Alexey Leonidovich Klyuev

Biodegradable magnesium implants offer significant clinical promise, but their safe use requires reliable real-time in vivo monitoring of coating integrity. Existing methods lack sufficient sensitivity and temporal resolution to detect degradation at early stages, and there are no computational tools able to predict the success of a given sensor design before animal experiments. In the present paper, we present BioElectroSynth—a digital simulator of an implantable zero-resistance ammetry (ZRA) corrosion sensor in a mouse model. The simulator combines electrochemical noise, cardiac and muscular bioelectric interference, and instrumental limitations into a unified model, enabling virtual experiments, which mimic the complexity of the in vivo system. Using Monte Carlo analysis, we establish that a 2% breach in a chitosan coating on an AZ91 magnesium alloy electrode is statistically detectable from approximately 30 recordings of 30 s each, and quantify how electrode area, its location, sampling rate, and coating quality jointly determine detection sensitivity. The framework provides the first quantitative tool for predicting in vivo experiment feasibility from standard in vitro electrochemical data alone. By identifying instrument and design configurations that are statistically underpowered before any animal use, the approach directly supports the 3R principles of humane research.

Porous highly cross-linked polymer (PIP) was synthesized by a polycondensation reaction between hexachlorocyclotriphosphazene and piperazine. The obtained polymer has a surface area of 76.9 m²/g and a mesoporous structure. After carbonization, the obtained product (PIP-C) has a surface area of 177 m²/g. The obtained carbon product contained nitrogen and phosphorus heteroatoms, which leads to a higher specific capacitance (155.6 F/g) and catalytical activity in the electroreduction of oxygen (15.9 A/g). This work shows the possibility of the use of such porous phosphazene polymers as precursors for heteroatom-doped carbon materials, which might be used in electrochemical devices like electrodes for supercapacitors or metal-free electrocatalysts in fuel cells.

A comparative study of anticorrosive inhibited polymer films on the tungsten surface formed from an aqueous solution of inhibited formulations (INFOR) containing organosilane and corrosion inhibitors was carried out by means of the prolonged exposure of a tungsten product in a modifying solution and by the method of cataphoretic deposition (CPD). Depending on the method of forming films on tungsten, the molecular organization of the near-surface layers was studied (ATR-FTIR), and the subprimary structure of the films was explored (TEM). The optimal modes of cataphoresis deposition (CPD duration and current density applied to the sample) for the formation of a protective inhibited polymer film on the tungsten surface were established by means of SEM. The energy and thermochemical characteristics (sessile drop and DSC methods), as well as operational (adhesive behavior) and protective filming ability (EIS and corrosion behavior), according to the method of formation of inhibited polymer film, were determined. Based on the combined characteristics of the films obtained by the two methods and the deposition modes, the CPD method showed better performance than the electroless dipping method.

A new redox-active composite material based on reduced graphene oxide (RGO), poly-o-phenylenediamine (PPD), and silicotungstic acid (SiW) is studied. The SEM data showed an abrupt decrease in the content of oxygen atoms in the composite as compared to pure graphene oxide (GO). This is associated with its reduction to RGO in the course of RGO–PPD–SiW synthesis. A combination of RGO conductivity and redox catalysis due to the electroactive components (PPD and SiW) enables one to develop various sensors by applying RGO–PPD–SiW onto planar electrodes (screen-printed carbon electrodes, SPCE). In this work, the possibility of developing a sensor for the content of antituberculous antibiotic isoniazid (isonicotinic acid hydrazide C₆H₇N₃O, INAH) is studied. Using the CVA method, it is shown that the concentration dependence of isoniazid oxidation current is linear. The electrocatalytic behavior of the composite during the isoniazid oxidation is also supported by the impedance spectroscopy.

INTRODUCTION: Medical staff limits often the presence of parents in ICU with their children, citing the fact that parents can bring serious difficulties to the work of the department. OBJECTIVE: To evaluate social and psycho-emotional aspects of joint stay of a family member (parents) with a patient (child) in ICU from the viewpoint of the medical stuff. MATERIALS AND METHODS: The study included hospitals, which followed the principles of a family centered care (FCC) approach in the treatment of patients (median and quartiles years — 4.00 (2.00; 10.00)). The 417 questionnaires were analyzed. The data were subjected to descriptive analysis. RESULTS: Respondents assessed the working conditions and the level of their wages not higher than satisfactory in more than 30 % of the answers. In the spectrum of assistance provided by family members to a patient in the ICU, the medical staff indicated 89 % and 91.5 % respectively sanitary and hygienic care, 82 % and 81.9 % — feeding him, 32 % and 47.1 % — assistance in transportation patient. The first level of preparation of parents for caring for a patient in the ICU was 3 (2; 3) — doctors and 3 (2; 3) — nurses, and when the patient was transferred from the ICU — 4 (3; 4) and 3 (3; 4) respectively. Claims in the opinion of the medical staff from patients and parents were due to their underestimation of the complexity of the situation with the patient (58 % and 48.6 %), the characteristics of patients (33 % and 36.3 %) and their parents (48 % and 39.8 %), insufficient awareness of the patientʼs health status (nurses — 23.2 %). CONCLUSIONS: The FCC in the ICU does not introduce significant psycho-emotional and labor loads in the professional activities of medical staff and creates positive conditions for increasing the level of knowledge and skills of parents in caring for their children.

INTRODUCTION. The problem of parents and children staying together in intensive care units (ICU) is solved from a categorical ban in the past, to exceptional loyalty at the present time, when it is allowed to stay with the patient of his beloved pets. OBJECTIVES. To study the social and psycho-emotional aspects of the joint stay of parents with a child in the intensive care unit as an indicator of satisfaction with the medical care. MATERIALS AND METHODS. Hospitals with a commitment to a family centered care (FCC) were included in the study. Data collection was carried out on the basis of questionnaires (n = 471), when filling out which the respondent had to choose one of the submitted answers with a score from 1 to 5 (the highest), or in some cases submit their own version. The data were analyses by descriptive. RESULTS. Respondents rated 4 (4–5) the conditions of stay in the ICU, concerning: its location in a medical institution; the purpose of the premises of the department and the quality of their sanitary and hygienic cleaning; diagnostics, treatment, care; communication and psycho-emotional support by medical staff. The nature of the assistance provided by family members to the patient: sanitary and hygienic care (87.9 %), feeding (86.4 %), monitoring of medical equipment (50.9 %), assistance to medical staff in transporting the patient (53.5 %). The level of training of parents in caring for a child in the ICU upon admission is 3 (3–4), and upon transfer from the department 4 (4–4). CONCLUSIONS. The joint stay of parents with children in the ICU does not bring a negative psycho-emotional burden for them in communicating with medical staff, allows parents to obtain and improve their knowledge and skills in child care, to provide assistance in this. The problem of FCC requires further study.

The electrochemical behavior of electroactive composites based on reduced graphene oxide (RGO), poly‐o‐phenylenediamine (PPD) and heteropolyacids (HPA) (silicotungstic [SiW] and phosphotungstic [PW]) was comparatively studied by means of cyclic voltammetry (CVA), charge–discharge galvanostatic curves, and electrochemical impedance. The composites were applied to planar screen‐printed carbon electrodes as the first step to creating various devices, in particular, sensors based on novel composites. Like RGO‐PPD‐SiW composites, RGO‐PPD‐PW composites also exhibit several redox transitions. With respect to the method of synthesis (order of applying components), RGO‐PPD‐PW can exhibit the properties of a mediator catalyst as was demonstrated for example of the redox transition in the quinone‐hydroquinone couple, where reversibility is significantly enhanced by conducting the reaction on a RGO‐PPD‐PW‐modified electrode.

The technique of Chebyshev polynomials of discrete variable is used to analyze a random time series. The main result of the work is a new theoretical relationship between the structure function and the discrete Chebyshev spectrum. The relationship is used for the trend-resistant structural analysis of electrochemical noise of corrosion process and for the trend-resistant structural analysis of electronic noise of measuring instrument. Not only the structure function of the analyzed random series, but also the structure function of trend is estimated. The theoretical relationship between the structure function and the discrete Chebyshev spectrum can be used for the trend-resistant structural analysis of random time series of any nature.