YWYan Wang
Yan Wang
*This is an algorithmically generated author record based on publicly available information.
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Research Subjects
Yan Wang has a total of 3 co-authors. Here are the top co-authors by number of shared publications:
- Fred Brauer
Department of Mathematics, University of British Columbia, Vancouver, BC V6T 1Z2, Canada
1 shared publication - Jane M. Heffernan
Department of Mathematics and Statistics, York University, Toronto, Ontario, Canada
1 shared publication - Yicang Zhou
Department of Applied Mathematics, Xi’an Jiaotong University, Xi’an, China
1 shared publication
Latest Publications
- 29 August 2012
- Published by Springer Nature in Journal of Mathematical Biology
- Vol. 67 (4) , 901-934
Viral dynamics model with CTL immune response incorporating antiretroviral therapy
We present two HIV models that include the CTL immune response, antiretroviral therapy and a full logistic growth term for uninfected \(\text{ CD4}^+\) T-cells. The difference between the two models lies in the inclusion or omission of a loss term in the free virus equation. We obtain critical conditions for the existence of one, two or three steady states, and analyze the stability of these steady states. Through numerical simulation we find substantial differences in the reproduction numbers and the behaviour at the infected steady state between the two models, for certain parameter sets. We explore the effect of varying the combination drug efficacy on model behaviour, and the possibility of reconstituting the CTL immune response through antiretroviral therapy. Furthermore, we employ Latin hypercube sampling to investigate the existence of multiple infected equilibria.- 29 August 2012
- Published by Springer Nature in Journal of Mathematical Biology
- Vol. 67 (4) , 901-934
Viral dynamics model with CTL immune response incorporating antiretroviral therapy
We present two HIV models that include the CTL immune response, antiretroviral therapy and a full logistic growth term for uninfected \(\text{ CD4}^+\) T-cells. The difference between the two models lies in the inclusion or omission of a loss term in the free virus equation. We obtain critical conditions for the existence of one, two or three steady states, and analyze the stability of these steady states. Through numerical simulation we find substantial differences in the reproduction numbers and the behaviour at the infected steady state between the two models, for certain parameter sets. We explore the effect of varying the combination drug efficacy on model behaviour, and the possibility of reconstituting the CTL immune response through antiretroviral therapy. Furthermore, we employ Latin hypercube sampling to investigate the existence of multiple infected equilibria.