Roy Heyne
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Roy Heyne has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
- Carmina Erdei
Department of Pediatrics, Division of Newborn Medicine, Brigham and Women’s Hospital, Boston, USA
1 shared publication - Cindy Hsin Ju Liu
Department of Pediatrics, Brigham and Women’s Hospital, Boston, USA
1 shared publication - Hao Huang
Children’s Hospital of Philadelphia
1 shared publication - Lina F. Chalak
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center and Children’s Medical Center, Dallas, USA
1 shared publication - Michelle Machie
University of Texas Southwestern Medical Center
1 shared publication - Minhui Ouyang
The Children's Hospital of Philadelphia
1 shared publication
Latest Publications
- 1 March 2021
- Published by Elsevier in Early Human Development
- Vol. 154, 105278
Parent mental health and neurodevelopmental outcomes of children hospitalized in the neonatal intensive care unit
- 1 March 2021
- Published by Elsevier in Early Human Development
- Vol. 154, 105278
Parent mental health and neurodevelopmental outcomes of children hospitalized in the neonatal intensive care unit
- Open Access
Diffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds
Brain cerebral cortical architecture encoding regionally differential dendritic arborization and synaptic formation at birth underlies human behavior emergence at 2 years of age. Brain changes in 0-2 years are most dynamic across lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development, and identify biomarkers for early detection and tailored intervention in atypical development. Here, we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.
Open AccessDiffusion-MRI-based regional cortical microstructure at birth for predicting neurodevelopmental outcomes of 2-year-olds
Brain cerebral cortical architecture encoding regionally differential dendritic arborization and synaptic formation at birth underlies human behavior emergence at 2 years of age. Brain changes in 0-2 years are most dynamic across lifespan. Effective prediction of future behavior with brain microstructure at birth will reveal structural basis of behavioral emergence in typical development, and identify biomarkers for early detection and tailored intervention in atypical development. Here, we aimed to evaluate the neonate whole-brain cortical microstructure quantified by diffusion MRI for predicting future behavior. We found that individual cognitive and language functions assessed at age of 2 years were robustly predicted by neonate cortical microstructure using support vector regression. Remarkably, cortical regions contributing heavily to the prediction models exhibited distinctive functional selectivity for cognition and language. These findings highlight regional cortical microstructure at birth as potential sensitive biomarker in predicting future neurodevelopmental outcomes and identifying individual risks of brain disorders.