Wei Wang

Background: The association between type 2 diabetes mellitus (T2DM) and mortality in patients with liver cirrhosis remains controversial. This study aimed to evaluate whether a history of T2DM influences short-term all-cause mortality in hospitalized patients with decompensated liver cirrhosis (DLC). Methods: We conducted a retrospective study of hospitalized patients with DLC at three medical centers in China between November 2019 and June 2024. The study endpoint was the 6-month mortality. The association between T2DM and mortality was assessed using multivariable logistic regression, and stabilized inverse probability of treatment weighting (sIPTW) analysis was applied for sensitivity analysis. Results: Among 984 eligible patients, 239 (24.3%) had a history of T2DM. Patients with T2DM were older and had a higher prevalence of hypertension and coronary artery disease; however, no significant difference in 6-month mortality was observed between patients with and without T2DM. Multivariable logistic regression showed no independent association between a history of T2DM and mortality (OR = 0.80, 95% CI: 0.51–1.23), this result remained consistent using sIPTW analysis (OR = 0.78, 95% CI: 0.51–1.21). Conclusions: A history of T2DM may not be independently associated with short-term mortality in patients with DLC. These findings suggest that T2DM status may not be prioritized over liver-specific prognostic factors when assessing the short-term mortality risk in patients with DLC.

Background/Aims: Type 2 diabetes mellitus (T2DM) is increasingly recognized as a factor that may influence the course of acute pancreatitis (AP), but its independent associations with severity and mortality remain uncertain. The study investigated the independent association of preexisting T2DM with disease severity and in-hospital mortality in individuals with AP. Materials and Methods: This multicenter retrospective cohort study included 4458 patients with AP from 3 medical centers. Patients were categorized into T2DM (n = 711) and non-T2DM groups (n = 3747). Demographic and clinical data were collected. Multivariable logistic regression analysis was used to evaluate the associations of T2DM with disease severity and in-hospital mortality after adjustment for potential confounders. Stabilized inverse probability of treatment weighting (sIPTW) analyses were performed to assess the robustness of the results. Results: Compared with the non-T2DM group, the T2DM group was older and had a significantly higher proportion of males, and higher prevalences of hypertension and chronic kidney disease. In multivariable analysis, T2DM was independently associated with increased disease severity (OR = 1.42, 95% CI: 1.19-1.69) but not with in-hospital mortality (OR = 1.14, 95% CI: 0.61-2.02). The sIPTW analysis yielded consistent findings, with T2DM remaining independently associated with increased disease severity but not with in-hospital mortality. Conclusion: Preexisting T2DM is independently associated with increased disease severity in patients with AP but not with in-hospital mortality. Cite this article as: Wu B, Ju H, He C, Wang W, Wang G. Type 2 diabetes increases severity but not mortality in acute pancreatitis: A large multicenter analysis. Turk J Gastroenterol. Published online September 07, 2026. doi: 10.5152/tjg.2026.26159.

Background: 4-Methylbenzylidene camphor (4-MBC) is extensively utilized as an ultraviolet (UV) filter in sunscreens due to its ability to block harmful UV radiation. However, growing concerns exist regarding its environmental persistence and bioaccumulative potential, which may pose significant risks to human health. This study aims to systematically investigate the environmental and health impacts of 4‑MBC, with a focus on its potential roles in carcinogenesis and neurodegenerative diseases. This study aims to systematically investigate the environmental and health impacts of 4-MBC, with a focus on its potential roles in carcinogenesis and neurodegenerative diseases. Results: Using network toxicology and molecular docking approaches, we explored the interactions between 4‑MBC and key molecular targets relevant to these diseases, specifically AKT1, ESR1, HDAC1, and MYC. Our results indicate that 4‑MBC may disrupt biological pathways involved in cell proliferation and apoptosis, thereby interfering with cellular mechanisms underlying cancer progression and the onset of neurodegenerative conditions. Conclusions: This study suggests that 4‑MBC represents a notable environmental health risk, underscoring the need to update current regulations and public health policies to mitigate its impacts. These findings advocate for further research into safer UV filters and highlight the importance of monitoring and managing environmental contaminants that compromise human health.

Research exploring the relationship between atrial fibrillation (AF) and acute pancreatitis (AP) is limited. This study aims to explore the association bet

The derived monocyte to lymphocyte ratio (dMLR) serves as an indicator of the overall systemic inflammatory and immune status. This study seeks to investigate the correlation between dMLR and 90-day mortality in patients diagnosed with decompensated liver cirrhosis (DLC). A total of 1,342 eligible patients from three medical centres were included in this study. Multivariable Firth-corrected logistic regression analysis was conducted to explore the independent association between dMLR and 90-day mortality. Additionally, restricted cubic spline (RCS) analysis was employed to examine the relationship between dMLR and mortality risk. These findings were subsequently validated in two independent cohorts. In the total cohort, the prognostic accuracy of dMLR for predicting outcomes in DLC patients was evaluated through receiver operating characteristic (ROC) curve analysis. In the initial cohort, the observed 90-day mortality rate was 12.5%. ROC analysis showed that dMLR had comparable predictive ability to the Model for End-Stage Liver Disease. The multivariable Firth-corrected logistic regression analysis revealed that dMLR is an independent predictor of 90-day mortality. Furthermore, RCS analysis demonstrated that an increase in dMLR values corresponded with an elevated risk of mortality. These findings were corroborated in two validation cohorts. The dMLR is independently associated with 90-day mortality in patients with DLC, with an increasing risk of death corresponding to higher dMLR values. dMLR may function as a simple, cost-effective, and reliable biomarker, assisting clinicians in identifying high-risk patients and may guide risk stratification and management.

Malignant anorectal melanoma (AM) is a rare tumor characterized by its aggressive behavior. To date, there has been no comprehensive investigation into the association between the log odds of positive lymph nodes (LODDS) and the prognosis of patients with malignant AM who have undergone surgical intervention. Data were extracted from the Surveillance, Epidemiology and End Results (SEER) database for patients diagnosed with primary malignant AM who have undergone surgical intervention between 2000 and 2021. The Kaplan-Meier (KM) method with the log-rank test was used to compare survival curves between different LODDS groups. Multivariate Cox models were employed to evaluate the independent association between LODDS and overall survival (OS). An analysis to explore the potential influence of unmeasured confounders on the relationship between LODDS and OS was conducted using the E value. The study included a total of 126 eligible patients. KM analysis revealed that patients with low LODDS exhibited significantly improved OS compared to those with high LODDS (p < 0.001). The multivariate Cox analysis demonstrated that LODDS was independently associated with OS. The calculated E value suggested that the potential impact of unmeasured confounders on the association between LODDS and OS was likely minimal. The findings indicate that LODDS is independently associated with the prognosis of patients with AM undergoing surgical intervention. These results may enhance clinicians' understanding of the prognosis of this rare malignancy and provide a basis for guiding therapeutic decisions.

Background: The impact of prolonged surgical waiting time (SWT) on the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains controversial. This study aimed to explore the impact of prolonged SWT on PDAC-specific mortality (PSM). Methods: The data of patients with stage I–II primary PDAC who received radical resection were obtained from the Surveillance, Epidemiology, and End Results database. The trends analysis was performed to explore the association between the year of diagnosis and SWT. The Fine-Gray multivariate competing risk analysis was performed to determine the impact of prolonged SWT on PSM. Results: A total of 8,562 patients were included in this study. In general, SWT had an increasing trend from 2007 to 2017. Multivariate survival analysis showed that SWT of ≥1 month and Conclusions: We found that prolonged SWT does not affect or worsen PSM of patients with stage I–II PDAC who underwent successful radical resection. Our findings offer useful evidence about the association between prolonged SWT and PSM, which may relieve patients’ and doctors’ psychological stress related to delayed surgery to some extent.

The process of biological aging in patients diagnosed with chronic liver disease remains unclear. The current study aims to investigate if there is an accelerated biological aging process in participants with advanced fibrosis (AF) and metabolic dysfunction-associated steatotic liver disease (MASLD). Data from the 2017–2018 NHANES cycle were analyzed. AF was determined based on the values of liver stiffness measurement (LSM) and MASLD was defined according to new consensus nomenclature. Klemera-Doubal method biological age (KDM bioage) and Phenotypic age (Phenoage) were adopted to quantify biological age. Phenoage advancement (Phenoage_advance) and KDM advancement (KDM_advance) were generated as the difference between the calculated biological age and chronological age, and a positive residual was regarded as an indicator of accelerated biological aging. A total of 3974 participants was enrolled. The weight mean KDM_advance and phenoage_advance in AF group was 4.22 years (95%CI: 2.96–5.49 years) and 2.61 years (95%CI: 1.80–3.41 years), while in MASLD group was 0.37 years (95%CI: -0.28–1.03 years) and 0.04 years (95%CI: -0.64–0.72 years), respectively. Multivariate linear regression analysis showed that participants with AF had older KDM_advance and phenoage_advance compared with those without AF (1.50 years (95%CI: 0.23–2.77 years), P = 0.02; 1.00 years (95%CI: 0.18–1.82 years), P = 0.02; respectively), in models adjusting demographic characteristics, socioeconomic status, lifestyle factors, and comorbidities. No significant association was found between MASLD and KDM_advance and phenoage_advance. AF, not MASLD, was independently associated with accelerated biological aging in adults from a US representative sample.

The serum albumin-to-serum creatinine ratio (sACR) is independently associated with the prognosis of multiple diseases. However, its relationship with in-hospital mortality of patients with severe acute pancreatitis (SAP) remains unclear. Patients diagnosed with SAP between April 2016 and December 2023 were collected. These patients were categorized into low and high sACR groups based on an optimal cut-off value calculated using Youden’s index. Multivariate logistic regression analysis was utilized to examine the relationship between sACR levels and the in-hospital mortality. Additionally, a limited restricted cubic spline (RCS) method was employed to evaluate the nonlinear relationship between sACR values and the risk of in-hospital mortality. The potential for unmeasured confounders between sACR levels and in-hospital mortality was also explored through the calculation of the E value. A total of 114 eligible patients were included in this sutdy. The multivariate logistic regression analysis indicated an independent association between sACR levels and in-hospital mortality (p < 0.001). The RCS analysis demonstrated a linear correlation between sACR values and the risk of in-hospital mortality (P for non-linearity > 0.05), where the risk increased as the sACR value decreased. The research findings suggest that sACR levels are independently associated with in-hospital mortality of patients with SAP, providing a means for early identification of those at high risk of in-hospital mortality. This early identification may facilitate the optimizing and strengthening of treatments, ultimately leading to improved outcomes.