Mostafa Atlam

The proliferation of Internet of Things (IoT) devices challenges deep learning (DL) deployment due to their limited computational power, while cloud offloading introduces high latency and network strain. Fog computing provides a viable middle ground. We present a resource-aware framework that intelligently partitions DL tasks between fog nodes and the cloud using a novel Binary Search-Inspired Recursive (BSIR) optimization algorithm for rapid, low-overhead decision-making. This is enhanced by a novel module that fine-tunes deployment by analyzing memory at a per-layer level. For true adaptability, a Retrieval-Augmented Generation (RAG) technique consults a knowledge base to dynamically select the best optimization strategy. Our experiments demonstrate dramatic improvements over established metaheuristics. The complete framework boosts memory utilization in fog environments to a remarkable 99%, a substantial leap from the 85.25% achieved by standard algorithms like Genetic Algorithms (GA), Simulated Annealing (SA), and Particle Swarm Optimization (PSO). The enhancement module alone improves these traditional methods by over 13% without added computational cost. Our system consistently operates with a CPU footprint under 3% and makes decisions in fractions of a second, significantly outperforming recent methods in speed and resource efficiency. In contrast, recent DL methods may use 51% CPU and take over 90 s for the same task. This framework effectively reduces cloud dependency, offering a scalable solution for DL in the IoT landscape.

Background: Breast cancer is one of the major causes of mortality globally. Therefore, different Machine Learning (ML) techniques were deployed for computing survival and diagnosis. Survival analysis methods are used to compute survival probability and the most important factors affecting that probability. Most survival analysis methods are used to deal with clinical features (up to hundreds), hence applying survival analysis methods like cox regression on RNAseq microarray data with many features (up to thousands) is considered a major challenge.Methods: In this paper, a novel approach applying autoencoder to reduce the number of features is proposed. Our approach works on features reconstruction, and removal of noise within the data and features with zero variance across the samples, which facilitates extraction of features with the highest variances (across the samples) that most influence the survival probabilities. Then, it estimates the survival probability for each patient by applying random survival forests and cox regression. Applying the autoencoder on thousands of features takes a long time, thus our model is applied to the Graphical Processing Unit (GPU) in order to speed up the process. Finally, the model is evaluated and compared with the existing models on three different datasets in terms of run time, concordance index, and calibration curve, and the most related genes to survival are discovered. Finally, the biological pathways and GO molecular functions are analyzed for these significant genes.Results: We fine-tuned our autoencoder model on RNA-seq data of three datasets to train the weights in our survival prediction model, then using different samples in each dataset for testing the model. The results show that the proposed AutoCox and AutoRandom algorithms based on our feature selection autoencoder approach have better concordance index results comparing the most recent deep learning approaches when applied to each dataset. Each gene resulting from our autoencoder model weight is computed. The weights show the degree of effect for each gene upon the survival probability. For instance, four of the most survival-related experimentally validated genes are on the top of our discovered genes weights list, including PTPRG, MYST1, BG683264, and AK094562 for the breast cancer gene expression dataset. Our approach improves the survival analysis in terms of speeding up the process, enhancing the prediction accuracy, and reducing the error rate in the estimated survival probability.

Coronavirus (COVID-19) is one of the most serious problems that has caused stopping the wheel of life all over the world. It is widely spread to the extent that hospital places are not available for all patients. Therefore, most hospitals accept patients whose recovery rate is high. Machine learning techniques and artificial intelligence have been deployed for computing infection risks, performing survival analysis and classification. Survival analysis (time-to-event analysis) is widely used in many areas such as engineering and medicine. This paper presents two systems, Cox_COVID_19 and Deep_ Cox_COVID_19 that are based on Cox regression to study the survival analysis for COVID-19 and help hospitals to choose patients with better chances of survival and predict the most important symptoms (features) affecting survival probability. Cox_COVID_19 is based on Cox regression and Deep_Cox_COVID_19 is a combination of autoencoder deep neural network and Cox regression to enhance prediction accuracy. A clinical dataset for COVID-19 patients is used. This dataset consists of 1085 patients. The results show that applying an autoencoder on the data to reconstruct features, before applying Cox regression algorithm, would improve the results by increasing concordance, accuracy and precision. For Deep_ Cox_COVID_19 system, it has a concordance of 0.983 for training and 0.999 for testing, but for Cox_COVID_19 system, it has a concordance of 0.923 for training and 0.896 for testing. The most important features affecting mortality are, age, muscle pain, pneumonia and throat pain. Both Cox_COVID_19 and Deep_ Cox_COVID_19 prediction systems can predict the survival probability and present significant symptoms (features) that differentiate severe cases and death cases. But the accuracy of Deep_Cox_Covid_19 outperforms that of Cox_Covid_19. Both systems can provide definite information for doctors about detection and intervention to be taken, which can reduce mortality.

Microarray technology is one of the most important recent breakthrough in experimental molecular biology. This novel technology for thousands of genes concurrently allows the supervising of expression levels in cells and has been increasingly used in cancer research to understand more of the molecular variations among tumors so that a more reliable classification becomes attainable. Machine learning techniques are loosely used to create substantial and precise classification models. In this paper, a function called Feature Reduction Classification Optimization (FeRCO) is proposed. FeRCO function uses machine learning techniques applied upon RNAseq microarray data for predicting whether the patient is diseased or not. The main purpose of FeRCO function is to define the minimum number of features using the most fitting reduction method along with classification technique that give the highest classification accuracy. These techniques include Support Vector Machine (SVM) both linear and kernel, Decision Trees, Random Forest, K-Nearest-Neighbors (KNN) and Naïve Bayes (NB). Principle Component Analysis (PCA) both linear and kernel, Linear Discriminant Analysis (LDA) and Factor Analysis (FA) along with different machine learning techniques were used to find a low-dimensional subspace with better discriminative features for better classification. The major outcomes of this research can be considered as a roadmap for interesting researchers in that field to be able to choose the most suitable machine learning algorithm whatever classification or reduction.