E. I. Skliarova
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
E. I. Skliarova has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Tatyana Nikolaevna Popova
Department of Medical Biochemistry, Molecular and Cell Biology, Voronezh State University, Universitetskaya Sq. 1, Voronezh 394018, Russia
2 shared publications A. V. Semenikhina
Voronezh State University, Voronezh, Russia
1 shared publicationD. V. Kryl’skii
Center for High Technology, Scientific Research Institute of Applied Acoustics, Dubna-1, Russia
1 shared publicationK. K. Shul’gin
Voronezh State University, Voronezh, Russia
1 shared publication- Konstantin Konstantinovich Shulgin
Voronezh State University
1 shared publication V. V. Spitsina
Voronezh State University, Voronezh, Russia
1 shared publication
Latest Publications
- 1 June 2016
- Published by Springer Nature in Bulletin of Experimental Biology and Medicine
- Vol. 161 (2) , 261-265
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus
Effects of a synthetic biguanide derivative N-[imino(1-piperidinyl)methyl] guanidine (NIPMG) on free radical homeostasis, aconitase activity, and citrate concentration were studied in the liver and blood serum of rats with type 2 diabetes mellitus. Analysis of biochemiluminescence parameters showed that administration of this agent (10 mg/kg body weight) to animals with diabetes reduced the intensity of free radical processes in study tissues relative to the increased values in untreated diabetic animals. Under these conditions, aconitase activity, a principal target of ROS effects, and citrate level in the liver and blood serum of rats approached the control levels. The results show that NIPMG can positively regulate free radical homeostasis and reduce the intensity of oxidative stress in type 2 diabetes mellitus, which was accompanied by normalization of the studied parameters.
- 1 June 2016
- Published by Springer Nature in Bulletin of Experimental Biology and Medicine
- Vol. 161 (2) , 261-265
Effects of N-[Imino(1-Piperidinyl)Methyl] Guanidine on the Intensity of Free Radical Processes, Aconitase Activity, and Citrate Level in the Tissues of Rats with Experimental Type 2 Diabetes Mellitus
Effects of a synthetic biguanide derivative N-[imino(1-piperidinyl)methyl] guanidine (NIPMG) on free radical homeostasis, aconitase activity, and citrate concentration were studied in the liver and blood serum of rats with type 2 diabetes mellitus. Analysis of biochemiluminescence parameters showed that administration of this agent (10 mg/kg body weight) to animals with diabetes reduced the intensity of free radical processes in study tissues relative to the increased values in untreated diabetic animals. Under these conditions, aconitase activity, a principal target of ROS effects, and citrate level in the liver and blood serum of rats approached the control levels. The results show that NIPMG can positively regulate free radical homeostasis and reduce the intensity of oxidative stress in type 2 diabetes mellitus, which was accompanied by normalization of the studied parameters.