Daniel Yagudaev

Metastasis of prostate cancer to the epididymis is exceptionally rare, with only 23 cases reported. This case highlights diagnostic challenges and underscores the role of advanced imaging in detecting atypical metastases. Aim. To present a case of acinar adenocarcinoma metastatic to the left epididymis, analyzing pathogenesis, diagnostic approaches, and management strategies. A 67-year-old male with prostate cancer (initial cT2cN0M0, Gleason 8) underwent laparoscopic radical prostatectomy with pelvic lymphadenectomy (21.09.2023). Histopathology revealed pT3bN1 (3/24 nodes), Gleason 9 (4 + 5), positive surgical margin (R1). Adjuvant radiotherapy (total dose 70.8 Gy) and androgen deprivation therapy (goserelin) were administered. Upon biochemical recurrence (prostate-specific antigen (PSA) 2 ng/mL), positron emission tomography combined with computed tomography, with prostate-specific membrane antigen (PSMA-PET/CT) detected lesions in the left epididymis, lung, and bones. Bilateral orchiectomy was performed. Histological examination included morphology and immunohistochemical study (PSA, PSMA, NKX3.1). PSMA-PET/CT showed intense uptake in the left epididymis (standardized uptake value maximum 12.7), left lung (6 mm nodule), and bones. Orchiectomy confirmed metastatic adenocarcinoma in the epididymis with vascular/perineural invasion, morphologically identical to primary prostate cancer. IHC: PSA (+++), PSMA (+++), PLAP (−), OCT3/4 (−), excluding germ cell tumor. HRR gene testing revealed no mutations. Enzalutamide (160 mg/day) was initiated due to progression. Epididymal metastases from prostate cancer are anecdotal (0.01 %), requiring differentiation from primary testicular tumors. PSMA-PET/CT is pivotal for detecting atypical recurrences (sensitivity 85–92 % at PSA 0.5 ng/mL). Aggressive features (Gleason 9, R1, early recurrence) predict multifocal progression, including rare sites. Orchiectomy serves dual diagnostic and therapeutic purposes (androgen deprivation). Reporting such cases is crucial for optimizing management algorithms.

Renal cell carcinoma (RCC) remains one of the leading oncological pathologies. A feature of the epidemiology of RCC is its predominant prevalence both in the morbidity structure of the elderly (60 years and older) (3.7 %) and in the young age group of 30–59 years (4.5 %). In the present rare clinical observation of a patient with a late recurrence of RCC 10 years after nephrectomy, salvage surgical treatment (metastasectomy), rapid progression on first-line sunitinib targeted therapy and subsequent long-term durable tumor response to targeted therapy with multikinase inhibitor cabozantinib. In this observation of a patient with multifocal visceral metastases in the 2nd line, stabilization of disease was achieved during 4 years cabozantinib monotherapy, treatment continues to the present. Despite the extremely long continuous intake of cabozantinib at full dose and patient’s morbidity, no dose reduction or temporary breaks in therapy were required. Patient tolerates treatment satisfactorily with controlled adverse events – II grade drug-induced steatohepatitis with moderate cytolysis syndrome, I grade toxic dermatitis, I grade nause. Patient’s quality of life is preserved.

Background: There is limited published evidence regarding the incidence of intraoperative and postoperative events and the effect of percutaneous nephrolithotomy (PCNL) in supine and prone positions and laparoscopic pyelolithotomy on kidney function in patients with large and complex calculi. Materials and methods: We evaluated the surgical outcomes of 97 patients with large and complex kidney stones. The patients were divided into 3 groups: those who underwent PCNL in the prone position, PCNL in the supine position, and pyelolithotomy by laparoscopy and retroperitoneoscopy. General surgical outcomes, size of residual stones, stone-free rate, glomerular filtration rate (GFR), and split GFR obtained from Tc-99m renal dynamic scintigrams were analyzed. Results: Percutaneous nephrolithotomy in the prone position was correlated with improved function of the affected kidney. In the supine PCNL group, none of the analyzed indicators demonstrated a significant difference. Dynamic nephroscintigrams revealed negative changes in terms of accumulation and secretion of the affected kidney. A slight decrease in creatinine clearance was noted. However, positive dynamics in split GFR and secretory index were seen in this group. The laparoscopic group showed positive results in all analyzed parameters. However, full assessment of the function of the affected kidney in this group was limited due to restricted use of laparoscopic pyelolithotomy for complex stones. Conclusions: Percutaneous nephrolithotomy in the prone position resulted in the most favorable renal functional outcomes for patients with high-grade renal calculi, whereas a laparoscopic approach may be preferred for patients with stones of lower grades. The most significant factors that adversely affected renal function were intraoperative bleeding volume, kidney stone size and density, and body mass index.

The article is dedicated to the modern methods of diagnosis and treatment of oligometastatic prostate cancer based on a large amount of literature data. The main goal of metastasis-directed therapy in oligometastatic prostate cancer is slowing of metastatic process, increased time to palliative androgen deprivation therapy, and cure of the patient. Currently, there is not enough high-quality data on treatment and effectiveness of metastasis-directed therapy. Terminology standardization, use of the full potential of positron emission tomography/computed tomography imaging with prostate-specific membrane antigen, its combination with molecular and genetic tests, and stratification of risk factors for each individual patient are necessary.

Malignant tumors of the urachus are extremely rare. The frequency of urachal malignancy makes 1: 5 000 000 cases, which is 0.35–1.2 % of all the cases of bladder cancer. The small series of observations described in the literature do not allow us to formulate statistically reliable and unambiguously recommended statements about the optimal methods of diagnostics and treatment of this pathology. The diagnosis of urachus diseases is often challenging. This is associated with both the asymptomatic course and the variety of clinical flow of the disease. The treatment strategies are also largely ambiguous and ranging from the defining the indications for surgical treatment to the aggressiveness of surgical intervention. Meanwhile, 20 % of patients with urachal cancer have distant metastases at the time of detection. With everything listed above, (low frequency, little research done and aggressiveness of the flow) it makes every clinical observation of this disease valuable.This article is a clinical observation providing with the information upon the diagnosis, the choice of strategies and surgical treatment of urachal cancer in a patient suffering from multimorbidity. Volumetric formation of the bladder was detected in this patient during additional examination for macrohematuria. Cystoscopy with transurethral resection and subsequent morphological examination verified invasive mucinous adenocarcinoma of the bladder with the growth into the lamina propria and without the signs of vascular and perineural invasion. The patient underwent laparotomy, radical resection of the bladder with extended pelvic lymphadenectomy. The umbilicus, urachus and the bladder wall with the tumor, as well as the adjacent peritoneum, were excised as a single block during the surgical intervention. Morphological examination verified mucinous adenocarcinoma of urachus. The postoperative period was uneventful.There have been no signs of disease progression observed during 10-month follow-up period.

Background. High dose-rate brachytherapy is a new method of interstitial radiation therapy for treatment of localized prostate cancer. The difference from low dose therapy is temporary implantation of radiation sources with targeted high dose-rate irradiation of the affected organ.Aim. To evaluate 3-year effectiveness and safety of high dose-rate brachytherapy in patients with infravesical obstruction. Materials and methods. Between January of 2017 and December of 2019 at the Central Clinical Hospital “RZD-medicine”, 49 patients (mean age 67.8 ± 7.5 years) with verified prostate cancer diagnosis underwent high dose-rate brachytherapy in the regimen of 2 sessions of 15 Gy with 192Ir source. The inclusion criteria were disease stage ≤сТ2с, Gleason score ≤7. Patients were divided into 2 groups: 1st – patients with incidental prostate cancer (n = 21) who previously (more than 6 months ago, mean time 9.4 ± 2.4 months) underwent transurethral prostatectomy; 2nd – patients with verified prostate cancer (mean prostate volume 56 cm3) and obstructive symptoms without previous transurethral prostatectomy (n = 28).Results. In both groups, no intraoperative complications were observed. In 6 (28 %) patients of the 1st group and 2 patients of the 2nd group, grade II genitourinary toxicity in the form of moderate dysuria and nocturia was observed. Acute gastrointestinal toxicity was observed in 3 (14 %) patients of the 1st group, in the 2nd group such complications were absent. In the 2nd group during the postoperative period after the 2nd session, 4 patients (14 %) experienced acute urinary retention requiring cystostomy.Conclusion. High dose-rate brachytherapy is a safe and effective radical treatment method for patients with localized prostate cancer with obstructive symptoms who have contraindications for surgical treatment.

Introduction. Despite the development of minimally invasive technological methods for the treatment of urolithiasis, improving the functional state of the kidneys in the postoperative period does not

Immune checkpoint inhibitors have revolutionized the treatment of urothelial carcinoma. They are now part of the standard of care for locally advanced or metastatic urothelial carcinoma. Maintenance therapy with avelumab has been found to be the most effective compared to other immune checkpoint inhibitors. To date, platinum-containing chemotherapy followed by maintenance therapy with avelumab is the only regimen that has significantly improved overall survival in patients with advanced bladder cancer. The article presents the experience of maintenance therapy with avelumab on the example of 3 clinical cases of patients with inoperable forms of urothelial carcinoma. The experience of treating 3 patients who achieved stabilization with standard chemotherapy and received maintenance therapy with avelumab was retrospectively analyzed. The age of the patients ranged from 66 to 79 years, the study included two men and one woman. In two cases, muscle-invasive bladder cancer was initially verified, in one – progression 7 years after the start of treatment for non-muscle-invasive bladder cancer. Only in one of the cases, the volumetric formation of the bladder was radically removed, while distant metastases were detected 20 months after the operation, the rest of the patients did not receive radical treatment. The general condition allowed all patients to receive a full course of platinum-containing chemotherapy (gemcitabine + cisplatin or gemcitabine + carboplatin), partial remission was achieved. Maintenance immunotherapy with avelumab was started within a month of completion of chemotherapy. The duration of maintenance therapy currently ranges from 3 to 17 months; stabilization of the oncological process has been achieved in all cases. No clinically significant adverse side effects were noted in any of the cases. Our experience of maintenance immunotherapy with avelumab corresponds to world practice and illustrates the efficacy and safety of this drug.

Testicular torsion refers to diseases of the acute scrotum group and requires early diagnosis and emergency surgical care. Despite the characteristic clinical signs, sometimes there are difficulties in diagnosis, which leads to delayed treatment and irreversible damage to the testicle. The article describes a clinical case of testicular torsion in a young patient with errors in diagnosis, which led to the removal of the testicle. As a result of a diagnostic error – an incorrect collected anamnesis and not timely execution of ultrasound dopplerography, conservative treatment for epididymoorchitis was carried out. The given example illustrates the importance of a thorough study of the anamnesis of the disease – the onset and nature of pain, nausea, as well as local symptoms that are not characteristic of other acute testicular diseases. In addition, if a testicular torsion is suspected, it is necessary to perform urgent, sometimes repeated ultrasound dopplerography of the scrotum organs, which is of irreplaceable value for solving the issue of emergency surgical treatment. At the slightest suspicion of testicular torsion, in particular the presence of several characteristic symptoms and ultrasound data, you need to resort to emergency surgery.

Introduction. In recent years, there has been a persistent trend towards an increase in the incidence of urolithiasis. The treatment of large and complex kidney stones greatest difficulty is one of the challenges. Such stones, as well as surgical methods of their removal, can have an adverse effect on the functional state of the kidneys, which confers a significant medical, social and economic problem. The purpose of this study is to identify factors affecting the functional state of the kidneys in the postoperative period when using various video endoscopic methods of surgical treatment of patients with large and complex kidney stones. Materials and methods. We analyzed the results of treatment of 97 patients with large and complex kidney stones. Depending on the treatment, all these patients were divided into three groups: 1st – 44 (45,36%) patients who underwent percutaneous nephrolithotripsy in prone position, 2nd – 29 (29,9%) patients who underwent percutaneous nephrolithotripsy in the supine position, 3rd – 24 (24,74%) of the patient who underwent pyelolithotomy with laparoscopic and retroperitoneoscopic approaches. Assessment of the area and density of stones was performed by computed tomography. The glomerular filtration rate (GFR) was calculated by CKD-PI formula and dynamic nephroscintigraphy was used to assess of each kidney function. Results. In the postoperative period, the decrease in GFR was most pronounced in the group of patients after percutaneous nephrolithotripsy in the supine position. Among the most significant factors worsening this indicator were the volume of intraoperative (r=0,410, p<0,001, n=97) and postoperative blood loss (r=0,294, p <0.01, n=97), duration of surgery (r=0,187, p <0,1, n=97), density (r=0,426, p <0,001, n=97) and the area (r=0,554, p <0,001, n=97) of the concretion, as well as the body mass index (r=0,294, p <0,01, n=97). Conclusions. The most significant factors that have a negative impact on the functional state of the kidneys were the density and area of the stone, the patient's body mass index and the volume of intraoperative blood loss. The least deterioration of kidney function in the postoperative period was observed with endoscopic pyelolithotomy, and the greatest – with percutaneous nephrolithotripsy in the patient's back position.