Kathleen A. Leppig
Research Subjects
Research Interests
Kathleen A. Leppig has a total of 31 co-authors. Here are the top co-authors by number of shared publications:
- Alanna Kulchak Rahm
Geisinger
1 shared publication - Carrie L. Blout Zawatsky
Brigham and Women's Hospital Boston Massachusetts USA
1 shared publication - Christin Hoell
Center for Genetic Medicine, Northwestern University, Chicago, IL 60611, USA
1 shared publication - Cynthia A. Prows
Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA
1 shared publication - Ellen Wright Clayton
Center for Biomedical Ethics and Society, Vanderbilt University Medical Center , Nashville, TN 37203
1 shared publication - Eric B. Larson
Kaiser Permanente Washington Health Research Institute, Kaiser Permanente of Washington, Seattle, WA 98101, USA
1 shared publication
Latest Publications
- Open Access
- 27 April 2020
- Published by MDPI AG in Journal of Personalized Medicine
- Vol. 10 (2) , 30
Returning Results in the Genomic Era: Initial Experiences of the eMERGE Network
A goal of the 3rd phase of the Electronic Medical Records and Genomics (eMERGE3) Network was to examine the return of results (RoR) of actionable variants in more than 100 genes to consenting participants and their healthcare providers. Each of the 10 eMERGE sites developed plans for three essential elements of the RoR process: Disclosure to the participant, notification of the health care provider, and integration of results into the electronic health record (EHR). Procedures and protocols around these three elements were adapted as appropriate to individual site requirements and limitations. Detailed information about the RoR procedures at each site was obtained through structured telephone interviews and follow-up surveys with the clinical investigator leading or participating in the RoR process at each eMERGE3 institution. Because RoR processes at each of the 10 sites allowed for taking into account differences in population, disease focus and institutional requirements, significant heterogeneity of process was identified, including variability in the order in which patients and clinicians were notified and results were placed in the EHR. This heterogeneity in the process flow for eMERGE3 RoR reflects the “real world” of genomic medicine in which RoR procedures must be shaped by the needs of the patients and institutional environments.
- 27 April 2020
- Published by MDPI AG in Journal of Personalized Medicine
- Vol. 10 (2) , 30
Open AccessReturning Results in the Genomic Era: Initial Experiences of the eMERGE Network
A goal of the 3rd phase of the Electronic Medical Records and Genomics (eMERGE3) Network was to examine the return of results (RoR) of actionable variants in more than 100 genes to consenting participants and their healthcare providers. Each of the 10 eMERGE sites developed plans for three essential elements of the RoR process: Disclosure to the participant, notification of the health care provider, and integration of results into the electronic health record (EHR). Procedures and protocols around these three elements were adapted as appropriate to individual site requirements and limitations. Detailed information about the RoR procedures at each site was obtained through structured telephone interviews and follow-up surveys with the clinical investigator leading or participating in the RoR process at each eMERGE3 institution. Because RoR processes at each of the 10 sites allowed for taking into account differences in population, disease focus and institutional requirements, significant heterogeneity of process was identified, including variability in the order in which patients and clinicians were notified and results were placed in the EHR. This heterogeneity in the process flow for eMERGE3 RoR reflects the “real world” of genomic medicine in which RoR procedures must be shaped by the needs of the patients and institutional environments.