SEStéphane Egée

Stéphane Egée

Sorbonne Université
*This is an algorithmically generated author record based on publicly available information.
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Stéphane Egée has a total of 35 co-authors. Here are the top co-authors by number of shared publications:

  • Abdelrazak Aissat

    Département de Biochimie‐Biologie Moléculaire, Pharmacologie, Génétique Médicale, AP‐HP Hôpitaux Universitaires Henri Mondor 51 Avenue du Maréchal de Lattre de Tassigny Créteil Val‐deMarne France

    1 shared publication
  • Abdoulaye Sissoko

    INSERM-U1134, BIGR, Universite Paris Cite and Universite des Antilles, Paris, France

    1 shared publication
  • Anthony Marteau

    Parasitology-Mycology Department, Avicenne Hospital, AP-HP, Sorbonne Paris Nord University, 93009 Bobigny, France

    1 shared publication
  • Ariane Lunati‐Rozie

    Département de Biochimie‐Biologie Moléculaire, Pharmacologie, Génétique Médicale, AP‐HP Hôpitaux Universitaires Henri Mondor Créteil France

    1 shared publication
  • Benoît Funalot

    Département de Biochimie‐Biologie Moléculaire, Pharmacologie, Génétique Médicale, AP‐HP Hôpitaux Universitaires Henri Mondor 51 Avenue du Maréchal de Lattre de Tassigny Créteil Val‐deMarne France

    1 shared publication
  • Bertrand Godeau

    Department of Internal Medicine and Clinical Immunology, coordinating center of the national reference center for adult' immune cytopenias, Henri Mondor university hospital, Assistance Publique Hôpitaux de Paris, Université Paris-Est Créteil, Paris, France

    1 shared publication

Latest Publications

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    Multiple thrombosis in a patient with Gardos channelopathy and a new KCNN4 mutation

    by Lamisse Mansour‐Hendili, Stéphane Egée, David Monedero‐Alonso, Guillaume Bouyer, Bertrand Godeau, Bouchra Badaoui, Ariane Lunati, Clara Noizat, Abdelrazak Aissat, Laurent Kiger, et al.

    Cited by 13
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    Plasmodium falciparum sexual parasites regulate infected erythrocyte permeability

    by Guillaume Bouyer, Daniela Barbieri, Florian Dupuy, Anthony Marteau, Abdoulaye Sissoko, Marie-Esther N’dri, Gaelle Neveu, Laurianne Bedault, Nabiha Khodabux, Diana Roman, et al.

    To ensure the transport of nutrients necessary for their survival, Plasmodium falciparum parasites increase erythrocyte permeability to diverse solutes. These New Permeation Pathways (NPP) have been extensively characterized in the pathogenic asexual parasite stages, however the existence of NPP has never been investigated in gametocytes, the sexual stages responsible for transmission to mosquitoes. Here, we show that NPP are still active in erythrocytes infected with immature gametocytes and that this activity declines along gametocyte maturation. Our results indicate that NPP are regulated by cyclic AMP (cAMP) signaling cascade during sexual parasite stages, and that the decrease in cAMP levels in mature stages results in a slowdown of NPP activity. We also show that NPP facilitate the uptake of artemisinin derivatives and that phosphodiesterase (PDE) inhibitors can reactivate NPP and increase drug uptake in mature gametocyte-infected erythrocytes. These processes are predicted to play a key role in P. falciparum gametocyte biology and susceptibility to antimalarials.