Maarisha Upadhyay
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Maarisha Upadhyay has a total of 8 co-authors. Here are the top co-authors by number of shared publications:
- Amrita K. Cheema
Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, USA
1 shared publication - John B. Tyburski
Nelson Scientific Labs, LLC, Potomac, MD 20854, USA
1 shared publication - Kirandeep K. Gill
Department of Comparative Biomedical Sciences, College of Veterinary Medicine Mississippi State University Mississippi State Mississippi USA
1 shared publication - Marjan Boerma
Division of Radiation Health, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
1 shared publication - Meena U. Rajagopal
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA
1 shared publication - Shivani Bansal
Department of Oncology, Lombardi Comprehensive Cancer Centre, Georgetown University Medical Center, Washington, DC 20057, USA
1 shared publication
Latest Publications
- Open Access
- 17 June 2020
- Published by MDPI AG in Metabolites
- Vol. 10 (6) , 252
Identification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (16O) and protons (1H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.
- 17 June 2020
- Published by MDPI AG in Metabolites
- Vol. 10 (6) , 252
Open AccessIdentification of Plasma Lipidome Changes Associated with Low Dose Space-Type Radiation Exposure in a Murine Model
Long-term exposures to low dose space radiation may have adverse effects on human health during missions in deep space. Conventional dosimetry, monitoring of prodromal symptoms, and peripheral lymphocyte counts are of limited value as biomarkers of organ- and tissue-specific radiation injury, particularly of injuries that appear weeks or months after radiation exposure. To assess the feasibility of using plasma metabolic and lipidomic profiles as biomarkers of injury from space radiation, we used a mouse model of exposure to low doses of oxygen ions (16O) and protons (1H). Plasma profiles were compared with those of mice exposed to γ-rays as a reference set. Our results demonstrate major changes in glycerophospholipid metabolism, amino acid metabolism, as well as fatty acid metabolism. We also observed dyslipidemia and lipid peroxidation, suggesting an inflammatory phenotype with possible long-term consequences to overall health upon exposure to low doses of high linear energy transfer (LET) radiation.