Kadir Aksu

Cellulose was extracted from waste generated by pruning tea stem wastes. The interaction between pure cellulose and homophthalic acid produced a light (0.22 g·cm^-3) and eco-friendly hybrid aerogel product that is highly absorbent (85 g of water per 1 g of aerogel). The product has a Brunauer-Emmett-Teller surface area of 221 m²·g^-1. In addition, the product was analyzed for its structural and functional properties using scanning electron microscopy, Fourier transform infrared, and X-ray diffraction. The methodology employed in this study is uncomplicated, utilizing easily accessible and sustainable biowaste at a low cost. As a result, the current process is well-adapted for industrial-scale production, with the potential for significant advancements in the field of green materials.

Benzoik asit, metil benzoat bileşikleri ve bunların türevleri oldukça geniş bir alanda aktivite gösteren, sentezi organik kimyacılar için önemli olan kıymetli bileşiklerdir. Bu çalışmada 3,4- dimetoksisinamik asitten başlanarak bir seri reaksiyon sonucunda benzoik asitin metil ester türevi olan metil-4,5-dimetoksi-2-(2-(4-metoksifenil)-2-oksoetil)benzoat’ın sentezi etkin bir şekilde gerçekleştirildi. Sentezlenen bileşiğin yapısı 1H NMR ve 13C NMR spektrumları ile karakterize edildi.

The regio‐ and stereospecific synthesis of O‐methyl‐chiro‐inositols and O‐methyl‐scyllo‐inositol was achieved, starting from p‐benzoquinone. After preparing dimethoxy conduritol‐B as a key compound, regiospecific bromination of the alkene moiety of dimethoxy conduritol‐B and acid‐catalyzed ring opening of dimethoxydiacetate conduritol‐B epoxide with Ac₂O afforded the desired new chiro‐inositol derivatives and scyllo‐inositol derivative, respectively. Spectroscopic methods were employed for the characterization of all synthesized compounds. The novel inositols (11–17) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). The novel inositols 11–17 were found to be effective inhibitors against AChE, hCA I, and hCA II enzymes. K_i values were calculated in the range of 87.59 ± 7.011 to 237.95 ± 17.75 μM for hCA I, 65.08 ± 12.39 to 538.98 ± 61.26 μM for hCA II, and 193.28 ± 43.13 to 765.08 ± 209.77 μM for AChE, respectively. Also, due to the inhibitory effects of the novel inositols 11–17 against the tested enzymes, these novel inositols are potential drug candidates to treat some diseases such as glaucoma, epilepsy, leukemia, and Alzheimer's disease.

In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Initially, some crotonitriles were prepared by condensation of malononitrile with arylmethylketones, which was followed by conversion of them to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by cyclization of the bromocrotonitriles of (R)-1-phenylethylamine applying Gewald method.rnrn rnrn