Fatma Ölmez Budak

Lower extremity ischemia-reperfusion (I/R) injury is a significant clinical problem that may lead to systemic biochemical alterations and remote organ dysfunction in addition to local tissue damage following surgical and traumatic events. In the present study, the effects of royal jelly (RJ) administration on some systemic parameters were evaluated in rats subjected to an experimental femoral artery I/R model. Male Wistar albino rats were randomly assigned into three groups (n=6): control, I/R and RJ groups. The I/R model was established by femoral artery ligation for 90 minutes followed by 90 minutes of referfusion. Royal jelly was administered orally at a dose of 100 mg/kg for 7 days prior to the surgical procedure. At the end of the reperfusion period, serum levels of LDH, AST, ALT, Na, K, Cl, urea and creatinine were analyzed. Serum LDH, AST, ALT, Na, K, Cl and urea levels were significantly increased in the I/R group compared with the control group (p

OBJECTIVE: In our study, it was purposed to research the distribution of vitamin D according to age, sex, and seasons of thepatients diagnosed with obesity, cancer, and chronic renal failure who applied to Inonu University Turgut Ozal Medical Centerbetween 2018-2021.MATERIALS AND METHODS: In our descriptive study, vitamin D measurements from 01.01.2018-01.01.2021 users who visitedInonu University Turgut Ozal Medical Center and were diagnosed with obesity, cancer, and chronic renal failure were scanned intheir files and assessed retrospectively. The patients were grouped according to their sex, age, and seasons in which the sampleswere taken. 25(OH)D levels were analyzed by LC-MS/MS method. The patients were classified as deficient, inadequate, andnormal in terms of vitamin D levelRESULTS: Vitamin D deficiency was monitored in 54.9% (n = 981) of 1787 cancer patients admitted to our hospital, 63.3% (n =558) of 882 chronic renal failure patients, and 65.8% (n = 1903) of 2894 obese patients.CONCLUSION: Of the 5563 obesity, cancer, and chronic renal failure patients who applied to our hospital; vitamin D deficiencywas found in 61.9% (n = 3442), vitamin D deficiency was found in 23.1% (n = 1284), while vitamin D level was found to be normalin only 15% (n = 837). In terms of vitamin D deficiency, the highest deficiency was seen in obese patients with a rate

The aim of this study was to investigate the serum levels of the A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) 5 and 8 in patients diagnosed with endometrial cancer. Our study included 41 patients diagnosed with endometrial cancer. The control group consisted of 41 patients diagnosed with benign endometrial pathology. The serum samples were centrifuged and stored at –80 °C. The serum levels of ADAMTS were significantly higher (p<.001), whereas the levels of ADAMTS 8 were significantly lower in patients diagnosed with cancer (p<.001). In addition to the presence of known factors in the aetiology of endometrial cancer, the effect of inflammatory factors and some new proteins has centred on the causes of tumourigenesis in recent years. In this sense, these proteins, called the ADAMTS, are the source of new studies.