Diego Mellado
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Diego Mellado has a total of 72 co-authors. Here are the top co-authors by number of shared publications:
- Rodrigo Salas
School of Biomedical Engineering, Universidad de Valparaíso, Valparaíso, Chile
8 shared publications - Carolina Saavedra
Universidad Tecnica Federico Santa Maria
5 shared publications - Carla Taramasco
Instituto de Tecnología para la Innovación en Salud y Bienestar, Facultad de Ingeniería, Universidad Andrés Bello, Viña del Mar 2520000, Chile
4 shared publications - Steren Chabert
Universidad de Valparaíso
4 shared publications - Alejandro Caroca
Universidad Andres Bello
3 shared publications - David Ruete
Universidad Andres Bello
3 shared publications
Latest Publications
- Open Access
- 11 November 2026
- Published by Springer Nature in BMC Geriatrics
Orthogeriatric admission biomarker profiles across hip fragility fracture phenotypes: a real-world cohort study
- 11 November 2026
- Published by Springer Nature in BMC Geriatrics
Open AccessOrthogeriatric admission biomarker profiles across hip fragility fracture phenotypes: a real-world cohort study
- Open Access
- 10 September 2026
- Published by Springer Nature in BMC Medical Informatics and Decision Making
- Vol. 26 (1) , 345
A framework for extraction of clinical information from radiological mammography reports using large language models and retrieval augmented generation
Extracting structured information from free-text radiology reports is essential for downstream clinical analysis and decision support. In mammography, this
- 10 September 2026
- Published by Springer Nature in BMC Medical Informatics and Decision Making
- Vol. 26 (1) , 345
Open AccessA framework for extraction of clinical information from radiological mammography reports using large language models and retrieval augmented generation
Extracting structured information from free-text radiology reports is essential for downstream clinical analysis and decision support. In mammography, this
- Open Access
Improving Diagnostic Sensitivity in Imbalanced Oral Cancer Image Classification: A Comparative Study of CNN and Transformer Architectures
Background: Class imbalance remains a major limitation in artificial intelligence based oral cancer diagnosis, particularly in small clinical image datasets where malignant lesions are underrepresented. Methods: Using a dataset of 3000 mobile-acquired oral cavity images categorized into four diagnostic classes (healthy, benign, oral potentially malignant disorders, and oral cancer), we systematically evaluated the impact of imbalance mitigation strategies on diagnostic performance. Three backbone architectures, EfficientNet, Vision Transformer, and Swin Transformer, were trained under four conditions: raw imbalanced training, random under-sampling, random over-sampling, and medical-safe data augmentation. Performance was evaluated using stratified five-fold cross-validation, and all reported metrics correspond to the mean performance across the validation folds. Results: In multiclass evaluation, augmentation yielded the strongest overall performance, with EfficientNet achieving the highest macro- score (0.669 ± 0.024) and area under curve (0.881 ± 0.015). Under clinically oriented binary malignant-risk evaluation (high-risk vs. low-risk lesions), sensitivity reached 0.817 ± 0.030 with EfficientNet, while data augmentation maintained competitive malignant-risk detection across the evaluated architectures. In contrast, random undersampling consistently yielded lower descriptive performance across architectures. Conclusions: These findings indicate that augmentation-based imbalance mitigation is associated with improved multiclass and oral cancer specific performance while maintaining competitive overall discrimination. The results provide practical guidance for developing clinically robust artificial intelligence systems for early oral cancer detection in imbalanced real-world datasets.Open AccessImproving Diagnostic Sensitivity in Imbalanced Oral Cancer Image Classification: A Comparative Study of CNN and Transformer Architectures
Background: Class imbalance remains a major limitation in artificial intelligence based oral cancer diagnosis, particularly in small clinical image datasets where malignant lesions are underrepresented. Methods: Using a dataset of 3000 mobile-acquired oral cavity images categorized into four diagnostic classes (healthy, benign, oral potentially malignant disorders, and oral cancer), we systematically evaluated the impact of imbalance mitigation strategies on diagnostic performance. Three backbone architectures, EfficientNet, Vision Transformer, and Swin Transformer, were trained under four conditions: raw imbalanced training, random under-sampling, random over-sampling, and medical-safe data augmentation. Performance was evaluated using stratified five-fold cross-validation, and all reported metrics correspond to the mean performance across the validation folds. Results: In multiclass evaluation, augmentation yielded the strongest overall performance, with EfficientNet achieving the highest macro- score (0.669 ± 0.024) and area under curve (0.881 ± 0.015). Under clinically oriented binary malignant-risk evaluation (high-risk vs. low-risk lesions), sensitivity reached 0.817 ± 0.030 with EfficientNet, while data augmentation maintained competitive malignant-risk detection across the evaluated architectures. In contrast, random undersampling consistently yielded lower descriptive performance across architectures. Conclusions: These findings indicate that augmentation-based imbalance mitigation is associated with improved multiclass and oral cancer specific performance while maintaining competitive overall discrimination. The results provide practical guidance for developing clinically robust artificial intelligence systems for early oral cancer detection in imbalanced real-world datasets. - 1 April 2026
- Published by Springer Nature
- p. 54-68
Synthetic Sales Data Generation for Chilean SMEs Using GANs
- 1 April 2026
- Published by Springer Nature
- p. 54-68
Synthetic Sales Data Generation for Chilean SMEs Using GANs
- 1 April 2026
- Published by Springer Nature
- p. 27-38
Tokenization and Search of Postal Addresses
- 1 April 2026
- Published by Springer Nature
- p. 3-15
Improving Public Sector Efficiency Through Rapid Machine Learning-Based Product Classification
- 1 April 2026
- Published by Springer Nature
- p. 3-15
Improving Public Sector Efficiency Through Rapid Machine Learning-Based Product Classification
- 4 February 2026
- Published by Elsevier in Health Policy and Technology
- Vol. 15 (3)
SITeCard: A human-centric explainable intelligent system to support the cardiovascular rehabilitation process
- 4 February 2026
- Published by Elsevier in Health Policy and Technology
- Vol. 15 (3)
SITeCard: A human-centric explainable intelligent system to support the cardiovascular rehabilitation process
- Open Access
- 26 September 2024
- Published by Springer Nature in Research Square
A Framework for Extraction of Clinical Information from Radiological Mammography Reports Using Large Language Models and Retrieval Augmented Generation.
Background: The application of text mining in radiological reports is crucial for many tasks but principally analyzing and projecting trends to enhance diagnostic accuracy. This is especially important in mammography reports, where early detection is crucial. Large language models (LLMs) provide a viable alternative. They can generate accurate results from a limited set of examples compared with the traditional state-of-the-art models. Methods: This work presents a framework utilizing a general proposed retrieval-augmented generation (RAG) and large language model LLM to create a replicable model capable of structuring mammography radiology reports and extracting relevant concepts associated with the findings. The resulting model is applied to a real-world scenario, using a dataset of mammography radiology reports provided by a hospital. These reports, written by radiologists, are in free text and Spanish. The application of the designed framework is evaluated across several LLMs, and its results are compared to a conventional and specialized NER-type model based on BERT, using a dataset labeled by radiologists. Results: Several models have been implemented and evaluated with the proposed LLM framework. In Named Entity Recognition (NER) tasks using GPT-4, the zero-shot learning scenario achieved an F1-score of 0.80, while the five-shot scenario reached an F1-score of 0.96. This is comparable to the specific-context NER-BERT model, which achieved an F1-score of 0.97. Similarly, in Relation Extraction tasks, we achieved an F1-score of 0.93, a task for which a specialized model was not available. Conclusion: The results demonstrate that large language models (LLMs) can benefit from additional in-prompt examples and achieve results comparable to those of specialized models like NER-BERT. Additionally, this study shows that through a well-defined framework, it is possible to effectively leverage the capabilities of LLMs for specific purposes such as NER and Relation Extraction over clinical text and mammography reports.
- 26 September 2024
- Published by Springer Nature in Research Square
Open AccessA Framework for Extraction of Clinical Information from Radiological Mammography Reports Using Large Language Models and Retrieval Augmented Generation.
Background: The application of text mining in radiological reports is crucial for many tasks but principally analyzing and projecting trends to enhance diagnostic accuracy. This is especially important in mammography reports, where early detection is crucial. Large language models (LLMs) provide a viable alternative. They can generate accurate results from a limited set of examples compared with the traditional state-of-the-art models. Methods: This work presents a framework utilizing a general proposed retrieval-augmented generation (RAG) and large language model LLM to create a replicable model capable of structuring mammography radiology reports and extracting relevant concepts associated with the findings. The resulting model is applied to a real-world scenario, using a dataset of mammography radiology reports provided by a hospital. These reports, written by radiologists, are in free text and Spanish. The application of the designed framework is evaluated across several LLMs, and its results are compared to a conventional and specialized NER-type model based on BERT, using a dataset labeled by radiologists. Results: Several models have been implemented and evaluated with the proposed LLM framework. In Named Entity Recognition (NER) tasks using GPT-4, the zero-shot learning scenario achieved an F1-score of 0.80, while the five-shot scenario reached an F1-score of 0.96. This is comparable to the specific-context NER-BERT model, which achieved an F1-score of 0.97. Similarly, in Relation Extraction tasks, we achieved an F1-score of 0.93, a task for which a specialized model was not available. Conclusion: The results demonstrate that large language models (LLMs) can benefit from additional in-prompt examples and achieve results comparable to those of specialized models like NER-BERT. Additionally, this study shows that through a well-defined framework, it is possible to effectively leverage the capabilities of LLMs for specific purposes such as NER and Relation Extraction over clinical text and mammography reports.
- Open Access
An Assessment of In-the-Wild Datasets for Multimodal Emotion Recognition
Multimodal emotion recognition implies the use of different resources and techniques for identifying and recognizing human emotions. A variety of data sources such as faces, speeches, voices, texts and others have to be processed simultaneously for this recognition task. However, most of the techniques, which are based mainly on Deep Learning, are trained using datasets designed and built in controlled conditions, making their applicability in real contexts with real conditions more difficult. For this reason, the aim of this work is to assess a set of in-the-wild datasets to show their strengths and weaknesses for multimodal emotion recognition. Four in-the-wild datasets are evaluated: AFEW, SFEW, MELD and AffWild2. A multimodal architecture previously designed is used to perform the evaluation and classical metrics such as accuracy and F1-Score are used to measure performance in training and to validate quantitative results. However, strengths and weaknesses of these datasets for various uses indicate that by themselves they are not appropriate for multimodal recognition due to their original purpose, e.g., face or speech recognition. Therefore, we recommend a combination of multiple datasets in order to obtain better results when new samples are being processed and a good balance in the number of samples by class.
Open AccessAn Assessment of In-the-Wild Datasets for Multimodal Emotion Recognition
Multimodal emotion recognition implies the use of different resources and techniques for identifying and recognizing human emotions. A variety of data sources such as faces, speeches, voices, texts and others have to be processed simultaneously for this recognition task. However, most of the techniques, which are based mainly on Deep Learning, are trained using datasets designed and built in controlled conditions, making their applicability in real contexts with real conditions more difficult. For this reason, the aim of this work is to assess a set of in-the-wild datasets to show their strengths and weaknesses for multimodal emotion recognition. Four in-the-wild datasets are evaluated: AFEW, SFEW, MELD and AffWild2. A multimodal architecture previously designed is used to perform the evaluation and classical metrics such as accuracy and F1-Score are used to measure performance in training and to validate quantitative results. However, strengths and weaknesses of these datasets for various uses indicate that by themselves they are not appropriate for multimodal recognition due to their original purpose, e.g., face or speech recognition. Therefore, we recommend a combination of multiple datasets in order to obtain better results when new samples are being processed and a good balance in the number of samples by class.