Ren'AN Wu

Catalyst design plays a crucial role in numerous chemical processes, significantly impacting efficiency and sustainability.

The HILIC enrichment is a greatly compatible strategy for the extraction of glycopeptides in proteomics. Herein, a boric acid and fructose-1,6-diphosphate (FDP) dual-functionalized Zr-based metal–organic framework material UIO-PBA&FDP (UIO is the abbreviation for the University of Oslo, and PBA is the abbreviation for carboxy phenylboronic acid) was synthesized, characterized with the desirable excellent hydrophilicity and thus was explored for the enrichment of N-linked glycopeptides utilizing the HILIC interaction between the glycopeptides and the hydrophilic UIO-PBA&FDP at a high level of ACN concentration. A total of 359 N-linked glycopeptides corresponding to 104 glycoproteins were identified from only 1 μL of digested human serum by the enrichment of UIO-PBA&FDP, which showed a superiorly high coverage of the identified glycopeptides. The dual hydrophilic functionalized UIO-PBA&FDP could be an efficient HILIC material for the enrichment of N-linked glycopeptides from complex biological samples.

An approach for simultaneous enrichment of N-glycopeptides, mono- and multi-phosphopeptides was developed based on a multi-functional DZMOF-FDP material that provides multiple interactions of HILIC, IMAC, and MOAC.

A solvent-mediated precipitating synthesis was developed to efficiently prepare novel high-purity Cu₁₃H₁₀(SR)₃(PPh₃)₇nanoclusters with an aesthetic crystal structure, unique optical properties and ultrafast relaxation dynamics.

A biligand Zr-MOF (biUIO-66–NH₂NO₂) with alkali-resistance performance and active functional groups has been synthesized, which was further immobilized of Zr⁴⁺ ions as biDZMOF for global phosphopeptides enrichment.

In this study, core-shell mesoporous silica. carbon composite microspheres ( Sil @ MC) were prepared by one-step coating of the phenol formaldehyde polymer ( PF) on SiO2 surface and by carbonizing the PF polymer under nitrogen atmosphere. The morphology observation of the Sil@ MC stationary phase showed that it had good monodispersity. Surface area (302 m(2) / g), mean pore diameter ( 9. 5 nm), and pore volume ( 0. 63 cm(3) / g) of Sil@ MC materials were also measured by pore structure analysis. The results showed that the Sil@ MC was successfully immobilized on the silica particles via copolymerization and carbonization. As a stationary phase of HPLC, the Sil@ MC column was filled by a slurry method. The Sil@ MC materials formed after calcination of SiO2 coated with phenolic resin could be used for the separation of four polar sugar compounds ( D-(+)-glucosamine hydrochloride, glucose, D-(+)-trehalose dihydrat and raffinose) with the mobile phase of acetonitrile.water ( containing 0. 1% ( v / v) formic acid). However, the material formed by calcinating SiO2 without coating phenolic resin could not separate these polar sugar compounds by HPLC-MS. Finally, the representative oligo-saccharide isomers of raffinose, melezitose and stachyose, nystose, and human milk oligosaccharide isomers, such as 3'-sialyllactose, 6'-sialyllactose and lacto-N-newtetraose, lacto-N-te-traose, were successfully separated by the Sil@ MC column with good peak shapes. The results demonstrates that silica. carbon composites derived from phenolic resin have potential application in polar compounds chromatographic separation.

This work reported the synthesis and crystal structure of [PdAu₁₃(PPh₃)₃(SR)₇]⁺ nanocluster. It has a concave polyhedron Au₉Pd kernel, an Au₂(SR)₃ motif, two Au(SR)₂ motifs and three triphenylphosphine, which looks like a girl dancing ballet.

Calixarenes are cyclic oligomers composed of phenol units linked by methylene bridges. Because of their unique host. guest recognition ability, calixarenes are considered to be the main representatives of the third generation of supramolecular chemistry after crown ethers and cyclodextrins. Calixarenes are widely used in ion channel as well as in organic catalytic reactions, transmembrane transport, purification, and chromatographic separation. A variety of versatile calixarene derivatives with different recognition ability and special selectivity were prepared by modifying different types of compounds due to calixarenes are easy to derivatize. These derivatives were successfully applied to different chromatographic modes to achieve the separation and analysis of complex samples. This review summarizes the recent advances in stationary phases based on calixarenes and their derivatives for liquid chromatography The prospects of calixarenes in chromatographic separation science are also presented.