Jingyuan Sun
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Jingyuan Sun has a total of 5 co-authors. Here are the top co-authors by number of shared publications:
- Bang An
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
1 shared publication - Jiru Wu
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
1 shared publication - Nicole Joy de Voogd
Institute of Biology Leiden (IBL), Leiden University, 2300 RA Leiden, The Netherlands
1 shared publication - Wei Cheng
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
1 shared publication - Wenhan Lin
Peking University
1 shared publication
Latest Publications
- Open Access
- 2 January 2018
- Published by MDPI AG in Marine Drugs
- Vol. 16 (1) , 9
Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria
Anti-biofilm assay guided fractionation of the marine sponge Stylissa massa revealed the butanol soluble fraction that was possessing the inhibitory activity toward the biofilm formation of bacterium E. coli. Chromatographic separation of the bioactive fraction resulted in the isolation of 32 bromopyrrole alkaloids, including six new alkaloids, named stylisines A–F (1–6). The structures of new alkaloids were established by comprehensive analyses of the two-dimensional (2D) NMR (COSY, HMQC, and HMBC) and the high resolution electrospray ionization mass spectroscopy (HRESIMS) data, while the absolute configurations were determined by the X-ray diffraction and the electronic circular dichroism (ECD) data. Bioassay results indicated that phakellin-based alkaloids, including dibromoisophakellin and dibromophakellin, significantly reduced the biofilm formation of the bacterium E. coli. Present work provided a group of new natural scaffolds for the inhibitory effects against the biofilm formation of E. coli.
- 2 January 2018
- Published by MDPI AG in Marine Drugs
- Vol. 16 (1) , 9
Open AccessBromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria
Anti-biofilm assay guided fractionation of the marine sponge Stylissa massa revealed the butanol soluble fraction that was possessing the inhibitory activity toward the biofilm formation of bacterium E. coli. Chromatographic separation of the bioactive fraction resulted in the isolation of 32 bromopyrrole alkaloids, including six new alkaloids, named stylisines A–F (1–6). The structures of new alkaloids were established by comprehensive analyses of the two-dimensional (2D) NMR (COSY, HMQC, and HMBC) and the high resolution electrospray ionization mass spectroscopy (HRESIMS) data, while the absolute configurations were determined by the X-ray diffraction and the electronic circular dichroism (ECD) data. Bioassay results indicated that phakellin-based alkaloids, including dibromoisophakellin and dibromophakellin, significantly reduced the biofilm formation of the bacterium E. coli. Present work provided a group of new natural scaffolds for the inhibitory effects against the biofilm formation of E. coli.