Soren T. Hoff
Current Organizations / Institutes
The organizations/institutes from the scholar's latest article
Soren T. Hoff has a total of 22 co-authors. Here are the top co-authors by number of shared publications:
- Peter Andersen
Department of Infectious Disease Immunology, Statens Serum Institut, Denmark
3 shared publications - Ahmed M. Salman
Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK
1 shared publication Christian Søborg
Department of Infectious Diseases , Rigshospitalet, Copenhagen, Denmark
1 shared publication- David J. M. Lewis
Surrey Clinical Research Centre, University of Surrey, Guildford, United Kingdom
1 shared publication Denise S. Rodriques
Clemente Ferreira Institute, Federal University of Sao Paulo , Sao Paulo, Brazil 7 Federal University of Sao Paulo , Sao Paulo, Brazil
1 shared publication- Else Marie Agger
Department of Infectious Disease Immunology, Statens Serum Institut, Copenhagen, Denmark
1 shared publication
Latest Publications
- 1 January 2015
- Published by Elsevier in Tuberculosis
- Vol. 95 (1) , 40-47
Human B cells produce chemokine CXCL10 in the presence of Mycobacterium tuberculosis specific T cells
- 1 January 2015
- Published by Elsevier in Tuberculosis
- Vol. 95 (1) , 40-47
Human B cells produce chemokine CXCL10 in the presence of Mycobacterium tuberculosis specific T cells
- Open Access
- 14 May 2013
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (5) , e64215
Randomised Clinical Trial Investigating the Specificity of a Novel Skin Test (C-Tb) for Diagnosis of M. tuberculosis Infection
Tuberculin skin testing is simple and relatively inexpensive, but the specificity of PPD is affected by BCG vaccination. Determine optimal dose and specificity of recombinant ESAT-6 and CFP-10 (C-Tb) produced in Lactococcus lactis for diagnosis of M. tuberculosis infection. In a dose finding phase I trial 0.01 or 0.1 µg preserved and unpreserved C-Tb was injected by Mantoux technique in 38 patients with active tuberculosis and induration responses measured. In a phase II specificity trial in 151 uninfected, BCG vaccinated participants 0.1 µg C-Tb was compared to 2 TU PPD. 0.1 µg C-Tb gave a median induration of 15 mm after 2 days. Phenol preservation did not affect the response. The specificity of C-Tb was 99.3% (95% CI 96–100%) regarding indurations ≥5 mm as a positive outcome. This was higher than the specificity of PPD (63% using a cut-off of 5 mm or 92% using a cut-off of 15 mm to adjust for non-specific BCG responses). Local adverse reactions following C-Tb injection included transient itching and discomfort as expected components of the immune response. C-Tb offers a simple and convenient skin test to diagnose M. tuberculosis infection using a single, universal cut-off unaffected by BCG vaccination. ClinicalTrials.gov NCT01033929 and NCT01241188.
- 14 May 2013
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 8 (5) , e64215
Open AccessRandomised Clinical Trial Investigating the Specificity of a Novel Skin Test (C-Tb) for Diagnosis of M. tuberculosis Infection
Tuberculin skin testing is simple and relatively inexpensive, but the specificity of PPD is affected by BCG vaccination. Determine optimal dose and specificity of recombinant ESAT-6 and CFP-10 (C-Tb) produced in Lactococcus lactis for diagnosis of M. tuberculosis infection. In a dose finding phase I trial 0.01 or 0.1 µg preserved and unpreserved C-Tb was injected by Mantoux technique in 38 patients with active tuberculosis and induration responses measured. In a phase II specificity trial in 151 uninfected, BCG vaccinated participants 0.1 µg C-Tb was compared to 2 TU PPD. 0.1 µg C-Tb gave a median induration of 15 mm after 2 days. Phenol preservation did not affect the response. The specificity of C-Tb was 99.3% (95% CI 96–100%) regarding indurations ≥5 mm as a positive outcome. This was higher than the specificity of PPD (63% using a cut-off of 5 mm or 92% using a cut-off of 15 mm to adjust for non-specific BCG responses). Local adverse reactions following C-Tb injection included transient itching and discomfort as expected components of the immune response. C-Tb offers a simple and convenient skin test to diagnose M. tuberculosis infection using a single, universal cut-off unaffected by BCG vaccination. ClinicalTrials.gov NCT01033929 and NCT01241188.
- Open Access
- 1 September 2007
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 45 (5) , 575-582
Evaluation of Mycobacterium tuberculosis-Specific Antibody Responses in Populations with Different Levels of Exposure from Tanzania, Ethiopia, Brazil, and Denmark
Background. New, simple, and better-performing diagnostic tools are needed for the diagnosis of tuberculosis (TB). Much effort has been invested in d
- 1 September 2007
- Published by Oxford University Press (OUP) in Clinical Infectious Diseases
- Vol. 45 (5) , 575-582
Open AccessEvaluation of Mycobacterium tuberculosis-Specific Antibody Responses in Populations with Different Levels of Exposure from Tanzania, Ethiopia, Brazil, and Denmark
Background. New, simple, and better-performing diagnostic tools are needed for the diagnosis of tuberculosis (TB). Much effort has been invested in d