Anthony Costello

Introduction Every year 530 000 women die from maternal causes, four million infants die in the neonatal period, and a similar number are stillborn.w1 w2 Despite a plethora of newly validated interventions, the millennium development goals to reduce maternal mortality by three quarters and child mortality by two thirds are unlikely to be achieved.1 One of the reasons for this is that current safer motherhood and newborn care programmes emphasise interventions that do not reach the poorest households. Community based interventions have been neglected and undervalued. In this article, we argue that large scale community effectiveness trials are both necessary and feasible if we are to make further progress with reducing maternal and child mortality. Peer education is the best method of changing behaviour Footnotes References w1-w13 are on bmj.com Contributors and sources For six years AC, DO, and DM have worked together on a community effectiveness trial to improve maternal and newborn care in rural Nepal. DM has been a national adviser to the government of Nepal on safer motherhood and newborn health policy. AC and DO are collaborating with local partners on perinatal community effectiveness trials in Bangladesh, India, and Malawi. AC will act as guarantor. Competing interest None declared.

More than 9 million neonatal deaths occur each year, 98% of them in developing countries. Neonatal deaths account for two-thirds of deaths in infancy and 40% of deaths before age 5 y. The major direct causes of neonatal death are infections, preterm delivery and asphyxia. Important indirect causes include low birth weight and hypothermia. The present body of work on multiple micronutrient interventions is not sufficient for us to draw conclusions on their effects on neonatal well-being. Because studies have generally concentrated on single micronutrients and a range of outcomes, this paper reviews the findings for individual nutrients and then summarizes the situation. The evidence for the contribution of micronutrient deficiencies to perinatal mortality and duration of gestation is limited, and the evidence base for individual micronutrient effects on neonatal mortality and morbidity is patchy. To translate knowledge into policy, community evaluations of effect and an expanded evidence base that includes affordability, acceptability and scalability are also required. A balance between supply-side and demand-side interventions must be struck, with an emphasis on effect and sustainability. Among the key requirements are randomized, controlled community effectiveness trials of the effect of micronutrient supplementation in pregnancy on perinatal mortality and neurodevelopment, studies on improving adherence and studies on the relation between micronutrient deficiencies and sepsis and neonatal encephalopathy. It would also be helpful to look at mechanisms for bringing the periconceptional period within the ambit of trials.

Objective: To determine home based newborn care practices in rural Nepal in order to inform strategies to improve neonatal outcome. Design: Cross sectional, retrospective study using structured interviews. Setting: Makwanpur district, Nepal. Participants: 5411 married women aged 15 to 49 years who had given birth to a live baby in the past year. Main outcome measures: Attendance at delivery, hygiene, thermal care, and early feeding practices. Results: 4893 (90%) women gave birth at home. Attendance at delivery by skilled government health workers was low (334, 6%), as was attendance by traditional birth attendants (267, 5%). Only 461 (8%) women had used a clean home delivery kit, and about half of attendants had washed their hands. Only 3482 (64%) newborn infants had been wrapped within half an hour of birth, and 4992 (92%) had been bathed within the first hour. 99% (5362) of babies were breast fed, 91% (4939) within six hours of birth. Practices with respect to colostrum and prelacteals were not a cause for anxiety. Conclusions: Health promotion interventions most likely to improve newborn health in this setting include increasing attendance at delivery by skilled service providers, improving information for families about basic perinatal care, promotion of clean delivery practices, early cord cutting and wrapping of the baby, and avoidance of early bathing. What is already known on this topic: Most births in rural south Asia occur at home Neonatal mortality has remained fairly constant in developing countries despite falling infant mortality What this paper adds: Only 6% of births in rural Nepal took place in the presence of a skilled attendant Cord cutting implements were often unclean and drying and wrapping of newborn infants was usually delayed 99% of babies were breast fed, 92% of them within six hours of birth, and colostrum was generally given Interventions need to focus on educating women about hygiene, encouraging early wrapping, and delaying bathing of newborn babies