Jijian Wang
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Jijian Wang has a total of 4 co-authors. Here are the top co-authors by number of shared publications:
- Guangyi Liu
MD, Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. Conception and design of the study, analysis and interpretation of data, manuscript writing, final approval
1 shared publication - Haitao Gu
MD, Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. Technical procedures, interpretation of data, critical revision, final approval
1 shared publication - Hao Xu
Master, Department of General Surgery, the People's Hospital of Kaizhou District, Chongqing, PR China. Conception and design of the study, analysis and interpretation of data, manuscript writing, final approval
1 shared publication - Yang Li
MD, Department of Gastrointestinal Surgery, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, PR China. Conception and design of the study, analysis and interpretation of data, critical revision,final approval
1 shared publication
Latest Publications
- Open Access
- 1 January 2020
- Published by FapUNIFESP (SciELO) in Acta Cirurgica Brasileira
- Vol. 35 (1) , e202000104
Glutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats
Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important intestinal mucosa protectant in clinical practice and experimental research. However, the mechanisms of its protective effects are still not fully understand. Consequently, this study aimed to explore the potential mechanism of glutamine on ischemia-reperfusion (I/R) injury induced endoplasmic reticulum (ER) stress in intestine. An experimental model of intestinal I/R in rats was established by 1 hour occlusion of the superior mesenteric artery followed by 3 hours of reperfusion. Morphologic changes of intestinal mucosa, apoptosis of epithelial cells, and expression of intestinal Grp78, Gadd153, Caspase-12, ATF4, PERK phosphorylation (P-PERK) and elF2αphosphorylation(P-elF2α) were determined. After I/R, the apoptotic index of intestinal mucosa epithelial cells observably increased with notable necrosis of intestinal mucosa, and the expressions of Grp78, Gadd153, Caspase-12, ATF4, P-PERK and P-elF2αall were increased. However, treatment with glutamine could significantly relieve intestinal I/R injury and apoptosis index. Moreover, glutamine could clearly up-regulate the expression of Grp78, restrain P-PERK and P-elF2α, and reduce ATF4, Gadd153 and Caspase-12 expressions. Glutamine may be involved in alleviating ER stress induced intestinal mucosa cells apoptosis.
- 1 January 2020
- Published by FapUNIFESP (SciELO) in Acta Cirurgica Brasileira
- Vol. 35 (1) , e202000104
Open AccessGlutamine protects intestine against ischemia-reperfusion injury by alleviating endoplasmic reticulum stress induced apoptosis in rats
Glutamine, as an essential part of enteral nutrition and parenteral nutrition agent, has been widely recognized to be a kind of important intestinal mucosa protectant in clinical practice and experimental research. However, the mechanisms of its protective effects are still not fully understand. Consequently, this study aimed to explore the potential mechanism of glutamine on ischemia-reperfusion (I/R) injury induced endoplasmic reticulum (ER) stress in intestine. An experimental model of intestinal I/R in rats was established by 1 hour occlusion of the superior mesenteric artery followed by 3 hours of reperfusion. Morphologic changes of intestinal mucosa, apoptosis of epithelial cells, and expression of intestinal Grp78, Gadd153, Caspase-12, ATF4, PERK phosphorylation (P-PERK) and elF2αphosphorylation(P-elF2α) were determined. After I/R, the apoptotic index of intestinal mucosa epithelial cells observably increased with notable necrosis of intestinal mucosa, and the expressions of Grp78, Gadd153, Caspase-12, ATF4, P-PERK and P-elF2αall were increased. However, treatment with glutamine could significantly relieve intestinal I/R injury and apoptosis index. Moreover, glutamine could clearly up-regulate the expression of Grp78, restrain P-PERK and P-elF2α, and reduce ATF4, Gadd153 and Caspase-12 expressions. Glutamine may be involved in alleviating ER stress induced intestinal mucosa cells apoptosis.