Liyuan Liu
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Liyuan Liu has a total of 7 co-authors. Here are the top co-authors by number of shared publications:
- Chun-Peng James Chen
School of Animal Sciences, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
1 shared publication - Jia Tian
Animal Husbandry Workstation, Yinchuan 750001, Ningxia, China
1 shared publication - Jinghang Zhou
School of Agriculture, Ningxia University, Yinchuan 750021, Ningxia, China
1 shared publication - Juan Zhang
College of Animal Science and Technology, Ningxia University, Yinchuan, China
1 shared publication - Wan Wen
Animal Husbandry Workstation, Yinchuan 750001, Ningxia, China
1 shared publication - Yaling Gu
College of Animal Science and Technology, Ningxia University, Yinchuan 750021, China
1 shared publication
Latest Publications
- Open Access
GWAS-Based Identification of New Loci for Milk Yield, Fat, and Protein in Holstein Cattle
High-yield and high-quality of milk are the primary goals of dairy production. Understanding the genetic architecture underlying these milk-related traits is beneficial so that genetic variants can be targeted toward the genetic improvement. In this study, we measured five milk production and quality traits in Holstein cattle population from China. These traits included milk yield, fat, and protein. We used the estimated breeding values as dependent variables to conduct the genome-wide association studies (GWAS). Breeding values were estimated through pedigree relationships by using a linear mixed model. Genotyping was carried out on the individuals with phenotypes by using the Illumina BovineSNP150 BeadChip. The association analyses were conducted by using the fixed and random model Circulating Probability Unification (FarmCPU) method. A total of ten single-nucleotide polymorphisms (SNPs) were detected above the genome-wide significant threshold (p < 4.0 × 10−7), including six located in previously reported quantitative traits locus (QTL) regions. We found eight candidate genes within distances of 120 kb upstream or downstream to the associated SNPs. The study not only identified the effect of DGAT1 gene on milk fat and protein, but also discovered novel genetic loci and candidate genes related to milk traits. These novel genetic loci would be an important basis for molecular breeding in dairy cattle.
Open AccessGWAS-Based Identification of New Loci for Milk Yield, Fat, and Protein in Holstein Cattle
High-yield and high-quality of milk are the primary goals of dairy production. Understanding the genetic architecture underlying these milk-related traits is beneficial so that genetic variants can be targeted toward the genetic improvement. In this study, we measured five milk production and quality traits in Holstein cattle population from China. These traits included milk yield, fat, and protein. We used the estimated breeding values as dependent variables to conduct the genome-wide association studies (GWAS). Breeding values were estimated through pedigree relationships by using a linear mixed model. Genotyping was carried out on the individuals with phenotypes by using the Illumina BovineSNP150 BeadChip. The association analyses were conducted by using the fixed and random model Circulating Probability Unification (FarmCPU) method. A total of ten single-nucleotide polymorphisms (SNPs) were detected above the genome-wide significant threshold (p < 4.0 × 10−7), including six located in previously reported quantitative traits locus (QTL) regions. We found eight candidate genes within distances of 120 kb upstream or downstream to the associated SNPs. The study not only identified the effect of DGAT1 gene on milk fat and protein, but also discovered novel genetic loci and candidate genes related to milk traits. These novel genetic loci would be an important basis for molecular breeding in dairy cattle.