Qian Guo

The trade-off between the potentially detrimental effects of fine particulate matter (PM_2.5) and the benefits of physical activity (PA) is unclear. We aimed to explore the independent and interaction effects between long-term PM_2.5 exposure and PA on blood pressure (BP) and hypertension. A total of 8704 adults (≥45 years) without hypertension at baseline in a nationwide cohort of the China Health and Retirement Longitudinal Study (CHARLS) were followed from 2011 to 2015. The participants were selected using a four-stage, stratified, and cluster sampling procedure. The annual PM_2.5 concentrations at the residential address were estimated from a two-stage machine learning model with a 10 km × 10 km resolution. A standard questionnaire collected information on PA and potential confounders, and metabolic equivalents (MET·h/wk), which combined frequency, intensity, and duration information, were used to assess PA levels. We adopted mixed-effects regression models to explore the independent and interaction effects between long-term PM_2.5 exposure and PA on BP and risk of hypertension. Systolic blood pressure (SBP) decreased by −0.84 mmHg (95% CI: −1.34, −0.34) per an IQR (interquartile range, 175.5 MET·h/wk) increase in PA, and diastolic blood pressure (DBP) decreased by −0.42 mmHg (95% CI: −0.76, −0.07). Each IQR (36.1 μg/m³) increment in PM_2.5 was associated with 0.48 mmHg (95% CI: −0.24, 1.20) in SBP and −0.02 mmHg (95% CI: −0.44, 0.39) in DBP. PM_2.5 showed an elevated effect with risks of hypertension (odds ratio, OR = 1.01; 95% CI: 1.00, 1.03), while PA showed the inverse result (OR = 0.98; 95% CI: 0.97, 0.99). Interaction analyses indicated PA maintained the beneficial effects on BP, but the negative association was attenuated, accompanied by the increase of PM_2.5. PA decreased the BP and hypertension risks, while PM_2.5 showed the opposite results. PM_2.5 attenuated the beneficial effects of PA on BP and modified the association between PA and the risk of hypertension.

Children’s lung function is a significant predictor of health status throughout their lifetime. This study aims to identify the prevalence of impaired lung function in children and the potential influencing factors in elementary school children of Wuhan, China. Children of 6–12 years old were enrolled from elementary schools in Wuhan, China, in 2018, on the basis of a cross-sectional study design. Information on personal behavior patterns and household characteristics, as well as parental factors, was collected based on a questionnaire survey. Spirometry was used to measure fifteen lung function indicators. Logistic regression models were used to estimate odds ratios of prevalence of impaired lung function with regard to socioeconomic, personal behavior patterns, household, and parental factors, respectively. Four lung function indicators such as FET and EVC in urban children had higher values than in the suburban children after adjusting for confounders (p < 0.05). A higher prevalence of impaired lung function (FEV₆, FEV₃, EVC, and VC) was found in the children from the rural area than in those from the urban area. A sex difference in FET impairment was observed, however, no significant difference in impairment in other lung function indicators were found between girls and boys. The elevated height and weight of the children was significantly associated with an increased and decreased prevalence of impaired lung function, respectively, particularly both for FEV₆, FEV₃, FIVC, and FIV₁. Opening windows for a longer time in summer was significantly associated with a lower prevalence of impaired FEF₂₅ and MVV, and an extended time of opening windows in winter was significantly associated with a lower prevalence of impaired FEV₆. While, opening windows for a longer time in autumn was significantly associated with higher prevalence of impaired FEV₆ and FEV₁/VC. Home renovations, doing physical exercise for more than 30 min per day, air pollution exposure during commuting, sleeping in own rooms, height stunting, and preterm birth were significantly associated with an increased risk of impaired lung function. Breastfeeding, having a father with a white-collar profession and with a higher education level were positively associated with the lower prevalence of impaired lung function. Impaired lung function is commonly found in school children in Wuhan, nowadays. Breastfeeding, opening windows long-term in summer and winter, higher socioeconomics, and an urban living environment were protective factors for impaired lung function. However, opening windows long-term and using air conditioning short-term in autumn, as well as home renovations, doing physical exercise for more than 30 min per day, preterm birth, height stunting, and air pollution exposure during commuting were regarded as significant risk factors for impaired lung function. Promoting breastfeeding, lengthening window opening times in winter and summer, and controlling household renovation and air pollution exposure during commuting are recommended to reduce the risk of impaired lung function in children in Wuhan.

Studies on the association of PM_2.5 and its compositions with metabolic syndrome (MetS) were limited, and it was unclear which was the most hazardous composition. In this study, we aimed to investigate the association between PM_2.5 and its compositions with MetS and identified the most hazardous composition. In this study, we included 13,418 adults over 45 years across 446 communities from 150 counties of 28 provinces in nationwide China in 2015. MetS was defined based on the five indicators of the Joint Interim Societies, including: blood pressure (SBP (systolic blood pressure) and DBP (diastolic blood pressure)); fasting blood glucose (FBG); fasting triglyceride (FTG); high density lipoprotein cholesterol (HDL-C); and waist circumference (WC). We used chemical transport models to estimate the concentration of PM_2.5 and its compositions, including black carbon, ammonium, nitrate, organic matter, and sulfate. We used a generalized linear regression model to examine the association of PM_2.5 and its compositions with MetS. In this study, we observed that the average age was 61.40 (standard deviation (SD): 9.59). Each IQR (29.76 μg/m³) increase in PM_2.5 was associated with a 1.27 (95% CI: 1.17, 1.37) increase in the odds for MetS. We indicated that black carbon showed stronger associations than other compositions. The higher associations were observed among women, participants aged less than 60 years, who lived in urban areas and in the Northeast, smokers, drinkers, and the obese populations. In conclusion, our findings identified the most harmful composition and sensitive populations and regions that required attention, which would be helpful for policymakers.

(1) Background: Field monitoring data for addressing the disproportional burden of exposure to soil contamination in communities of minority and low socioeconomic status (SES) are sparse. This study aims to examine the association between soil heavy metal levels, SES, and racial composition. (2) Methods: A total of 423 soil samples were collected in the urban areas of eight cities across six Southern states in the U.S., in 2015. Samples were analyzed using inductively coupled plasma–mass spectrometry (ICP–MS) for eight heavy metals. The association was examined with mixed models with the log-transformed metal concentrations as the dependent variables and rankings of low-income or minority percentages as the explanatory variables. (3) Results: Model results showed that soil metal concentrations were significantly associated with rankings of poverty and minority percentages. The cadmium concentration significantly increased by 4.7% (p-value < 0.01), for every 10 percentiles of increase in poverty rank. For every 10 percentiles of increase in minority rank, the soil concentrations were significantly up (p-values < 0.01) for arsenic (13.5%), cadmium (5.5%), and lead (10.6%). Minority rank had significant direct effects on both arsenic and lead. (4) Conclusions: The findings confirmed elevated heavy metal contamination in urban soil in low-income and/or predominantly minority communities.

Polycyclic aromatic hydrocarbon (PAH) emissions from the combustion of household solid coal for cooking and heating cause great harm to public health in China, especially in less developed areas. Children are one of the most susceptible population groups at risk of indoor air pollutants due to their immature respiratory and immune systems. However, information on PAH exposure of children is limited due to limited monitoring data. In this study, we aimed to assess the seasonal differences of PAHs in classrooms, analyze the pollutant sources, and calculate the incremental lifetime cancer risk attributable to PAHs in Shanxi Provence. A typical school using household coal combustion in Shanxi Province was selected. Fine particulate matter (PM_2.5)samples were collected by both individual samplers and fixed middle-flow samplers during the heating and non-heating seasons in December 2018 and April 2019. The PAH concentrations in PM_2.5 samples were analyzed by a gas chromatograph coupled to a mass spectrometer. The results showed that PAH concentrations in PM_2.5 varied between 89.1 ng/m³ in the heating season and 1.75 ng/m³ in the non-heating season. The mean concentrations of benzo[a]pyrene (BaP), a carcinogenic marker of PAHs, were 10.3 and 0.05 ng/m³ in the heating and non-heating seasons, respectively. Source allocation analysis of individual portable and passive samplers revealed that the main contributors during heating and non-heating seasons were coal combustion and gasoline sources, respectively. According to the results of a Monte Carlo simulation, the incremental lifetime cancer risk values from the inhalation of PAHs in the heating and non-heating seasons were 3.1 × 10⁻⁶ and 5.7 × 10⁻⁸, respectively. The significant increase in PAHs and the incremental lifetime cancer risk in the heating season indicates that children are more exposed to health threats in winter. Further PAH exposure control strategies, including reducing coal usage and promoting clean fuel applications, need to be developed to reduce the risk of PAH-induced cancer.