Tulin Akarsu Ayazoglu
Research Subjects
Research Interests
Tulin Akarsu Ayazoglu has a total of 42 co-authors. Here are the top co-authors by number of shared publications:
- Abele Donati
Anesthesia and Intensive Care Clinic, Polytechnic University of Marche, Via Tronto 10/a, 60126 Ancona, Italy
1 shared publication - Alejandro Rodríguez
Department of Medicine and Surgery, Rovira Virgili University, 43201 Tarragona, Spain
1 shared publication - Andrius Pranskunas
Department of Intensive Care Medicine, Lithuanian University of Health Sciences, LT-50161 Kaunas, Lithuania
1 shared publication - Anthony Holley
Intensive Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia; The University of Queensland, Saint Lucia, Australia; Jamieson Trauma Institute, Saint Lucia, Australia
1 shared publication - Antônio Tonete Bafi
Instituto Latino-Americano de Sepsis, Sao Paulo, Brazil
1 shared publication - Arjen Mattheus Dondorp
Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
1 shared publication
Latest Publications
- 1 January 2018
- Published by Kare Publishing in Eurasian Journal of Medical Investigation
- Vol. 2 (1) , 12-17
Determination of the risk factors that will play a role in the pressure sore prevalence and the development of pressure sore in patients hospitalized in a chest cardiovascular surgical intensive care unit
Ejmi Eurasian Journal of Medical Investigation
- 1 January 2018
- Published by Kare Publishing in Eurasian Journal of Medical Investigation
- Vol. 2 (1) , 12-17
Determination of the risk factors that will play a role in the pressure sore prevalence and the development of pressure sore in patients hospitalized in a chest cardiovascular surgical intensive care unit
Ejmi Eurasian Journal of Medical Investigation
- Open Access
- 18 October 2017
- Published by Springer Nature in Critical Care
- Vol. 21 (1) , 1-9
Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis
Mildly elevated lactate levels (i.e., 1–2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome. This study was a predefined subanalysis of a multicenter international point prevalence study on microcirculatory flow abnormalities, the Microcirculatory Shock Occurrence in Acutely ill Patients (microSOAP). Microcirculatory flow abnormalities were assessed with sidestream dark-field imaging. Abnormal microcirculatory flow was defined as a microvascular flow index (MFI) < 2.6. MFI is a semiquantitative score ranging from 0 (no flow) to 3 (continuous flow). Associations between microcirculatory flow abnormalities, single-spot lactate measurements, and outcome were analyzed. In 338 of 501 patients, lactate levels were available. For this substudy, all 257 patients with lactate levels ≤ 2 mmol/L (median [IQR] 1.04 [0.80–1.40] mmol/L) were included. Crude ICU mortality increased with each lactate quartile. In a multivariable analysis, a lactate level > 1.5 mmol/L was independently associated with a MFI < 2.6 (OR 2.5, 95% CI 1.1–5.7, P = 0.027). In a heterogeneous ICU population, a single-spot mildly elevated lactate level (even within the reference range) was independently associated with increased mortality and microvascular flow abnormalities. In vivo microscopy of the microcirculation may be helpful in discriminating between flow- and non-flow-related causes of mildly elevated lactate levels. ClinicalTrials.gov, NCT01179243 . Registered on August 3, 2010.
- 18 October 2017
- Published by Springer Nature in Critical Care
- Vol. 21 (1) , 1-9
Open AccessMildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis
Mildly elevated lactate levels (i.e., 1–2 mmol/L) are increasingly recognized as a prognostic finding in critically ill patients. One of several possible underlying mechanisms, microcirculatory dysfunction, can be assessed at the bedside using sublingual direct in vivo microscopy. We aimed to evaluate the association between relative hyperlactatemia, microcirculatory flow, and outcome. This study was a predefined subanalysis of a multicenter international point prevalence study on microcirculatory flow abnormalities, the Microcirculatory Shock Occurrence in Acutely ill Patients (microSOAP). Microcirculatory flow abnormalities were assessed with sidestream dark-field imaging. Abnormal microcirculatory flow was defined as a microvascular flow index (MFI) < 2.6. MFI is a semiquantitative score ranging from 0 (no flow) to 3 (continuous flow). Associations between microcirculatory flow abnormalities, single-spot lactate measurements, and outcome were analyzed. In 338 of 501 patients, lactate levels were available. For this substudy, all 257 patients with lactate levels ≤ 2 mmol/L (median [IQR] 1.04 [0.80–1.40] mmol/L) were included. Crude ICU mortality increased with each lactate quartile. In a multivariable analysis, a lactate level > 1.5 mmol/L was independently associated with a MFI < 2.6 (OR 2.5, 95% CI 1.1–5.7, P = 0.027). In a heterogeneous ICU population, a single-spot mildly elevated lactate level (even within the reference range) was independently associated with increased mortality and microvascular flow abnormalities. In vivo microscopy of the microcirculation may be helpful in discriminating between flow- and non-flow-related causes of mildly elevated lactate levels. ClinicalTrials.gov, NCT01179243 . Registered on August 3, 2010.