Ahmad Abdi

Introduction: The crucial role of adipose tissue (AT) in energy balance has sparked significant interest in researching this tissue as a potential target for obesity treatment. Exercise and dietary interventions are promising strategies for addressing obesity. This study aimed to examine the impact of aerobic training and royal jelly on the ...

This study investigated the eight-week concomitant effects of aerobic training (AT) and curcumin (Cu) supplementation on the oxidant-antioxidant pathway and apoptosis in the hippocampus of cadmium (Cd)-exposed male Wistar rats, specifically focusing on miR-21 and miR-133. Forty male Wistar rats were randomly assigned to five groups (n=8 per group): 1) Control ©, 2) Cadmium (Cd), 3) Cd+Cu, 4) Cd+AT, and 5) Cd+Cu+AT. Groups 2-5 received 5 mg/kg/day of cadmium via drinking water. AT groups engaged in an 8-week aerobic exercise regimen, five sessions per week. Furthermore, groups 3 and 5 received 160 µL/kg/day of curcumin orally. Cd exposure significantly disrupted the oxidant-antioxidant balance (decreased SOD and GPx, increased MDA; all p < 0.001) and elevated the Bax/BCL-2 ratio (p < 0.001). The combination of AT and Cu markedly counteracted these effects; SOD and GPx levels significantly increased, while MDA showed a significant decrease (p < 0.001). Moreover, this combined intervention notably reduced P53 expression and the Bax/BCL-2 ratio (both p < 0.001), demonstrating a robust protective effect against cadmium toxicity. Importantly, regarding microRNAs, the Cd+AT+Cu group exhibited a significant reduction in miR-21 and a significant increase in miR-133 compared to the Cd group (both p < 0.01). Both aerobic training and curcumin alleviated cadmium-induced oxidative stress and apoptosis. Curcumin alone demonstrated a more pronounced effect than aerobic training. However, the combined intervention of aerobic training and curcumin exhibited remarkable synergistic effects, significantly improving antioxidant status and reducing apoptosis compared to individual treatments and cadmium exposure alone.

Background: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of certain cerebral cortex semaphorins in female Wistar rats. Methods: In this experimental study, 40 female rats were placed into five groups: control (C), amphetamine (A), ...

Background: Alzheimer's disease symptoms indicate that increased Aβ leads to central nervous system dysfunction. Exercise reduces Aβ deposition through the AMPK signaling pathway. Additionally, resveratrol (RSV) has neuroprotective effects related to cognitive decline. Objectives: This study investigated the effects of aerobic training and RSV on the AMPK/PGC-1α/SIRT1 pathway in the hippocampus of Alzheimer's rats. Methods: Thirty-five male Wistar rats were divided into five groups: Normal (NO), Alzheimer's (AD), Alzheimer's-training (ADT), Alzheimer's-resveratrol (ADRSV), and Alzheimer's-training-resveratrol (ADTRSV). The supplement groups received 20 mg of RSV (per kg of body weight) orally during the intervention period. The aerobic exercise program, which included running on a treadmill at speeds of 6 - 18 meters per minute, was performed 5 days a week for eight weeks. Results: Alzheimer's induction caused a significant decrease in the expression of AMPK/PGC-1α/SIRT1 (P = 0.0001). Exercise and RSV significantly increased the expression of AMPK/PGC-1α/SIRT1 in AD rats (P < 0.05). Additionally, significant increases in the expression of AMPK, PGC-1α, and SIRT1 were observed in the ADTRSV group compared to the ADT group (P = 0.034, P = 0.020, and P = 0.038, respectively) and ADRSV (P = 0.026, P = 0.021, and P = 0.021). Conclusions: AD induction was associated with decreased AMPK/PGC-1α/SIRT1 expression. Aerobic exercise and RSV consumption can reverse this decrease. Given the crucial role of this signaling pathway in hippocampal function, alterations in these indicators following physical activity and RSV use may partially mitigate Alzheimer's disease complications.

Introduction: Ferroptosis is a type of iron-dependent cell death that has been identified in the brains of patients with Alzheimer's disease (AD). Exercise and resveratrol (RSV) can delay neurodegenerative diseases, especially AD. The present study aimed to investigate the effect of aerobic training and RSV on hippocampal ferroptosis in a rat model ...

Background & aim: Non-alcoholic fatty liver disease(NAFLD) is an important cause of chronic liver disease worldwide. Mitochondrial dysfunction has been proven to be closely associated with NAFLD. The aim of the present study is to investigate the effect of interval training and omega-3 on mitochondrial biogenesis in liver tissues of ...

زمینه و هدف: در حال حاضر شواهد فزاینده‌ای وجود دارد که نشان می‌دهد مسیرهای پیش‌التهابی که توسط سلول‌های T (که IL-17 و IL-22 را ترشح می‌کنند)، تعدیل می‌شوند، نقش مهمی در کنترل سوخت‌وسازی دارند. هدف از پژوهش حاضر بررسی اثر تمرین هوازی همراه با مصرف عصارة آبی سیر بر بیان IL-17، IL-22 و مقاومت‌ به ‌انسولین موش‌های صحرایی دیابتی با استرپتوزوتوسین است.مواد و روش‌ها: در این تحقیق تجربی،40 سر موش صحرایی نر (سن 5 هفته و وزن 24/15 ± 12/162 گرم) از نژاد ویستار از انستیتو پاستور تهیه و به آزمایشگاه منتقل شدند. پس از انتقال رت‌ها به آزمایشگاه، القای دیابت و آشنایی با فعالیت ورزشی روی نوار گردان ویژة جوندگان، به‌طور تصادفی به پنج گروه کنترل-سالم (CN)، دیابت (DM)، دیابت-تمرین (TDM)، دیابت-سیر (GDM) و دیابت-تمرین-سیر (TGDM) تقسیم شدند. القای دیابت با تزریق داخل‌صفاقی استرپتوزوتوسین به‌صورت تک‌دوز (mg/kg 60) انجام گرفت. قند خون 250 میلی‌گرم بر دسی‌لیتر، حاکی از دیابتی شدن موش‌ها بود. گروه‌های تمرین به مدت هشت هفته برنامة تمرین هوازی (10-18 متر در دقیقه، 10-40 دقیقه در روز، پنج روز در هفته) را روی نوار گردان انجام دادند. روزانه به ازای هر صد گرم وزن موش‌های صحرایی، یک میلی‌لیتر (حدود 4/0 گرم در هر 100 گرم وزن بدن) عصارة...

Background: The present study aimed to compare the effects of three therapeutic methods, including regular aerobic training, hyaluronic acid (HA), and mesenchymal stem cells, on Wnt/β-catenin signaling of cardiac tissue in rats with the experimental model of knee osteoarthritis. Methods: Sixty-three male rats were divided into nine groups (seven in each group): (1) healthy control, (2) patient control, (3) sham, (4) saline, (5) exercise (EXT), (6) mesenchymal stem cells (MSCs), (7) hyaluronic acid, (8) EXT + MSCs, and (9) EXT + HA. After inducing the osteoarthritis (OA) model, we conducted 5 days of running on the treadmill for five weeks for the EXT group. Also, HA was injected intra-articularly. After 12 to 14 hours of fasting and 72 hours following the last training session, we conducted cardiac tissue sampling for β-catenin, GSK-3β, Wnt, Fz, TCF, and DKK1 analysis. We used RT-PCR to analyze the expression of the β-catenin, GSK-3β, Wnt, Fz, TCF, and DKK1 genes in cardiac tissue. The data were analyzed using one-way ANOVA and Tukey's post hoc test (P < 0.05). Results: Osteoarthritis induction significantly decreased the expression of the GSK-3β and DKK1 genes but significantly increased the expression of the β-catenin, Wnt, Fz, and TCF genes of cardiac tissue compared to the control group. However, the EXT, HA, MSC, and combination methods increased the expression of the GSK-3β and DKK1 genes but decreased the expression of the β-catenin, Wnt, Fz, and TCF genes of cardiac tissue, which were significant in the combination group. Conclusions: Regular exercise, along with HA and MSCs, may have protective effects for the following reasons: (1) reducing the expression of the β-catenin, Wnt, Fz, and TCF genes; (2) increasing the expression of the GSK-3β and DKK1 genes in cardiac tissue; and (3) inhibiting Wnt signaling in the heart.