Alejandra Esquivel Pineda

Background ARDS due to COVID-19 infection has a unique phenotype generating a growing need to determine the existing differences that can alter existing evidence-based management strategies for ARDS, particularly those related to ventilator management. Research Question: What differences does the clinical profile of patients with ARDS due to COVID 19 and Non-COVID 19 have? Study Design and Methods: We conducted a comparative, observational, retrospective study in the ICU of a third-level hospital in Mexico City, from March 2020 through March 2022. Clinical, echocardiographic, and laboratory variables were compared between patients with ARDS due to SARS-COV2 infection and those due to other etiologies. For qualitative variables, the chi-square test was used. Results We enrolled 140 patients with a diagnosis of ARDS. The study group of COVID-19 etiology were younger males, higher body mass index, progressed to organ dysfunction, required more frequently renal replacement therapy, and higher SOFA score. There was no difference in rates of right ventricular dysfunction. Interpretation: COVID-19 ARDS exhibit much greater severity that led to higher admission and mortality rates, whilst being younger and less comorbid.

Ratio ventilatorio como índice predictor de fracaso al retiro de la ventilación mecánica invasiva en el paciente críticamente enfermo Ventilatory ratio as a predictor index of failure to withdrawal of invasive mechanical ventilation in the critically ill patient Relação ventilatória como índice preditor de falha na retirada de ventilação mecânica invasiva no paciente em estado crítico

COVID-19 represents the greatest health challenge of modern years. The spectrum of illness comprises respiratory and non-respiratory manifestations. We report the case of an adult man with COVID-19 who presented with rhabdomyolysis as a principal extrapulmonary manifestation. Our patient presented with dyspnea, fever, and muscle pain. After a comprehensive approach, the diagnosis of COVID-19 and rhabdomyolysis was made. He developed acute kidney injury requiring renal replacement therapy without reversibility, despite optimal treatment. We performed a literature search for similar cases, discuss the potential mechanisms implied, and propose a diagnostic-therapeutic algorithm.

On January 30th, 2020, the WHO declared the outbreak of COVID19, a disease due to the new coronavirus called SARS-CoV-2. Certain comorbidities, symptoms and signs are characteristic of COVID19 in the general population and in pregnant women. However, pregnant women are considered as a high-risk group for COVID19. To know about the frequency of comorbidities, signs and symptoms, the presence of lymphopenia, antibodies response to SARS-CoV2 and cytokine and chemokine serum concentration, six pregnant women with COVID19 were studied at the moment of admission. The lower concentration of CCL17 was detected in the Pregnant COVID19 group, similar concentration of IL-6 was also detected in non-pregnant and pregnant COVID19 patients. Our result show that pregnant and non-pregnant women with COVID19 has similar cytokine profile.