Shuyu Han

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This study investigates the pathways to perceived HIV-related stigma among people living with HIV (PLWH) in China, focusing on the roles of social support,

Although antiretroviral therapy has extended the lifespan of people living with HIV (PLWH), psychological symptoms are still prevalent. Given the complexit

Introduction: Understanding the factors influencing whether the sexual partners or spouses (SPS) of people living with HIV (PLWH) undergo HIV testing is critical for improving partner notification and testing strategies. Previous evidence has been inconsistent, often based on small samples, and insufficiently accounts for demographic heterogeneity. This study aimed to identify determinants of SPS testing and to examine whether these differ by age group. Methods: We conducted a cross-sectional study from January 2020 to December 2021 among 2554 newly diagnosed PLWH in Shenzhen, China. Demographic, clinical and behavioural data were collected, along with information on SPS HIV testing within 1 month of diagnosis. Participants were categorised into those with tested SPS (n=1451) and untested SPS (n=1103), and further stratified by age into younger (≤40 years, n=1264) and older (>40 years, n=1290) groups. Statistical analyses included χ ² tests, non-parametric tests and logistic regression. Results: Among the 2554 PLWH, 1451 (56.81%) reported that their SPS had been tested. Increasing age of PLWH was negatively associated with SPS testing (OR=0.988, 95% CI 0.979 to 0.996, p=0.005). In the younger group, educational attainment was identified as a risk factor for their SPS being tested for HIV (OR=1.154, 95% CI 1.009 to 1.319, p=0.036). Conversely, for the older group, unemployment emerged as a risk factor for their SPS being tested for HIV (OR=1.876, 95% CI 1.410 to 2.497, p<0.01), while self-funded antiretroviral therapy (ART) was protective (OR=0.568, 95% CI 0.395 to 0.817, p=0.002). Across both age groups, female gender (OR1=2.230, 95% CI 1.512 to 3.290, P1<0.01; OR2=1.645, 95% CI 1.122 to 2.411, P2=0.011) and frequent condom use (OR1=1.112, 95% CI 1.001 to 1.235, P1=0.047; OR2=1.156, 95% CI 1.042 to 1.282, P2=0.006) were positively associated with SPS testing while homosexual transmission was negatively associated (OR1=0.409, 95% CI 0.313 to 0.535, P1<0.01; OR2=0.368, 95% CI 0.286 to 0.473, P2<0.01). Conclusions: Age modifies the factors influencing SPS HIV testing. Targeted interventions are needed, with emphasis on younger PLWH with limited education, older employed individuals and those self-funding ART. Strengthening disclosure support and tailoring interventions to age and socioeconomic context could improve SPS testing uptake and help reduce intrafamilial HIV transmission.

Objectives: To explore the latent profiles of symptom severity among systemic lupus erythematosus (SLE) patients and analyze the influencing factors associated with these different latent profiles, providing clinical evidence for the management of SLE symptoms. Methods: Using convenience sampling, a questionnaire survey was conducted among SLE patients at Shengjing Hospital of China Medical University employing the SLE Symptom Checklist (SSC) between November 2022 and July 2023. Latent profile analysis (LPA) was performed to assess the severity of patients’ symptoms, and univariate analysis along with multinomial logistic regression was utilized to analyze the factors influencing the latent profiles. Results: A total of 420 patients were included in the study. The results of LPA revealed that the severity of symptoms among SLE patients could be categorized into three latent profiles: mild (75.4%), moderate (17.6%), and severe (6.9%). The multinomial logistic regression analysis showed that male participants were more likely to belong to the “Severe Symptom Type” ( p = 0.046, OR = 2.86). Employed participants had a lower likelihood of being classified into the “Moderate Symptom Type” ( p = 0.027, OR = 1.86) and “Severe Symptom Type” ( p = 0.002, OR = 0.213). Unmarried participants were more likely to be classified into the “Moderate Symptom Type” ( p = 0.027, OR = 1.86). Conclusion: Our study enhanced understanding of SLE’s complexity, identified gender, employment, and marital status as key factors, and advised targeted nursing for high‐risk patients. Clinicians should consider SLE’s system involvement and strengthen social support.

Background: People with HIV (PWH) frequently experience psychological symptoms that can be grouped into distinct profiles, affecting their emotional well-being and social functioning. Identifying the most influential symptoms within each profile is essential for designing effective, individualized interventions. Method: This is a multi-center cross-sectional study involving Chinese PWH. Building on a three-profile model established in our prior research, this study utilized network analysis to identify the most central psychological symptoms within each profile. Results: For Class 1, the five most influential symptoms were “Difficulty in comprehension,” “Anger,” “Inability to handle daily work and study,” “Concerns,” and “Feeling that people are unfriendly or don’t like you.” For Class 2, the key symptoms were “Hostility,” “Feeling that people are unfriendly or don’t like you,” “Sadness,” “Feeling down, depressed, or hopeless,” and “Nausea or vomiting.” For Class 3, the most central symptoms included “Uninspired or uninterested,” “Feeling down, depressed, or hopeless,” “A sense of uncertainty about the future,” “Nervousness or anxiety,” and “Sadness.” Across the entire sample, the most central symptoms were “Uninspired or uninterested,” “Sadness,” “Feeling down, depressed, or hopeless,” “Hostility,” and “Distress”. Conclusions: These findings have important implications for personalized assessment, prevention, and intervention strategies tailored to PWH.