorylation by activating the GSK‐3β pathway and finally leading to cognitive impairment.
- 29 October 2019
- Published by Wiley in Journal of Cellular Physiology
- Vol. 235 (5) , 4843-4855
Outer membrane vesicles enhance tau phosphorylation and contribute to cognitive impairment
Outer membrane vesicles (OMVs) are nanosized vesicles produced by the gut microbiota (GM). The GM is well‐known to be involved in the pathological process of Alzheimer's disease (AD). However, the mechanism of OMVs is not clear. In the present study, we demonstrated the involvement of OMVs in the development of cognitive (learning and memory) dysfunction induced by blood–brain barrier (BBB) disruption. More important, further study showed that OMVs induced tau phosphorylation by activating glycogen synthase kinase 3β (GSK‐3β) in the hippocampus. OMVs activated astrocytes and microglia, increased secretion of inflammatory cytokines (nuclear factor κB, interleukin‐1β, and tumour necrosis factor‐α) in the hippocampus. Therefore, OMVs increase the permeability of the BBB and promote the activation of astrocytes and microglia, inducing an inflammatory response and tau hyperphosphorylation by activating the GSK‐3β pathway and finally leading to cognitive impairment.