Gaelle Neveu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Gaelle Neveu has a total of 18 co-authors. Here are the top co-authors by number of shared publications:
- Abdoulaye Sissoko
INSERM-U1134, BIGR, Universite Paris Cite and Universite des Antilles, Paris, France
1 shared publication - Anthony Marteau
Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Sorbonne Paris Nord University, 93009 Bobigny, France
1 shared publication - Catherine Lavazec
Institut Cochin, Université Paris Cité, CNRS, INSERM, 75014 Paris, France
1 shared publication - Daniela Barbieri
Universite de Paris, Inserm U1016, CNRS UMR 8104, Institut Cochin, France
1 shared publication Diana Roman
Universite de Paris, IRD 261, MERIT, France
1 shared publication- Florian Dupuy
Laboratoire d’Excellence GR-Ex, 75015 Paris, France
1 shared publication
Latest Publications
- Open Access
Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability
To ensure the transport of nutrients necessary for their survival, Plasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. These New Permeation Pathways (NPP) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of NPP has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. Here, we show that NPP are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. Our results indicate that NPP are regulated by cyclic AMP (cAMP) signaling cascade during sexual parasite stages, and that the decrease in cAMP levels in mature stages results in a slowdown of NPP activity. We also show that NPP facilitate the uptake of artemisinin derivatives and that phosphodiesterase (PDE) inhibitors can reactivate NPP and increase drug uptake in mature gametocyte-infected erythrocytes. These processes are predicted to play a key role in P. falciparum gametocyte biology and susceptibility to antimalarials.
Open AccessPlasmodium falciparum sexual parasites regulate infected erythrocyte permeability
To ensure the transport of nutrients necessary for their survival, Plasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. These New Permeation Pathways (NPP) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of NPP has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. Here, we show that NPP are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. Our results indicate that NPP are regulated by cyclic AMP (cAMP) signaling cascade during sexual parasite stages, and that the decrease in cAMP levels in mature stages results in a slowdown of NPP activity. We also show that NPP facilitate the uptake of artemisinin derivatives and that phosphodiesterase (PDE) inhibitors can reactivate NPP and increase drug uptake in mature gametocyte-infected erythrocytes. These processes are predicted to play a key role in P. falciparum gametocyte biology and susceptibility to antimalarials.