Saiful Islam
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Research Interests
Saiful Islam has a total of 19 co-authors. Here are the top co-authors by number of shared publications:
- Benjy Jek Yang Tan
Kumamoto University
1 shared publication - Hiroaki Mitsuya
Department of Refractory Viral Diseases, National Center for Global Health and Medicine, Shinjuku, Tokyo 162-8655, Japan
1 shared publication - Hiroo Katsuya
Kumamoto University
1 shared publication - Hiroyuki Gatanaga
AIDS Clinical Center, NCGM, Tokyo, Japan
1 shared publication - Kazuhisa Yoshimura
AIDS Research Center, National Institute of Infectious Diseases Tokyo, Japan
1 shared publication - Kenji Maeda
Division of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University, Kagoshima, 890-8544, Japan
1 shared publication
Latest Publications
- Open Access
- 14 November 2019
- Published by Cold Spring Harbor Laboratory in bioRxiv
- p. 842419
A widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro
Persistence of HIV-1 latent reservoir cells during antiretroviral therapy is a major obstacle for curing HIV-1. Latency-reversing agents (LRAs) are under development to reactivate and eradicate latently infected cells; however, there are few useful models for evaluating LRA activity in vitro. Here, we established a long-term cell culture system harboring thousands of different HIV-1-infected cell clones with a wide distribution of HIV-1 provirus similar to that observed in vivo. A combination of an LRA and antiretroviral therapy (ART) significantly reduced viral rebound upon treatment interruption. Experimental investigation and mathematical modeling demonstrated that addition of LRA to ART induced latency-reversing effect and contributed to the eradication of replication competent HIV-1. The widely distributed intact provirus elimination (WIPE) assay will be useful for optimizing therapeutics against HIV-1 latency and investigating mechanistic insights into the clonal selection of heterogeneous HIV-1-infected cells.
- 14 November 2019
- Published by Cold Spring Harbor Laboratory in bioRxiv
- p. 842419
Open AccessA widely-distributed HIV-1 provirus elimination assay to evaluate latency-reversing agents in vitro
Persistence of HIV-1 latent reservoir cells during antiretroviral therapy is a major obstacle for curing HIV-1. Latency-reversing agents (LRAs) are under development to reactivate and eradicate latently infected cells; however, there are few useful models for evaluating LRA activity in vitro. Here, we established a long-term cell culture system harboring thousands of different HIV-1-infected cell clones with a wide distribution of HIV-1 provirus similar to that observed in vivo. A combination of an LRA and antiretroviral therapy (ART) significantly reduced viral rebound upon treatment interruption. Experimental investigation and mathematical modeling demonstrated that addition of LRA to ART induced latency-reversing effect and contributed to the eradication of replication competent HIV-1. The widely distributed intact provirus elimination (WIPE) assay will be useful for optimizing therapeutics against HIV-1 latency and investigating mechanistic insights into the clonal selection of heterogeneous HIV-1-infected cells.