S. Shaun Murphree
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
S. Shaun Murphree has a total of 9 co-authors. Here are the top co-authors by number of shared publications:
Jeremy D. Mason
4 shared publicationsTheodore G. Bean
Department of Chemistry, Allegheny College, Meadville, Pennsylvania 16335, United States
2 shared publicationsBenjamin R. Eyer
1 shared publicationChad N. Ungarean
1 shared publicationCianán B. Russell
School of Chemistry & Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, United States
1 shared publicationCorey S. Keenan
Department of Chemistry, Allegheny College, Meadville, PA, USA
1 shared publication
Latest Publications
- 28 April 2017
- Published by Taylor & Francis in Synthetic Communications
- Vol. 47 (11) , 1085-1089
Rapid and convenient conversion of nitroarenes to anilines under microwave conditions using nonprecious metals in mildly acidic medium
Nitroarenes are reduced to the corresponding aniline derivatives using iron or zinc under mild conditions under microwave heating conditions. Mild acidity is provided by ammonium chloride in an aqueous methanol medium. The conditions are tolerant to other functional groups, with the exception of bromoalkyl derivatives, which yield complex reaction mixtures; otherwise, yields are generally quite high (80–99%). GRAPHICAL ABSTRACT
- 28 April 2017
- Published by Taylor & Francis in Synthetic Communications
- Vol. 47 (11) , 1085-1089
Rapid and convenient conversion of nitroarenes to anilines under microwave conditions using nonprecious metals in mildly acidic medium
Nitroarenes are reduced to the corresponding aniline derivatives using iron or zinc under mild conditions under microwave heating conditions. Mild acidity is provided by ammonium chloride in an aqueous methanol medium. The conditions are tolerant to other functional groups, with the exception of bromoalkyl derivatives, which yield complex reaction mixtures; otherwise, yields are generally quite high (80–99%). GRAPHICAL ABSTRACT
- 10 February 2017
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 49 (10) , 2177-2181
Total Synthesis of an Antifouling Marine Furanosesquiterpene
An antifouling sesquiterpene isolated from Sinularia sp. was synthesized from citronellyl acetate in eight steps and 9% overall yield. The furan moiety was constructed using a multifunctional sulfone reagent.
- 10 February 2017
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 49 (10) , 2177-2181
Total Synthesis of an Antifouling Marine Furanosesquiterpene
An antifouling sesquiterpene isolated from Sinularia sp. was synthesized from citronellyl acetate in eight steps and 9% overall yield. The furan moiety was constructed using a multifunctional sulfone reagent.
- 17 February 2014
- Published by American Chemical Society (ACS) in Journal of Chemical Education
- Vol. 91 (4) , 511-517
A Student-Centered First-Semester Introductory Organic Laboratory Curriculum Facilitated by Microwave-Assisted Synthesis (MAOS)
- 17 February 2014
- Published by American Chemical Society (ACS) in Journal of Chemical Education
- Vol. 91 (4) , 511-517
A Student-Centered First-Semester Introductory Organic Laboratory Curriculum Facilitated by Microwave-Assisted Synthesis (MAOS)
- 8 May 2013
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 24 (11) , 1391-1394
Microwave-Assisted Aqueous Krapcho Decarboxylation
The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent.
- 8 May 2013
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 24 (11) , 1391-1394
Microwave-Assisted Aqueous Krapcho Decarboxylation
The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. Various salt additives were examined, and both the cation and the anion impacted the facility of the reaction. A strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. Lithium sulfate gave the best results, obviating the need for DMSO co-solvent.
- 26 March 2012
- Published by Taylor & Francis in Synthetic Communications
- Vol. 42 (13) , 1979-1986
Rapid Aqueous Borohydride Reduction of Carbonyls Under Sealed-Tube Microwave Conditions
Ketones and aldehydes are conveniently and rapidly reduced to the corresponding alcohols in good yields using sodium borohydride under sealed-tube microwave conditions in either 95% ethanol or water. In purely aqueous systems, highly aliphatic substrates are sluggish, but this can be overcome by introducing sodium dodecyl sulfate (SDS) at the critical micelle concentration. With a 2:1 substrate/borohydride ratio and a reaction temperature of 100 °C, reduction is typically complete within 1 min in 95% ethanol and 5 min in water/SDS. The methodology is well suited for parallel and combinatorial synthetic approaches.
- 26 March 2012
- Published by Taylor & Francis in Synthetic Communications
- Vol. 42 (13) , 1979-1986
Rapid Aqueous Borohydride Reduction of Carbonyls Under Sealed-Tube Microwave Conditions
Ketones and aldehydes are conveniently and rapidly reduced to the corresponding alcohols in good yields using sodium borohydride under sealed-tube microwave conditions in either 95% ethanol or water. In purely aqueous systems, highly aliphatic substrates are sluggish, but this can be overcome by introducing sodium dodecyl sulfate (SDS) at the critical micelle concentration. With a 2:1 substrate/borohydride ratio and a reaction temperature of 100 °C, reduction is typically complete within 1 min in 95% ethanol and 5 min in water/SDS. The methodology is well suited for parallel and combinatorial synthetic approaches.