Frank C. Ko
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Frank C. Ko has a total of 24 co-authors. Here are the top co-authors by number of shared publications:
D. Rick Sumner
Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, USA; Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
2 shared publicationsHoomin Lee
Department of Anatomy & Cell Biology, Rush University Medical Center, Chicago, IL, 60612, USA
2 shared publications- Ali Keshavarzian
Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, USA
1 shared publication Amal Adra
Department of Anatomy& Cell Biology, Rush University Medical Center, Chicago, IL 60612, United States of America
1 shared publicationBrandon Willis
UC Davis Mouse Biology Program, University of California, Davis, Davis, CA 95616, USA
1 shared publicationBrittany M. Wilson
Department of Anatomy& Cell Biology, Rush University Medical Center, Chicago, IL 60612, United States of America
1 shared publication
Latest Publications
- Open Access
Chemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review
Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures. Therefore, enhancing our understanding of chemokines is critical for developing appropriate treatment of TMJ. In this review, we discuss chemokines including MCP-1, MIP-1α, MIP-3a, RANTES, IL-8, SDF-1, and fractalkine that are known to be involved in TMJ diseases. In addition, we present novel findings that CCL2 is involved in β-catenin-mediated TMJ osteoarthritis (OA) and potential molecular targets for the development of effective therapies. The effects of common inflammatory factors, IL-1β and TNF-α, on chemotaxis are also described. In conclusion, this review aims to provide a theoretical basis for future chemokine-targeted therapies for TMJ OA.
Open AccessChemokine Regulation in Temporomandibular Joint Disease: A Comprehensive Review
Temporomandibular joint disorders (TMDs) are conditions that affect the muscles of mastication and joints that connect the mandible to the base of the skull. Although TMJ disorders are associated with symptoms, the causes are not well proven. Chemokines play an important role in the pathogenesis of TMJ disease by promoting chemotaxis inflammatory cells to destroy the joint synovium, cartilage, subchondral bone, and other structures. Therefore, enhancing our understanding of chemokines is critical for developing appropriate treatment of TMJ. In this review, we discuss chemokines including MCP-1, MIP-1α, MIP-3a, RANTES, IL-8, SDF-1, and fractalkine that are known to be involved in TMJ diseases. In addition, we present novel findings that CCL2 is involved in β-catenin-mediated TMJ osteoarthritis (OA) and potential molecular targets for the development of effective therapies. The effects of common inflammatory factors, IL-1β and TNF-α, on chemotaxis are also described. In conclusion, this review aims to provide a theoretical basis for future chemokine-targeted therapies for TMJ OA.