Chongqi Jia

Purpose To investigate the effect of baseline lung function on the trajectory of frailty over time. Methods This longitudinal study included 3,658 adults aged 60 and over (average age 70.4 years old and 46.4% males) at baseline from the English Longitudinal Study of Ageing. Lung function indicators included forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1), both measured at baseline examination. Frailty was defined based on Fried’s frailty phenotype criteria, the measurement was repeated for four times. Linear mixed-effect regression model was applied to estimate the association of baseline lung function with the trajectory of frailty over time. Results Frailty score increased significantly over time (β = 0.030, P < 0.001). Linear mixed-effect regression model identified significant interactions between FVC (β =− 0.018, P < 0.001) or FEV1 (β =− 0.022, P < 0.001) and time on frailty. Conclusion Poor baseline lung function might accelerate the speed of frailty. Lung function might be an important predictor of the development and progression of frailty among older adults.

Single measurements of waist circumference (WC) can predict the incident hypertension, while dynamic change patterns of WC during young adulthood and their association with the incidence of hypertension are poorly demonstrated. This study aimed to identify the longitudinal WC trajectories during young adulthood and explore their association with the risk of incident hypertension. We utilized the data from the China Health and Nutrition Survey (1993–2015) and included 6604 participants aged 18–50 years with repeated WC measurements of 3–8 times and information on incident hypertension. The group-based trajectory model was used to identify WC trajectories. Cox proportional hazard model was conducted to evaluate the association of WC trajectories with the risk of incident hypertension. We identified four distinct WC trajectories during young adulthood. Participants with the low-increasing and the moderate-increasing trajectories had increasing but normal WC, while those with the high-increasing and the sharp-increasing trajectories developed from non-abdominal obesity to abdominal obesity. Compared with the low-increasing trajectory, the adjusted hazard ratios (95% confidence intervals) were 1.48 (1.16–1.89), 2.50 (1.84–3.40), and 3.86 (2.40–6.21) for the moderate-increasing, the high-increasing, and the sharp-increasing trajectories, respectively. After further excluding participants with obesity at baseline, this association did not alter substantially. The gender-specific trajectory analyses yielded similar results. WC trajectories during young adulthood were significantly associated with the risk of incident hypertension in Chinese. Moreover, even the increasing WC trajectory within the normal range during young adulthood might increase the risk of hypertension.

Objectives: The present study aimed to explore the interaction between grip strength and physical activity on depression, and investigate the association of physical activity with the change in depression by different grip strength groups among middle-aged and older European adults.Methods: A total of 13936 participants aged 50 years or older from the Survey of Health, Ageing and Retirement in Europe 2007-2017 were included in this study. Group-based trajectory modeling was used to identify the low, middle and high group of grip strength by gender. Generalized estimated equations were fitted to analyze the interaction effect.Results: Significant interactions between grip strength group and physical inactivity were found (O _interaction=16.70, pinteraction=22.15, pinteraction=22.85, pinteraction=3.20, p=0.526). Participants in the physical inactivity group had higher depression scores in the low and moderate grip strength group.Conclusions: Grip strength and physical inactivity have interaction with depression. Lower grip strength and insufficient physical activity could increase depressive symptoms. People with lower grip strength and physical inactivity should pay special attention to the prevention of depression.

Objective: This study aimed to assess the relationship between waist-to-height (WHtR) and estimated glomerular filtration rate (eGFR) in men, non-menopausal, and postmenopausal women among middle-aged and elderly Chinese. Methods: This study analyzed the data of 7,807 participants in a cross-sectional survey, ie, the third wave of the China Health and Retirement Longitudinal Study. Restrictive cubic-spline regression with three knots was used to assess the dose–response association of WHtR with eGFR. Piecewise linear regression models were further established to calculate the slope of each segment and their 95% confidence interval (CI). Results: After adjusting for potential confounders, an inverse L-shaped dose–response relationship was found between WHtR and eGFR among men (P _nonlinear = 0.024, threshold = 0.513) and postmenopausal women (P _nonlinear = 0.009, threshold = 0.503). The slopes on the right sides of the threshold were statistically significant among men (β ₂ = −33.77, 95% CI: −53.23 to −14.31) and postmenopausal women (β ₂ = −36.53, 95% CI: −49.71 to −23.35), respectively. A weak negative linear relationship existed between WHtR and eGFR in non-menopausal women. Conclusions: The relationship between WHtR and eGFR tended to be inverse-L-shaped in men and postmenopausal women, but may vary with postmenopausal status in women.

The aim was to investigate whether serum uric acid (SUA) was associated with incident hypercholesterolaemia and hypertriglyceridaemia in middle-aged and older Chinese. This prospective cohort study...

Objective: The aim of this study was to assess the association of early menopause with diabetes and the mediating effect of abdominal obesity. Methods: This cross-sectional study was conducted among 5,693 participants. The data from the second follow-up (2015) of the China Health and Retirement Longitudinal Study were used. Participants self-reported their age at menopause and were divided into three age groups (54 years) according to the 10th, 10th to 90th, and 90th percentiles, with a menopausal age of 45 to 54 years serving as reference. The total effect was decomposed into direct and indirect (mediating) effects using logistic regression based on the Karlson-Holm-Breen method. Results: Compared to the menopausal age of 45 to 54 years, early menopause (P = 0.321) for abdominal obesity. Conclusions: Early menopause may be associated with diabetes among Chinese women. Moreover, the mediating effect of abdominal obesity makes up a small percentage and has no statistical significance. Further studies are needed to examine other mechanisms behind the association of early menopause with diabetes.

ObjectiveFor assessing the nonlinearity and delayed effect of temperature on incidence of Tuberculosis (TB) and effect modification by meteorology factors, daily data on meteorological factors, air pollutants and incidence were obtained in Jinan, China, from 2012 to 2015.MethodsA distributed lag non-linear model (DLNM) combined with quasi-Poisson regression model was employed to assess the nonlinearity and the delayed effect of associations. We further built a series of weather-stratified models categorizing the meteorology factors into two levels to assess the effect modification of the ambient temperature effect. ResultsThe correlation between tuberculosis (TB) cases and daily average temperature (T_mean) was nonlinear with a delayed effect. At the current day (lag 0), the increase of T_mean decreased the risk of TB incidence; over lag 0-70 days, the decrease of low T_mean and the increase of the high T_mean both indicated the increased risk of TB. The cold temperature showed an immediate effect at the current day, with a harvesting effect in the following days. There was no significant harvesting effect in hot effect. Meanwhile, the effect of hot temperature on TB appeared with an about two-week lag and was lower than cold effect. The effect modifications by relative humidity, wind speed and sunshine duration were observed.ConclusionResults indicate that there was a nonlinear correlation with a harvesting effect between temperature and TB in Jinan, and both cold effect and heat effect exist the delayed effect. Results also pointed to the importance of considering effect modification by meteorological factors in assessing temperature effects on incidence of TB. Which might shed light on the strategy of TB prevention and control.