Cuc Thi Thu Nguyen

The quality of life data is often obtained from the non-preference-based instruments with high accuracy and good performance in reflecting changes in the health state. However, these instruments could not generate utility values for the health economic assessments. This study aims to develop and compare the predictive performance of some mapping algorithms from EORTC QLQ-C30 onto the EQ-5D-5L index among chronic myeloid leukemia (CML) patients. A multicenter survey was done via face-to-face interviews (n=494). Four mapping models with independent variables (QLQ-C30 subscales/items, the interaction terms, and demographic and clinical characteristics of patients) were explored via the Bayesian Model Averaging approach. Six regression methods were used to develop the mapping algorithms (Ordinary least squares (OLS), Censored and least absolute deviations, Beta model, Adjusted limited dependent variable model, Linear two-part, and Beta two-part model. The root mean square (RMSE), mean absolute error (MAE), Pearson correlation (r), and Intraclass correlation (ICC) were calculated based on five-fold cross-validation and full population to assess the predictive performance and compare the goodness-of-fit of algorithms. The OLS model 4, including nine QLQ-C30 statistically significant items, two interaction terms, and four demographic and clinical variables, was the best-fit model based on RMSE (0.0769), MAE (0.0578), r (0.7283), and ICC (0.8191) based on the full population. The mapping algorithm converting QLQ-C30 onto EQ-5D-5L value had good predictive validity. The model had many applications in exploring utility in health economic assessments among chronic myeloid leukemia and other cancers.

To evaluate the quality of life and correlated factors in chronic myeloid leukemia patients undergoing long-term imatinib therapy. This was a cross-sectional study recruiting 383 chronic myeloid leukemia patients who presented criteria which included being at least 18 years old, positive BCR-ABL gene and undergoing IM therapy for at least 6 months. Quality of life was evaluated with the EORTC QLQ-C30 questionnaire and defined by EORTC group guidelines. Descriptive statistics, one-way ANOVA and multivariable linear regression test were used. P-value <0.05 was considered statistically significant. The mean age of patients was 46.78 (SD=14.58) years, with the prevalence of disease in the younger group. The mean time of diagnosis and that of imatinib treatment were 4.91 (SD=3.30) years and 4.00 (SD=3.11) years, respectively. Patients showed a significant reduction of Global Health status with the mean score of 68.48 (SD=15.19), a slight decline of functional scores and a notable increase in financial distress. Among symptoms, fatigue got the highest value, as well as pain and insomnia. Multivariable analysis showed that age, income, and comorbidities were powerful factors independently associated with Global health status. However, if fatigue was one of the key aspects analysed, it was the only factor statistically significantly associated with Global Health status (p-value=0.001). Regarding fatigue, age and comorbidities were the two most associated factors. The quality of life of chronic myeloid leukemia patients using imatinib was significantly reduced. Fatigue, age, income, and comorbidities were the main factors associated with Global Health status.

Background/Objectives: Chronic diseases pose a major challenge for healthcare systems, requiring integrated, patient-centered approaches that combine clinical management, prevention, and self-care. Lifestyle Medicine (LM) and lifestyle in general offers complementary frameworks to address these needs. However, the potential integration of LM within community nursing—particularly through the role of Family and Community Nurse (FCN)—has not been comprehensively synthesized. This narrative review aimed to synthesize international evidence on the role of community nursing—particularly FCN—in integrating chronic care management and LM view. Methods: For quality assessment, a narrative review was conducted in accordance with the SANRA criteria to enable the integration of heterogeneous evidence and a comprehensive synthesis of this complex topic. Literature searches were performed in the PubMed–Medline database, and the final screening of references from included studies was used to identify relevant manuscripts. Primary studies published in English over the past ten years were screened and analyzed using the PICOS framework. Sixteen eligible studies were included in the final synthesis. Results: The included studies indicated that nurse-led community interventions in LM view were associated with improvements in self-management, treatment adherence, and selected clinical outcomes, such as blood pressure, glycated hemoglobin, and physical activity levels. Empowerment-based approaches and the use of digital or telehealth tools supported patient engagement and health literacy. At the organizational level, multidisciplinary collaboration, shared protocols, and professional leadership emerged as key factors in sustaining continuity and quality of care, while organizational fragmentation and limited training in behavioral counseling were commonly reported barriers. Conclusions: Community nursing, particularly through FCNs, plays a relevant role in integrating chronic care management and LM approaches, contributing to improved self-management, treatment adherence, and selected clinical outcomes. The evidence highlights the importance of empowerment-based interventions, digital support tools, and multidisciplinary collaboration in enhancing care continuity and patient engagement. Addressing organizational barriers and strengthening behavioral counseling training remain essential to support effective implementation in community settings.

Mục đích: Nghiên cứu nhằm đánh giá tính giá trị và độ tin cậy của bộ câu hỏi Kidney Disease Quality of Life Short Form - KDQOL-SF™ phiên bản 1.3 bằng Tiếng Việt nhằm đo lường chất lượng cuộc sống (CLCS) người bệnh thận mạn. Đối tượng và phương pháp nghiên cứu: Quy trình chuyển ngữ, thích ứng văn hóa và thẩm định bộ câu hỏi được áp dụng. Nghiên cứu mô tả cắt ngang trên 70 người bệnh thận mạn đang điều trị ngoại trú tại Bệnh viện Hữu Nghị từ 01/10 - 31/12/2024, và đánh giá độ tin cậy lặp lại trên 30 người bệnh. Kết quả: Kiểm định giá trị về nội dung phần lớn các câu hỏi có chỉ số I-CVI ≥ 0,78, S-CVI đạt 0,91, phản ánh sự phù hợp trong bối cảnh văn hóa Việt Nam. Về độ tin cậy, mức độ đồng thuận giữa các chuyên gia đạt 0,912. Tính nhất quán nội bộ của bộ công cụ KDQOL-SF™ 1.3 cao, với chỉ số Cronbach’s alpha là 0,90, cho thấy các câu hỏi có sự liên kết chặt chẽ. Độ tin cậy lặp lại cao, với hệ số ICCs > 0,75, khẳng định tính ổn định giữa các lần đo. Kết luận: Bộ câu hỏi KDQOL-SF™ 1.3 Tiếng Việt có tính giá trị và độ tin cậy cao trong việc đo lường CLCS người bệnh thận mạn, đặc biệt là nhóm người bệnh cao tuổi.

Đặt vấn đề: Suy tim mạn tính không những gây ra những tác động kinh tế lớn mà còn tác động tiêu cực đến chất lượng cuộc sống của người bệnh. Mục tiêu: Phân tích chất lượng cuộc sống (CLCS) của người bệnh suy tim mạn tính điều trị ngoại trú tại Bệnh viện Hữu Nghị theo thang đo KCCQ và xác định các yếu tố ảnh hưởng. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả cắt ngang trên 206 người bệnh suy tim mạn đang điều trị ngoại trú tại Bệnh viện Hữu Nghị từ tháng 10-12/2024. CLCS được đánh giá bằng thang đo KCCQ. Hồi quy tuyến tính đa biến được sử dụng để phân tích các yếu tố ảnh hưởng. Kết quả: Người bệnh có độ tuổi trung bình là 79,42 ± 7,49, chủ yếu là nam giới. Điểm chất lượng cuộc sống KCCQ tổng thể trung bình là 71,98 ± 20,81 và có khác biệt có ý nghĩa thống kê giữa các nhóm tuổi, chỉ số Charlson điều chỉnh theo tuổi, số lượng bệnh mắc kèm theo Charlson, nguyên nhân suy tim và phân độ NYHA. Phân tích hồi quy đa biến cho thấy các yếu tố này có ảnh hưởng có ý nghĩa thống kê đến CLCS tổng thể. Kết luận: CLCS của đối tượng nghiên cứu có điểm số trung bình. Tuổi, số lượng bệnh mắc kèm theo Charlson, phân độ NYHA và phân suất tống máu là các yếu tố ảnh hưởng đến điểm CLCS tổng thể.

Background and Aims: Patient satisfaction is a critical metric for assessing the quality of pharmaceutical services in healthcare systems. This study aims to build a questionnaire with various items to comprehensively evaluate patient satisfaction with pharmacy services at the 108 Military Central Hospital and to identify key influential factors in their perception. Methods: The cross‐sectional survey was conducted from August 2023 to October 2023. The face and content validity were assessed by experts. The questionnaire's internal consistency (Cronbach's alpha) and construct validity (exploratory factor analysis) were explored. Multivariate linear regression was used to seek determinants. Results: A total of 457 patients were included for synthesis. The final version of the questionnaire, which had 22 items grouped into four factors (attitude and professional capacity of pharmacy staff, accessibility and transparency, services performed, and infrastructure), showed high consistency and validity. General satisfaction was average (4.09 (SD = 0.628) out of a maximum score of five), with the factor having the lowest score of pharmacist consultants and drug prices despite being the leading national hospital. However, the two factors having the most substantial influence coefficient on satisfaction were the infrastructure (0.433), pharmacy attitude, and professional capacity (0.386). Conclusion: The findings based on the comprehensive questionnaire with 22 items grouped into four factors showed that there were available determinants that needed improvement. Enhancing the quality of the strongest impact aspects of patient satisfaction should be done comprehensively and synchronously. In the case of limited resources, prioritizing actions in phases of time could make them more actionable and beneficial.

The study aimed to investigate the determinants of pharmacy postgraduates’ satisfaction to suggest essential recommendations to enhance educational quality at Hanoi University of Pharmacy in Vietnam. A cross-sectional survey was conducted among 202 postgraduates using structured questionnaires, with 31 multidimensional questions and 1 question addressing overall satisfaction. Cronbach’s alpha was used to evaluate the questionnaire’s internal consistency, Exploratory Factor Analysis (EFA) identified key factors, and multiple linear regression analysis was applied to assess the impact of these factors. Overall satisfaction had a high mean score of 4.49 out of 5 (SD = 0.602). The final 29 questions were retained and divided into four main factors affecting satisfaction after rotating EFA. The dimension of “Support and Evaluation” was the most influential factor (β = 0.475), followed by “Training Organization”, “Facilities and Library”, and “Lecturers and Curriculum”. The variables with the lowest scores needed much more attention, including digital systems (4.2, SD = 0.852), information technology support (4.32, SD = 0.772), activities boosting lifelong learning skills (4.48, SD = 0.624), and the reasonability of the education program’s structure (4.48, SD = 0.608) and the studying program’s schedule (4.45, SD = 0.607). The findings indicate the issues that should be addressed, and have highlighted that improvements in electronic library accessibility and updated curricula are also recommended to further optimize the educational experience of postgraduate students.

Background/Objectives: Functional dyspepsia is associated with abdominal pain and nausea, which leads to reduced quality of life, loss of productivity, and economic loss for patients. Itopride hydrochloride (itopride) stimulates the gastrointestinal smooth muscles, thereby promoting gastric emptying. It has been shown to significantly improve symptoms in patients with functional dyspepsia without severe side effects. Itopride has been available in Vietnam for many years; however, the cost-effectiveness of the drug has not been established. The aim of this study is to estimate the cost-effectiveness of itopride for the treatment of functional dyspepsia in Vietnam. Methods: A 3-stage Markov model with the following health states—controlled functional dyspepsia, uncontrolled functional dyspepsia, and dead—was developed. Functional dyspepsia was used to assess itopride over 10 years using 8-week cycles. A broader Vietnamese societal perspective was assumed for the analysis. Input was retrieved from the literature and through local clinical input from physicians in Vietnam. Output was reported as an incremental cost-effectiveness ratio (ICER) per quality-adjusted life years (QALY). A GDP/capita threshold (very cost-effective: 1 × GDP = Vietnamese Dong (VND) 64.1 M, cost-effective: 3 × GDP = VND 192.2 M) was used as recommended by the WHO in Vietnam. One-way and probabilistic sensitivity analyses were performed. Results: Itopride use resulted in an additional 0.28 QALYs at an extra cost of VND 11.2 M. This resulted in an ICER of VND 39.7 M per QALY, which is lower than the threshold of VND 192.2 M. One-way sensitivity analyses showed that the ICER was sensitive to varying the efficacy VND 31.8 M to VND 88.3 M), cost of itopride (ICER: VND 43.1 M to VND 56.5 M), and the health utility values (ICER: VND 45.2 M to VND 55.3 M). More than 80% of the simulations in the probabilistic sensitivity analysis were cost-effective at the 1 × GDP (VND 64.1 M) threshold, and 91.3% were cost-effective at the 3 × GDP (VND 192.2 M) threshold. Conclusion: This study shows that itopride hydrochloride is a very cost-effective treatment for functional dyspepsia in Vietnam, with the ICER (VND 39.7 M/QALY) being even lower than the 1 × GDP (VND 64.1 M) threshold.

Introduction: The Diagnostic and Statistical Manual of Mental Disorders (DSM-5) defines depression as a persistent period of sadness or a reduced interest in everyday activities lasting at least two weeks. Anhedonia, a key symptom of depression, is notable for its significance and is regarded as the second most important factor related to non-somatic issues, following closely behind a depressed mood. This study primarily investigates how excessive or problematic use of Internet-connected devices affects the mood and emotions of young people, with a specific emphasis on anhedonia. Additionally, it explores associated socio-behavioral changes and examines the interaction between IA and depression. Methods: This systematic review was conducted following PRISMA international guidelines. Searches were performed in PubMed, Cochrane Library (Clinical Trials section), Scopus, Embase, PsycInfo, and grey literature sources like Google Scholar. A predefined search strategy using Boolean operators was employed, and two researchers independently selected papers, with a third researcher resolving any discrepancies. Manual reviews were conducted to minimize selection bias. Results: Out of 3812 records, 7 studies were included. The findings suggest that social anhedonia correlates with higher levels of IA, particularly among adolescents and young adults. In some studies, loneliness was identified as a mediator between social anhedonia and social functioning, indicating a complex interplay of emotional factors. Other investigations revealed that increased screen time is associated with a heightened risk of developing addiction-related behaviors. Practical Implications and Conclusions: This review highlights the key role of anhedonia in the development of Internet addiction (IA) among young people, particularly through its impact on emotional regulation and social interactions. Addressing psychological and environmental factors is essential for developing targeted strategies to prevent and manage IA and its related mental health challenges.