Xu Wang

An I₂/cumene hydroperoxide (CHP)‐mediated tandem cyclization of 2‐aminoaryl ketone oximes with isocyanides has been developed. Various 2‐aminoquinazolines were obtained in 49–96% yields under transition‐metal‐free conditions, and the resulting 4‐phenylquinazolin‐2‐amines show typical fluorescent emission properties. The key to the success of this strategy involves the formation of iminyl radical via the N−O bond cleavage of hydroxy oxime.

An approach for the synthesis of quinoxaline‐2,3‐diamines is reported using a palladium‐catalyzed cyclization reaction of o‐phenylenediamines and isocyanides. Various quinoxaline‐2,3‐diamines could be obtained in 25%–95% yields at 100 °C for 3 h. The key to the success of this protocol involves the formation of two C−N and one C−C bonds via the double insertion of isocyanide.

A Pd-catalyzed cyclization reaction of 2-(2-vinylarene)acetonitrilesand isocyanides has been documented. Various naphthalen-2-amines wereobtained in moderate to good yields under mild conditions. The invitro cytotoxicity of all products was evaluated by MTT assay againstseven human cancer cell lines. The results indicated that compounds 3ea, 3ma, and 3ob exhibited effectiveanticancer activities against the tested cancer cells.

A palladium‐catalyzed tandem cyclization of 2‐(2‐ethynylphenyl)acetonitriles with isocyanides has been developed. Various indeno[2,1‐b]pyrroles were prepared in 55%–82% yields under air atmosphere at 100 °C. The key to the success of this protocol is construction of new C−C and C−N bonds via the orderly insertion of isocyanides. magnified image

A palladium‐catalysed tandem cyclisation reaction of amidoximes, isocyanides and amines to produce 5‐aminoimidazoles was developed. Various 5‐aminoimidazoles were prepared in good to excellent yields under mild conditions. This elegant domino process involves the effective cleavage of the N−O bond and the formation of new C−C and C−N bonds in a single operation. magnified image