Ting-Yen Tsai
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Ting-Yen Tsai has a total of 6 co-authors. Here are the top co-authors by number of shared publications:
- Chau Yee Ng
Department of Dermatology Chang Gung Memorial Hospital Linkou, Taipei, Taoyuan, Keelung Taiwan
1 shared publication - Chih-Hsun Yang
Department of Dermatology, Chang Gung Memorial Hospital, 5 Fusing Street, Kwei-Shan, Tao-Yaun 33302, Taiwan
1 shared publication - Jiann-Der Lee
Department of Electrical Engineering, Chang Gung University, Taoyuan 333, Taiwan
1 shared publication - Meng-Tsan Tsai
Department of Electrical Engineering, Chang Gung University, Taoyuan 33302, Taiwan
1 shared publication - Su-Chin Shen
Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 33305, Taiwan
1 shared publication - Ya-Ju Lee
Program on Key Materials Academy of Innovative Semiconductor and Sustainable Manufacturing (AISSM) National Cheng Kung University No. 1, University Road Tainan City 70101 Taiwan
1 shared publication
Latest Publications
- Open Access
Evaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography
The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was used to observe drug diffusion through an induced MAZ array. Subsequently, nails were treated with cream and liquid topical drugs to investigate the feasibility and diffusion efficacy of laser-assisted drug delivery. Our results show that fractional CO2 laser improves the effectiveness of topical drug delivery in the nail plate and that OCT could potentially be used for in vivo monitoring of the depth of laser penetration as well as real-time observations of drug delivery.
Open AccessEvaluation of Laser-Assisted Trans-Nail Drug Delivery with Optical Coherence Tomography
The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO2 laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser–skin tissue interaction, sparing the patient from an invasive surgical sampling procedure. The time-dependent OCT intensity variance was used to observe drug diffusion through an induced MAZ array. Subsequently, nails were treated with cream and liquid topical drugs to investigate the feasibility and diffusion efficacy of laser-assisted drug delivery. Our results show that fractional CO2 laser improves the effectiveness of topical drug delivery in the nail plate and that OCT could potentially be used for in vivo monitoring of the depth of laser penetration as well as real-time observations of drug delivery.