Maria Del Carmen Diaz de la Loza
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Maria Del Carmen Diaz de la Loza has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Ahmed Elbediwy
Department of Biomolecular Sciences, Kingston University London, Kingston-upon-Thames KT1 2EE, UK
1 shared publication - Francesca E. Mackenzie
Department of Chemical and Pharmaceutical Sciences, Kingston University London
1 shared publication - Lucrezia Bruno
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK
1 shared publication - Mathias Cobbaut
Francis Crick Institute, London NW1 1AT, UK
1 shared publication - Michael Stolinski
Department of Biomolecular Sciences, Kingston University London, Kingston-upon-Thames KT1 2EE, UK
1 shared publication - Simge Karagil
Department of Biomolecular Sciences, Kingston University London, Kingston-upon-Thames KT1 2EE, UK
1 shared publication
Latest Publications
- Open Access
Dysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.
Open AccessDysfunctional Mechanotransduction through the YAP/TAZ/Hippo Pathway as a Feature of Chronic Disease
In order to ascertain their external environment, cells and tissues have the capability to sense and process a variety of stresses, including stretching and compression forces. These mechanical forces, as experienced by cells and tissues, are then converted into biochemical signals within the cell, leading to a number of cellular mechanisms being activated, including proliferation, differentiation and migration. If the conversion of mechanical cues into biochemical signals is perturbed in any way, then this can be potentially implicated in chronic disease development and processes such as neurological disorders, cancer and obesity. This review will focus on how the interplay between mechanotransduction, cellular structure, metabolism and signalling cascades led by the Hippo-YAP/TAZ axis can lead to a number of chronic diseases and suggest how we can target various pathways in order to design therapeutic targets for these debilitating diseases and conditions.