Müjgan Gürler

The aim of this study was to evaluate age-related differences in periodontal inflammatory burden among systemically healthy patients with periodontitis using Periodontal Inflamed Surface Area (PISA) and conventional periodontal clinical parameters.Materials and MethodsThis retrospective cross-sectional study included 72 systemically healthy patients aged 25–64 years who were diagnosed with Stage III–IV periodontitis. Participants were categorized into three age groups: 25–44, 45–54, and 55–64 years. Plaque percentage (P%), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), and number of teeth were evaluated in all participants. PISA values were calculated using routinely recorded PPD and BOP data from six sites per tooth. Intergroup comparisons were performed using Kruskal–Wallis and Mann–Whitney U tests. Associations between variables were analyzed using Spearman correlation analysis. Multiple linear regression analysis was conducted to identify the determinants of PISA (p

Background: The blood glucose levels in people with prediabetes mellitus (PDM) are regarded as too high to be normal but below the cutoff for diabetes mellitus (DM). Clinical indicators for PDM patients include impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and/or hemoglobin A1c (HbA1c) levels between 5.7 and 6.4% (39–47 mmol/mol). PDM has been shown to raises the risk of cardiovascular disease (CVD) and mortality. Meanwhile, death and morbidity can be predicted by the new ventricular repolarization features of the electrocardiogram (ECG). Several studies have analyzed the connection between DM and the ventricular repolarization characteristics of ECG; however, few studies have examined the connection between PDM and these ventricular repolarization characteristics. This study evaluated the ECG ventricular repolarization parameters in individuals with PDM. Methods: A retrospective case-control design was used. Randomly selected participants included 79 PDM patients (30 men, mean age: 39.7 ± 5.7 years) and 79 controls (30 men, mean age: 39.8 ± 5.2 years). ECG intervals analyzed were the distance from the beginning of the Q wave to the end of the T wave (QT), the distance between Q and S waves (QRS), the distance between the T wave’s termination and point J (JT), and the distance between the peak and endpoint of the T wave (Tp-e), along with corrected and derived measures (corrected QT interval (QTc), the difference between the maximum and smallest QT intervals (QTd), corrected QTd (QTdc), corrected JT interval (JTc), Tp-e/QT, Tp-e/QTc, Tp-e/JT, Tp-e/JTc). Patient records were retrieved from the institution’s database. Results: Both groups had comparable averages for age, gender, smoking, hyperlipidemia, body mass index (BMI), (p > 0.05 for each). Similarly, both groups had similar QT, QRS, and JT intervals. PDM patients had significantly greater heart rates (bpm), and QTc, QTd, QTdc, JTc, and Tp-e intervals (millisecond, ms) than the control group. The results were deemed significant when HbA1c levels were associated with every employed ECG measurement in our investigation. Conclusions: In our study, the HbA1c value was shown to be moderately positively correlated with the heart rate and QTc, QTd, QTdc, JTc, and Tp-e intervals, all of which were determined to be significant. Additionally, the HbA1c value showed a weak positive correlation with Tp-e/QT, Tp-e/JT ratios, which were statistically significant. This study showed that patients with PDM are prone to ventricular arrhythmia in the early period of the disorder.

The Arias-Stella (AS) reaction is hormone-dependent atypical endometrial changes characterized by hyperplasia, hypertrophy, vacuolization, pronounced nuclear atypia, pronounced nuclear pleomorphism, and prominent nuclear hyperchromasia in glandular epithelial cells. It is very rare to see AS-related changes in extra uterine areas, especially in an endocervical polyp. Since this benign lesion is very similar to misdiagnoses such as adenocarcinoma, it is very critical to recognize AS reaction in extrauterine areas. The interpretation of pathological findings involves many difficulties, for example, due to the generally small size and fragmentation. Considering the clinical history and good interpretation of the nuclear details are extremely important for correct diagnosis. Here, we present the frightening cellular changes associated with AS observed in an endocervical polyp encountered after abortion in a middle-aged pregnant woman, together with the literature findings.

Aim: The use of biocompatible bone tissue grafts, filling materials, bone minerals, and implants, particularly in medicine and dentistry studies, has expanded significantly in recent years, as have expectations from the materials. We aimed to test the biocompatibility and wound and tissue biocompatibility of many grafts and similar materials used in medicine and dentistry with tests such as cytotoxicity, scratch assay, cell adhesion, and hemolysis. Material and Method: In this study, the interaction of fluorine ions with a dental material was investigated by biological activity experiments. In addition, studies were carried out on important osteoblast cells for tissue regeneration control. For this process, cell migration analysis, which we do not encounter frequently in the literature, was used to examine the interaction of cells with biomaterials more sharply. Results: Flor ions do not create a cytotoxic effect and also increase the viability of osteoblasts which is important for tissue regeneration and are bone precursor cells. Conclusions: In this study, in which the efficiency of osteoblast cells was discussed, it was concluded that 2% fluorine added material had more effective biological results compared to the increase in fluorine ion ratio.

Adenomiyoepitelyoma, meme lobül ve kanallarının hem epitel hem de miyoepitelyal hücrelerin proliferasyonu ile karakterize, nadir görülen benign bir meme neoplazisidir. Kendine özgü risk faktörleri ve radyolojik bulguları olmayan bu tümör çoğunlukla ileri yaşlarda görülür. Epitelyal ve miyoepitelyal hücrelerin bifazik proliferasyonu ile meydana gelir ve içerisinde normal meme lobülleri ve duktuslarını da barındırır. Bu tümör tanı açısından oldukça zordur ve radyolojik ve patolojik olarak birçok tuzakları içerir. Malign dejenerasyon literatürde bildirilmekle beraber nadir bir durumdur. Bu çalışmada radyolojik olarak şüpheli bulgular gösteren ve patolojik olarak adenomiyoepitelyoma olarak raporlanan nadir bir olgu sunduk.

Background. Diabetes mellitus (DM) is a multisystemic, chronic disease that affects many organs. Coronary artery disease (CAD) is the leading cause of death in patients with DM. The electrocardiogram’s new ventricular repolarization parameters can predict mortality and morbidity. The ventricular repolarization indices were examined in diabetic patients with a CAD diagnosis in this study. Methods. The study group consisted of 84 DM patients (51 males; mean age 58.8 ± 6.6) with noncritical CAD. The control group consisted of 84 DM patients (47 males; mean age 58.7 ± 8.8) with a normal coronary artery. The intervals of QT, QRS, JT, and Tp‐e were all measured. Tp‐e/QT, Tp‐e/QTc, Tp‐e/JT, and Tp‐e/JTc ratios were determined with QTc, QTd, QTdc, and JTc intervals. Results. Heart rate (74.4 ± 13.1 vs. 70.0 ± 13.6 bpm, p: 0.036), QT (381.0 ± 30.3 vs. 368.6 ± 29.1 ms, p: 0.008), QTc (407.5 (359–450) vs. 389 (339–430) ms, p < 0.001), QTd (25.1 ± 6.2 vs. 21.9 ± 9.9 ms, p: 0.013), QTdc (26.7 ± 6.1 vs. 23.1 ± 10.8 ms, p: 0.010), Tp‐e (95.7 ± 12.2 vs. 73.6 ± 9.8 ms, p < 0.001), JT (293.8 ± 22.0 vs. 283.5 ± 30.9 ms, p: 0.014), and JTc (313.6 ± 12.3 vs. 302.4 ± 33.7 ms, p = 0.005) intervals, and Tp‐e/QT (0.25 ± 0.03 vs. 0.20 ± 0.03 ms, p < 0.001), Tp‐e/QTc [0.23 (0.19–2.33) vs. 0.19 (0.14–0.25) ms, p = 0.007], Tp‐e/JT (0.33 ± 0.04 vs. 0.26 ± 0.04 ms, p < 0.001), and Tp‐e/JTc (0.30 ± 0.03 vs. 0.24 ± 0.03 ms, p < 0.001) ratios were all found to be significantly higher in diabetic patients with noncritical CAD. Conclusion. In this study, ventricular repolarization markers on the surface ECG were found to be elevated in diabetic CAD patients. These variables may be related to fatal arrhythmic events. To be sure, large‐scale, randomized controlled trials are required.

Aim: As the number of people with diabetes mellitus is increasing globally, its consequences are worsening. People with diabetes are prone to foot problems that develop due to prolonged periods of high blood sugar levels diabetic foot disease (DFD) results in a major global burden for patients and the health care system. It is important to fully understand the characteristics of DFD, which is a major cause of mortality, for early diagnosis and definitive treatment. Our study aimed to examine DFD studies and guide the studies to be planned in the future. Materials and methods: In our study, the Web of Science (WOS) database was scanned to search for publications until February 28, 2021. While the data obtained in our study were analyzed to present various bibliometric indicators, the maps were visualized using the VOS viewer program (VOS viewer). The Hirsch (H) index and impact factor (IF) of the publishing journal were used as indicators of the impact of the publications. The publications containing the keywords 'Diabetic foot' and 'Diabetic foot disease' or 'Diabetic foot infection' were examined. Results: A total of 802 publications were reached from the WOS database according to the search criteria. The most publications were from the USA (32.941%), Turkey (9.412%), and England (8.431%). Most of the publications were articles (63,6%) and meeting abstracts (16,9%). 19,4% of the publications were in the endocrinology and metabolism area. The average number of citations of these 802 publications was found to be 20,98. The H index was found to be 53. It was determined that the number of citing rates of publications on diabetic foot infections has increased over the years, however, it was determined that the number of publications on this subject decreased over the years. Conclusion: This is the first bibliometric study on DFD. Bibliometric analysis should be used more widely to evaluate the quality of the increasing academic paper and guide the missing study issues.

Aim: Although celiac disease is a gluten-related enteropathy, it is a disease that can affect the whole body due to malabsorption. On the other hand, it paves the way for a continuous chronic inflammation due to antigen exposure. It is known that chronic inflammation has systemic effects on the body. Systemic effects of celiac disease may trigger fibromyalgia syndrome (FMS) through different mechanisms. Our study aims to determine the prevalence of FMS in Celiac patients and to evaluate the effect of FMS on Celiac patients. Methods: Our study included 24 Celiac patients (7 active, 17 under the celiac diet) and 20 healthy controls who were admitted to our Gastroenterology outpatient clinic between 01 February and 10 June 2019. 2010 American Colloge of Rheumatology criteria were used for the diagnosis of FMS. The FMS score was calculated from the sum of WSPI (widespread pain index) and SSS (symptom severity score). Fibromyalgia impact questionnaire applied to all participants Results: When the frequency of FMS in celiac patients and control groups were compared, no significant difference was found; 12.5% in celiac patients and 5% in the control group (p = 0.61). The frequency of FMS in men and women was similar. The FMS effect scale scores were compared with those without FMS, there was no significant difference in the control group (23.9±18.8 and 21.5±0; p:0.90). Although the FMS effect score was higher in patients with celiac disease than those without FMS, it did not reach significance (51.9±25.5 vs. 28.5±17.7; p:0.25). Conclusion: This is the first study showing the frequency of FMS in Celiac patients in the Turkish population. FMS does not increase in frequency in Celiac disease compared to the normal population. The activity has no effect on FMS in celiac disease. Studies on a larger population are needed. Amaç: Çölyak hastalığı, glüten ilişkili bir enteropati olmakla birlikte malabsorbsiyona bağlı bütün vücudu etkileyebilen bir hastalıktır. Diğer yandan antijen maruziyeti sebebiyle süreğenleşmiş bir kronik inflamasyona da zemin hazırlamaktadır. Kronik inflamasyonun vücutta sistemik etkilerinin olduğu bilinmektedir. Çölyak hastalığının sistemik etkileri farklı mekanizmalar üzerinden fibromiyalji sendromunu (FMS) tetikliyor olabilir. Çalışmamızın amacı Çölyak hastalarında FMS prevalansını belirlemek ve FMS’nun Çölyak hastaları üzerindeki etkisini değerlendirmektir. Metod: Çalışmamıza, 01 Şubat-10 Haziran 2019 tarihleri arasında Gastroenteroloji kliniğimize başvuran 24 Çölyak hastası (7 aktif, 17 Çölyak diyeti altında) ve 20 sağlıklı kontrol dahil edildi. FMS tanısı için 2010 American Colloge of Rheumatology kriterleri kullanıldı. WSPI (yaygın ağrı indeksi), SSS (somatik semptom ağırlık skoru) ve toplamından FMS skoru hesaplandı. Bütün katılımcılara fibromiyalji etki anketi uygulandı. Veriler istatistiksel olarak karşılaştırıldı. Bulgular: Çölyak hastaları ve kontrol grubunda FMS sıklığı birbirleriyle karşılaştırıldığında anlamlı farklılık saptanmadı; Çölyak hastalarında %12,5, kontrol grubunda %5 (p:0,61). Kadın ve erkeklerdeki FMS sıklığı benzerdi. Gruplar arasında WSPI, SSS ve FMS skorları açısından anlamlı fark yoktu. FMS etki skalası skorları FMS olanlar ile olmayanlar karşılaştırıldığında kontrol grubunda anlamlı fark yoktu (23,9±18,8 ve 21,5±0; p:0,90). Çölyak hastalığı olanlarda, FMS etki skoru FMS olanlarda olmayanlara göre daha yüksek olmasına rağmen anlamlılık düzeyine ulaşmamıştır (51,9±25,5 ve 28,5±17,7; p:0,25). Sonuç: Türk toplumunda Çölyak hastalarında FMS sıklığını gösteren ilk çalışmadır. FMS, normal popülasyona göre Çölyak hastalığında sıklığı artmamaktadır. Çölyak hastalığında aktivitenin FMS üzerine etkisi yoktur. FMS tanısı olan Çölyak hastalarında olmayanlara göre hayat kalitesi daha çok etkilenmektedir. Daha geniş bir popülasyonda yapılacak çalışmalara ihtiyaç vardır.