Hristo Todorov
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Hristo Todorov has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Konstantin Radyushkin
TARCforce3R Center, University Medical Center of the Johannes Gutenberg University, 55122 Mainz, Germany
1 shared publication - Marlon Wendelmuth
Institute for Human Genetics, University Medical Center, Mainz
1 shared publication - Michael Willam
Leibniz Institute for Resilience Research, Mainz
1 shared publication - Susann Schweiger
Institute of Human Genetics, University Medical Center Mainz, Mainz
1 shared publication - Susanne Gerber
Institute of Human Genetics, University Medical Center Mainz, Mainz, Germany
1 shared publication
Latest Publications
- Open Access
- 17 January 2020
- Published by Cold Spring Harbor Laboratory in bioRxiv
Dynamic longitudinal behavior in animals exposed to chronic social defeat stress
Chronic social defeat (CSD) can lead to impairments in social interaction and other behaviors that are supposed to model features of major depressive disorder (MDD). Not all animals subjected to CSD, however, develop these impairments, and maintained social interaction in some animals is widely used as a model for resilience to stress-induced mental dysfunctions. So far, animals have mainly been studied shortly (24 hours and 7 days) after CSD exposure and longitudinal development of behavioral phenotypes in individual animals has been mostly neglected. We have analyzed social interaction and novel object recognition behavior of stressed mice at different time points after CSD and have found very dynamic courses of behavior of individual animals. Instead of the two groups, resilient or susceptible, that are found at early time points our data suggest four groups with (i, ii) animals behaving resilient or susceptible at early and late time points, respectively (iii) animals that start susceptible and recover with time or (iv) animals that are resilient at early time points but develop vulnerability later on.
- 17 January 2020
- Published by Cold Spring Harbor Laboratory in bioRxiv
Open AccessDynamic longitudinal behavior in animals exposed to chronic social defeat stress
Chronic social defeat (CSD) can lead to impairments in social interaction and other behaviors that are supposed to model features of major depressive disorder (MDD). Not all animals subjected to CSD, however, develop these impairments, and maintained social interaction in some animals is widely used as a model for resilience to stress-induced mental dysfunctions. So far, animals have mainly been studied shortly (24 hours and 7 days) after CSD exposure and longitudinal development of behavioral phenotypes in individual animals has been mostly neglected. We have analyzed social interaction and novel object recognition behavior of stressed mice at different time points after CSD and have found very dynamic courses of behavior of individual animals. Instead of the two groups, resilient or susceptible, that are found at early time points our data suggest four groups with (i, ii) animals behaving resilient or susceptible at early and late time points, respectively (iii) animals that start susceptible and recover with time or (iv) animals that are resilient at early time points but develop vulnerability later on.